FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004487946> ?p ?o ?g. }

• W2004487946 endingPage "15" @default.
• W2004487946 startingPage "5" @default.
• W2004487946 abstract "DNA damage triggers Atm- and/or Atr-dependent signaling pathways to control cell cycle progression, apoptosis, and DNA repair. However, how Atm and Atr are activated is not fully understood. One of the downstream targets of Atm is non-receptor tyrosine kinase c-Abl, which is phosphorylated and activated by Atm. The current view is that c-Abl relays pro-apoptotic signals from Atm to p73 and p53. Here we show that c-Abl deficiency resulted in a broad spectrum of defects in cell response to genotoxic stress, including activation of Chk1 and Chk2, activation of p53, nuclear foci formation, apoptosis, and DNA repair, suggesting that c-Abl might also act upstream of the DNA damage-activated signaling cascades in addition to its role in p73 and p53 regulation. Indeed, we found that c-Abl is required for proper activation of both Atm and Atr. c-Abl is bound to the chromatin and shows enhanced interaction with Atm and Atr in response to DNA damage. c-Abl can phosphorylate Atr on Y291 and Y310 and this phosphorylation appears to have a positive role in Atr activation under genotoxic stress. These findings suggest that Atm-mediated c-Abl activation in cell response to double-stranded DNA breaks might facilitate the activation of both Atm and Atr to regulate their downstream cellular events." @default.
• W2004487946 created "2016-06-24" @default.
• W2004487946 creator A5008546813 @default.
• W2004487946 creator A5023302753 @default.
• W2004487946 creator A5028630779 @default.
• W2004487946 creator A5031906182 @default.
• W2004487946 creator A5036414175 @default.
• W2004487946 creator A5042280654 @default.
• W2004487946 creator A5047475750 @default.
• W2004487946 creator A5055477708 @default.
• W2004487946 creator A5064913051 @default.
• W2004487946 creator A5073830184 @default.
• W2004487946 creator A5085629666 @default.
• W2004487946 creator A5086692435 @default.
• W2004487946 date "2010-08-27" @default.
• W2004487946 modified "2023-10-15" @default.
• W2004487946 title "A positive role for c-Abl in Atm and Atr activation in DNA damage response" @default.
• W2004487946 cites W1590583667 @default.
• W2004487946 cites W1939117974 @default.
• W2004487946 cites W1965559955 @default.
• W2004487946 cites W1966567462 @default.
• W2004487946 cites W1967232610 @default.
• W2004487946 cites W1967630574 @default.
• W2004487946 cites W1968376359 @default.
• W2004487946 cites W1973085375 @default.
• W2004487946 cites W1978183360 @default.
• W2004487946 cites W1979989319 @default.
• W2004487946 cites W1987577420 @default.
• W2004487946 cites W2003411878 @default.
• W2004487946 cites W2009747291 @default.
• W2004487946 cites W2012440354 @default.
• W2004487946 cites W2022539205 @default.
• W2004487946 cites W2030075101 @default.
• W2004487946 cites W2031863792 @default.
• W2004487946 cites W2060527795 @default.
• W2004487946 cites W2069201630 @default.
• W2004487946 cites W2074615071 @default.
• W2004487946 cites W2074968485 @default.
• W2004487946 cites W2075216432 @default.
• W2004487946 cites W2096003848 @default.
• W2004487946 cites W2106087857 @default.
• W2004487946 cites W2110235974 @default.
• W2004487946 cites W2111420919 @default.
• W2004487946 cites W2111772438 @default.
• W2004487946 cites W2122317160 @default.
• W2004487946 cites W2127720624 @default.
• W2004487946 cites W2128252882 @default.
• W2004487946 cites W2131646714 @default.
• W2004487946 cites W2135269077 @default.
• W2004487946 cites W2148172964 @default.
• W2004487946 cites W2150149139 @default.
• W2004487946 cites W2158917914 @default.
• W2004487946 cites W2162439328 @default.
• W2004487946 cites W2167545422 @default.
• W2004487946 cites W2170321545 @default.
• W2004487946 doi "https://doi.org/10.1038/cdd.2010.106" @default.
• W2004487946 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3131864" @default.
• W2004487946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20798688" @default.
• W2004487946 hasPublicationYear "2010" @default.
• W2004487946 type Work @default.
• W2004487946 sameAs 2004487946 @default.
• W2004487946 citedByCount "84" @default.
• W2004487946 countsByYear W20044879462012 @default.
• W2004487946 countsByYear W20044879462013 @default.
• W2004487946 countsByYear W20044879462014 @default.
• W2004487946 countsByYear W20044879462015 @default.
• W2004487946 countsByYear W20044879462016 @default.
• W2004487946 countsByYear W20044879462017 @default.
• W2004487946 countsByYear W20044879462018 @default.
• W2004487946 countsByYear W20044879462020 @default.
• W2004487946 countsByYear W20044879462021 @default.
• W2004487946 countsByYear W20044879462022 @default.
• W2004487946 countsByYear W20044879462023 @default.
• W2004487946 crossrefType "journal-article" @default.
• W2004487946 hasAuthorship W2004487946A5008546813 @default.
• W2004487946 hasAuthorship W2004487946A5023302753 @default.
• W2004487946 hasAuthorship W2004487946A5028630779 @default.
• W2004487946 hasAuthorship W2004487946A5031906182 @default.
• W2004487946 hasAuthorship W2004487946A5036414175 @default.
• W2004487946 hasAuthorship W2004487946A5042280654 @default.
• W2004487946 hasAuthorship W2004487946A5047475750 @default.
• W2004487946 hasAuthorship W2004487946A5055477708 @default.
• W2004487946 hasAuthorship W2004487946A5064913051 @default.
• W2004487946 hasAuthorship W2004487946A5073830184 @default.
• W2004487946 hasAuthorship W2004487946A5085629666 @default.
• W2004487946 hasAuthorship W2004487946A5086692435 @default.
• W2004487946 hasBestOaLocation W20044879461 @default.
• W2004487946 hasConcept C105696609 @default.
• W2004487946 hasConcept C11960822 @default.
• W2004487946 hasConcept C125418893 @default.
• W2004487946 hasConcept C134935766 @default.
• W2004487946 hasConcept C143425029 @default.
• W2004487946 hasConcept C185592680 @default.
• W2004487946 hasConcept C190283241 @default.
• W2004487946 hasConcept C29537977 @default.
• W2004487946 hasConcept C42362537 @default.
• W2004487946 hasConcept C50001416 @default.
• W2004487946 hasConcept C552990157 @default.

• next