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• W2004491550 abstract "Oncogenic transformation of normal cells often involves epigenetic alterations, including histone modification and DNA methylation. We conducted whole-genome bisulfite sequencing to determine the DNA methylomes of normal breast, fibroadenoma, invasive ductal carcinomas and MCF7. The emergence, disappearance, expansion and contraction of kilobase-sized hypomethylated regions (HMRs) and the hypomethylation of the megabase-sized partially methylated domains (PMDs) are the major forms of methylation changes observed in breast tumor samples. Hierarchical clustering of HMR revealed tumor-specific hypermethylated clusters and differential methylated enhancers specific to normal or breast cancer cell lines. Joint analysis of gene expression and DNA methylation data of normal breast and breast cancer cells identified differentially methylated and expressed genes associated with breast and/or ovarian cancers in cancer-specific HMR clusters. Furthermore, aberrant patterns of X-chromosome inactivation (XCI) was found in breast cancer cell lines as well as breast tumor samples in the TCGA BRCA (breast invasive carcinoma) dataset. They were characterized with differentially hypermethylated XIST promoter, reduced expression of XIST, and over-expression of hypomethylated X-linked genes. High expressions of these genes were significantly associated with lower survival rates in breast cancer patients. Comprehensive analysis of the normal and breast tumor methylomes suggests selective targeting of DNA methylation changes during breast cancer progression. The weak causal relationship between DNA methylation and gene expression observed in this study is evident of more complex role of DNA methylation in the regulation of gene expression in human epigenetics that deserves further investigation." @default.
• W2004491550 created "2016-06-24" @default.
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• W2004491550 date "2015-02-23" @default.
• W2004491550 modified "2023-09-27" @default.
• W2004491550 title "Hierarchical Clustering of Breast Cancer Methylomes Revealed Differentially Methylated and Expressed Breast Cancer Genes" @default.
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• W2004491550 cites W1964973808 @default.
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• W2004491550 cites W1967841068 @default.
• W2004491550 cites W1976626368 @default.
• W2004491550 cites W1982629186 @default.
• W2004491550 cites W1984562049 @default.
• W2004491550 cites W1986849101 @default.
• W2004491550 cites W1995002306 @default.
• W2004491550 cites W1995316111 @default.
• W2004491550 cites W2002497918 @default.
• W2004491550 cites W2003289983 @default.
• W2004491550 cites W2004729058 @default.
• W2004491550 cites W2008551935 @default.
• W2004491550 cites W2013709205 @default.
• W2004491550 cites W2014260136 @default.
• W2004491550 cites W2019229253 @default.
• W2004491550 cites W2027436927 @default.
• W2004491550 cites W2028907427 @default.
• W2004491550 cites W2029197798 @default.
• W2004491550 cites W2037966798 @default.
• W2004491550 cites W2049907774 @default.
• W2004491550 cites W2051208524 @default.
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• W2004491550 cites W2056389138 @default.
• W2004491550 cites W2059099579 @default.
• W2004491550 cites W2069717852 @default.
• W2004491550 cites W2077982494 @default.
• W2004491550 cites W2085934079 @default.
• W2004491550 cites W2097626332 @default.
• W2004491550 cites W2099343472 @default.
• W2004491550 cites W2101071606 @default.
• W2004491550 cites W2101366183 @default.
• W2004491550 cites W2102868331 @default.
• W2004491550 cites W2102983187 @default.
• W2004491550 cites W2113588666 @default.
• W2004491550 cites W2114104545 @default.
• W2004491550 cites W2114912562 @default.
• W2004491550 cites W2115252759 @default.
• W2004491550 cites W2117347068 @default.
• W2004491550 cites W2121417064 @default.
• W2004491550 cites W2121539520 @default.
• W2004491550 cites W2126731001 @default.
• W2004491550 cites W2128815309 @default.
• W2004491550 cites W2130722148 @default.
• W2004491550 cites W2136469817 @default.
• W2004491550 cites W2136959508 @default.
• W2004491550 cites W2138207763 @default.
• W2004491550 cites W2139077902 @default.
• W2004491550 cites W2141410747 @default.
• W2004491550 cites W2141758639 @default.
• W2004491550 cites W2144027697 @default.
• W2004491550 cites W2148521032 @default.
• W2004491550 cites W2150128901 @default.
• W2004491550 cites W2152220867 @default.
• W2004491550 cites W2157465258 @default.
• W2004491550 cites W2161062193 @default.
• W2004491550 cites W2161224111 @default.
• W2004491550 cites W2162871183 @default.
• W2004491550 cites W2163327652 @default.
• W2004491550 cites W2165101781 @default.
• W2004491550 cites W2165184227 @default.
• W2004491550 cites W2165286055 @default.
• W2004491550 cites W2166389246 @default.
• W2004491550 cites W2169456326 @default.
• W2004491550 cites W2170551349 @default.
• W2004491550 cites W2170574784 @default.
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• W2004491550 doi "https://doi.org/10.1371/journal.pone.0118453" @default.
• W2004491550 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4338251" @default.
• W2004491550 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25706888" @default.
• W2004491550 hasPublicationYear "2015" @default.
• W2004491550 type Work @default.

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