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- W2004497217 abstract "The emerging role of astrocytes in neural communication represents a conceptual challenge. In striking contrast to the rapid and highly space- and time-constrained machinery of neuronal spike propagation and synaptic release, astroglia appear slow and imprecise. Although a large body of independent experiments documents active signal exchange between astrocytes and neurons, some genetic models have raised doubts about the major Ca 2+ -dependent molecular mechanism routinely associated with release of “gliotransmitters.” A limited understanding of astrocytic Ca 2+ signaling and the imperfect compatibility between physiology and experimental manipulations seem to have contributed to this conceptual bottleneck. Experimental approaches providing mechanistic insights into the diverse mechanisms of intra-astrocyte Ca 2+ signaling on the nanoscale are needed to understand Ca 2+ -dependent astrocytic function in vivo. This review highlights limitations and potential advantages of such approaches from the current methodological perspective." @default.
- W2004497217 created "2016-06-24" @default.
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- W2004497217 creator A5015137977 @default.
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- W2004497217 date "2011-05-02" @default.
- W2004497217 modified "2023-09-26" @default.
- W2004497217 title "Astrocytes as Regulators of Synaptic Function" @default.
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- W2004497217 doi "https://doi.org/10.1177/1073858410387304" @default.
- W2004497217 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3374854" @default.
- W2004497217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21536839" @default.
- W2004497217 hasPublicationYear "2011" @default.
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