FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004500802> ?p ?o ?g. }

• W2004500802 endingPage "4403" @default.
• W2004500802 startingPage "4396" @default.
• W2004500802 abstract "Inhibitors of the Hsp90 molecular chaperone are showing considerable promise as potential molecular therapeutic agents for the treatment of cancer. Here we describe the identification of novel small molecular weight inhibitors of Hsp90 using a fragment based approach. Fragments were selected by docking, tested in a biochemical assay and the confirmed hits were crystallized. Information gained from X-ray structures of these fragments and other chemotypes was used to drive the fragment evolution process. Optimization of these high μM binders resulted in 3-benzylindazole derivatives with significantly improved affinity and anti-proliferative effects in different human cancer cell lines." @default.
• W2004500802 created "2016-06-24" @default.
• W2004500802 creator A5000853292 @default.
• W2004500802 creator A5011662854 @default.
• W2004500802 creator A5012764076 @default.
• W2004500802 creator A5037127062 @default.
• W2004500802 creator A5040507490 @default.
• W2004500802 creator A5061568567 @default.
• W2004500802 creator A5064295295 @default.
• W2004500802 creator A5066535320 @default.
• W2004500802 creator A5073610010 @default.
• W2004500802 creator A5074804047 @default.
• W2004500802 creator A5080482492 @default.
• W2004500802 creator A5089491665 @default.
• W2004500802 date "2012-07-01" @default.
• W2004500802 modified "2023-10-07" @default.
• W2004500802 title "Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90" @default.
• W2004500802 cites W1546236098 @default.
• W2004500802 cites W1586440254 @default.
• W2004500802 cites W1987988797 @default.
• W2004500802 cites W1995486038 @default.
• W2004500802 cites W1996100382 @default.
• W2004500802 cites W1998863708 @default.
• W2004500802 cites W1999715990 @default.
• W2004500802 cites W2008312146 @default.
• W2004500802 cites W2008525757 @default.
• W2004500802 cites W2014989916 @default.
• W2004500802 cites W2019839071 @default.
• W2004500802 cites W2022531767 @default.
• W2004500802 cites W2027770426 @default.
• W2004500802 cites W2029754521 @default.
• W2004500802 cites W2034269086 @default.
• W2004500802 cites W2059716720 @default.
• W2004500802 cites W2069554486 @default.
• W2004500802 cites W2079139546 @default.
• W2004500802 cites W2079875971 @default.
• W2004500802 cites W2086185470 @default.
• W2004500802 cites W2111187586 @default.
• W2004500802 cites W2112417555 @default.
• W2004500802 cites W2113007147 @default.
• W2004500802 cites W2113184090 @default.
• W2004500802 cites W2114779636 @default.
• W2004500802 cites W2121359315 @default.
• W2004500802 cites W2129004089 @default.
• W2004500802 cites W2136966549 @default.
• W2004500802 cites W2139306838 @default.
• W2004500802 cites W2141715793 @default.
• W2004500802 cites W2151204888 @default.
• W2004500802 cites W2175029576 @default.
• W2004500802 cites W2978691901 @default.
• W2004500802 doi "https://doi.org/10.1016/j.bmcl.2012.04.121" @default.
• W2004500802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22632933" @default.
• W2004500802 hasPublicationYear "2012" @default.
• W2004500802 type Work @default.
• W2004500802 sameAs 2004500802 @default.
• W2004500802 citedByCount "18" @default.
• W2004500802 countsByYear W20045008022012 @default.
• W2004500802 countsByYear W20045008022013 @default.
• W2004500802 countsByYear W20045008022014 @default.
• W2004500802 countsByYear W20045008022015 @default.
• W2004500802 countsByYear W20045008022016 @default.
• W2004500802 countsByYear W20045008022017 @default.
• W2004500802 countsByYear W20045008022018 @default.
• W2004500802 countsByYear W20045008022019 @default.
• W2004500802 countsByYear W20045008022021 @default.
• W2004500802 countsByYear W20045008022022 @default.
• W2004500802 countsByYear W20045008022023 @default.
• W2004500802 crossrefType "journal-article" @default.
• W2004500802 hasAuthorship W2004500802A5000853292 @default.
• W2004500802 hasAuthorship W2004500802A5011662854 @default.
• W2004500802 hasAuthorship W2004500802A5012764076 @default.
• W2004500802 hasAuthorship W2004500802A5037127062 @default.
• W2004500802 hasAuthorship W2004500802A5040507490 @default.
• W2004500802 hasAuthorship W2004500802A5061568567 @default.
• W2004500802 hasAuthorship W2004500802A5064295295 @default.
• W2004500802 hasAuthorship W2004500802A5066535320 @default.
• W2004500802 hasAuthorship W2004500802A5073610010 @default.
• W2004500802 hasAuthorship W2004500802A5074804047 @default.
• W2004500802 hasAuthorship W2004500802A5080482492 @default.
• W2004500802 hasAuthorship W2004500802A5089491665 @default.
• W2004500802 hasConcept C104317684 @default.
• W2004500802 hasConcept C161624437 @default.
• W2004500802 hasConcept C185592680 @default.
• W2004500802 hasConcept C199360897 @default.
• W2004500802 hasConcept C205260736 @default.
• W2004500802 hasConcept C21951064 @default.
• W2004500802 hasConcept C2775932338 @default.
• W2004500802 hasConcept C2776235265 @default.
• W2004500802 hasConcept C2777560012 @default.
• W2004500802 hasConcept C2780591553 @default.
• W2004500802 hasConcept C41008148 @default.
• W2004500802 hasConcept C55493867 @default.
• W2004500802 hasConcept C70721500 @default.
• W2004500802 hasConcept C71240020 @default.
• W2004500802 hasConcept C74187038 @default.
• W2004500802 hasConcept C86803240 @default.
• W2004500802 hasConceptScore W2004500802C104317684 @default.
• W2004500802 hasConceptScore W2004500802C161624437 @default.

• next