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• W2004503019 abstract "Abstract The uptake of Gadomer‐17, as probed by fast dynamic T 1 measurements, was used to assess the vascular permeability surface‐area product per leakage volume of tissue (k Tofts ) of human glioma xenografts implanted in mice. With this approach we could discriminate between two types of glioma xenograft lines with a known difference in the perfused vascular architecture and degree of hypoxia. The T 1 data were analyzed according to the Tofts‐Kermode compartment model. The fast‐growing E102 tumor demonstrated a homogeneous distribution of the vascular permeability surface area across the tumor (mean k Tofts value = 0.18 ± 0.05 min −1 ). The slowly growing E106 tumor showed a more heterogeneous pattern. Three perfused tumor areas with differences in vascular permeability surface area could be distinguished: a well‐perfused periphery with high k Tofts values (0.24 ± 0.04 min −1 ), perfused capillaries inside the tumor with low k Tofts values (0.108 ± 0.026 min −1 ), and perfused capillaries adjacent to necrotic regions with high k Tofts values (0.29 ± 0.10 min −1 ). On a different series of tumors, the hypoxic fractions were measured, and these were significantly higher in E106 tumors (0.14 ± 0.05) compared to tumors of the E102 line (0.03 ± 0.02). Magn Reson Med 47:305–313, 2002. © 2002 Wiley‐Liss, Inc." @default.
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• W2004503019 date "2002-01-23" @default.
• W2004503019 modified "2023-10-18" @default.
• W2004503019 title "Assessment of the neovascular permeability in glioma xenografts by dynamic<i>T</i>₁MRI with Gadomer-17" @default.
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• W2004503019 doi "https://doi.org/10.1002/mrm.10072" @default.
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