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• W2004507883 endingPage "268" @default.
• W2004507883 startingPage "263" @default.
• W2004507883 abstract "Risedronate, an anti-osteoporotic drug, is associated with low patient compliance due to the upper gastrointestinal side-effects and stringent dosing regimes. This study aimed to prepare and characterize risedronate-loaded Eudragit® S100 microparticles and develop a final dosage form by the compression of microparticles using direct tableting excipients. Microparticles were prepared by spray-drying and presented yield of 54%, encapsulation efficiency higher than 90%, mean diameter of 3.3 µm, moisture content around 8% and exhibited spherical shape and poor flowability. At pH 1.2, 23% of risedronate was released from microparticles in 120 min, while at pH 6.8 the drug took 90 min to reach 99.5%. Microparticles were compressed into tablets using microcrystalline cellulose, magnesium stearate, colloidal silicon dioxide and 2 polyvinylpyrrolidone concentrations (5% and 15%). Tablets presented low variations in weight, thickness and drug content. Besides, the formulations showed sufficient hardness, low friability and disintegrated in less than 15 min. In acid medium, no more than 16% of the drug was released in 120 min, while in intestinal medium the formulations prolonged the risedronate release for 240 min. Finally, the developed tableted microparticles can be considered a promising dosage form for oral risedronate administration." @default.
• W2004507883 created "2016-06-24" @default.
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• W2004507883 date "2013-03-19" @default.
• W2004507883 modified "2023-09-26" @default.
• W2004507883 title "Risedronate-loaded Eudragit S100 microparticles formulated into tablets" @default.
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• W2004507883 doi "https://doi.org/10.3109/10837450.2013.775155" @default.
• W2004507883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23506303" @default.
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