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- W2004532181 abstract "In human cancers, all cancerous cells carry the oncogenic genetic lesions. However, to elucidate whether cancer is a stem cell-driven tissue, we have developed a strategy to limit oncogene expression to the stem cell compartment in a transgenic mouse setting. Here, we focus on the effects of the BCR-ABLp210 oncogene, associated with chronic myeloid leukaemia (CML) in humans. We show that CML phenotype and biology can be established in mice by restricting BCR-ABLp210 expression to stem cell antigen 1 (Sca1)(+) cells. The course of the disease in Sca1-BCR-ABLp210 mice was not modified on STI571 treatment. However, BCR-ABLp210-induced CML is reversible through the unique elimination of the cancer stem cells (CSCs). Overall, our data show that oncogene expression in Sca1(+) cells is all that is required to fully reprogramme it, giving rise to a full-blown, oncogene-specified tumour with all its mature cellular diversity, and that elimination of the CSCs is enough to eradicate the whole tumour." @default.
- W2004532181 created "2016-06-24" @default.
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- W2004532181 date "2008-11-27" @default.
- W2004532181 modified "2023-10-17" @default.
- W2004532181 title "Cancer induction by restriction of oncogene expression to the stem cell compartment" @default.
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- W2004532181 doi "https://doi.org/10.1038/emboj.2008.253" @default.
- W2004532181 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2600654" @default.
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