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- W2004534663 abstract "The SO42− flux across the erythrocyte membrane can be inhibited by various organic substances such as phenol, benzoate, phlorhizin and dipyridamol. The inhibition is noncompetitive and reversible. The SO42− flux exhibits a strong pH dependence (maximum at pH 6.3, inflection point at pH 6.9) which can be removed almost completely by high doses of the inhibitors. The fractional inhibition of the SO42− flux has a pH optimum at about pH 7.0. The apparent activation energy of the SO42− transition is about 33 kcal/mole. It is independent of pH and not affected by the inhibitors salicylate, benzoate, phlorhizin and dipyridamol. On the basis of the fixed-charge hypothesis of the erythrocyte membrane an equation is derived which enables the calculation of the sulfate concentration SO4m2− within the fixed-charge layer of the erythrocyte membrane. 2SO4m2− + pSO2m2−=A·qK(i+I0/KiSO4m2− +qĀ = 2.5 M and K = 1·10−9 M denote the concentration of amino groups in the fixed-charge layer and their dissociation constant, respectively, I0 the inhibitor concentration in the outside solution, and Ki the inhibition constant. p = Cl0−/√SO4m2− and q = H0+·√SO402−, SO402−, Cl0− and H0+ are the concentrations of SO42−, Cl− and H+ in the outside solution, respectively. The relation between the SO42− flux JSO4 and SO4m2− is JSO4= Jo· exp aSO4M2− At 37 °C J0 = 1·10−8 moles·min−1·g−1 cells, a = 4.6 M−1. Ki (benzoate) = 5·10−3 M and Ki (dipyridamol) = 1·10−6 M gave the best fit to our experimental data. J0 and a are not significantly affected by the inhibitors benzoate and dipyridamol. The results suggest that compounds which cannot react covalently with amino groups inhibit the SO42− flux by a reduction of the effective fixed-charge density of the erythrocyte membrane and a consequent reduction of SO4m2−." @default.
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- W2004534663 date "1972-09-01" @default.
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- W2004534663 title "On the mechanism of inhibition of the sulfate transfer across the human erythrocyte membrane" @default.
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- W2004534663 doi "https://doi.org/10.1016/0005-2736(72)90333-1" @default.
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