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- W2004535570 abstract "Abstract In hepatocytes isolated from fed rats, low concentrations of oxalate (50 to 100 μM) greatly enhance ketogenesis and decrease fatty acid synthesis. These metabolic changes are due to pyruvate carboxylase inhibition. Dichloroacetate, which can be catabolized into oxalate enhances ketogenesis only when cells are enriched with lactate and pyruvate and has no obvious effect on lipogenesis. The enhancement of ketogenesis, in both cases, is due to an imbalance between pyruvate dehydrogenase and pyruvate carboxylase but with oxalate, the primary event is oxaloacetate shortage and with dichloroacetate, mitochondrial acetyl CoA excess. This work demonstrates that the studied effects of dichloroacetate are not mediated by oxalate and that low concentrations of oxalate alter the lipid metabolism of hepatocytes." @default.
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- W2004535570 date "1982-02-01" @default.
- W2004535570 modified "2023-09-26" @default.
- W2004535570 title "Effects of oxalate and dichloroacetate on lipogenesis and ketogenesis in rat hepatocytes" @default.
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- W2004535570 doi "https://doi.org/10.1016/0006-291x(82)91364-x" @default.
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