FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004541472> ?p ?o ?g. }

• W2004541472 endingPage "68" @default.
• W2004541472 startingPage "61" @default.
• W2004541472 abstract "Addition of cytochrome b(5) to recombinant cytochrome P450 2E1 systems has been shown to enhance the metabolism of dialkylnitrosamines in vitro. To determine if this effect could be observed with recombinant expression systems in vivo, we have constructed mutagenicity tester strains that coexpress full-length human cytochrome P450 2E1 (CYP2E1), rat cytochrome P450 reductase, and human cytochrome b(5) in Salmonella typhimurium lacking ogt and ada methyltransferases (YG7104, ogt(-); and YG7108, ogt(-), ada(-)). These new recombinant strains exhibit a four- to five-fold greater mutagenic response to dimethylnitrosamine, diethylnitrosamine, and dipropylnitrosamine than strains that contain only CYP2E1 and reductase, and are over 100-fold more sensitive to nitrosamines than the parental strains in the presence of an exogenous activating system (S9 fraction). The four-fold increase in mutagenicity in the presence of cytochrome b(5) was consistent with increasing alkyl chain length up to dibutylnitrosamine, which was poorly activated by CYP2E1. The greatest enhancement was obtained with a tricistronic construct in which the b(5) cDNA preceded the P450 and reductase cDNAs; placing the b(5) cDNA after the reductase cDNA was substantially less effective. These new, highly sensitive strains may prove useful in the detection of nitrosamine contamination of food and environmental samples." @default.
• W2004541472 created "2016-06-24" @default.
• W2004541472 creator A5055797259 @default.
• W2004541472 creator A5084226349 @default.
• W2004541472 date "2001-12-01" @default.
• W2004541472 modified "2023-09-30" @default.
• W2004541472 title "Cytochrome b5 coexpression increases the CYP2E1-dependent mutagenicity of dialkylnitrosamines in methyltransferase-deficient strains of Salmonella typhimurium" @default.
• W2004541472 cites W1535133733 @default.
• W2004541472 cites W1547700271 @default.
• W2004541472 cites W1597669330 @default.
• W2004541472 cites W1966003491 @default.
• W2004541472 cites W1979596584 @default.
• W2004541472 cites W1979943338 @default.
• W2004541472 cites W1993465296 @default.
• W2004541472 cites W1994460876 @default.
• W2004541472 cites W2001295352 @default.
• W2004541472 cites W2003525899 @default.
• W2004541472 cites W2013394321 @default.
• W2004541472 cites W2014970345 @default.
• W2004541472 cites W2016385773 @default.
• W2004541472 cites W2029345108 @default.
• W2004541472 cites W2031057261 @default.
• W2004541472 cites W2039021283 @default.
• W2004541472 cites W2039677216 @default.
• W2004541472 cites W2041617487 @default.
• W2004541472 cites W2043100189 @default.
• W2004541472 cites W2055994283 @default.
• W2004541472 cites W2066600629 @default.
• W2004541472 cites W2082802949 @default.
• W2004541472 cites W2095132189 @default.
• W2004541472 cites W2121795080 @default.
• W2004541472 cites W2126733133 @default.
• W2004541472 cites W2169167768 @default.
• W2004541472 cites W2169891444 @default.
• W2004541472 cites W83110935 @default.
• W2004541472 doi "https://doi.org/10.1016/s0027-5107(01)00236-6" @default.
• W2004541472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11733072" @default.
• W2004541472 hasPublicationYear "2001" @default.
• W2004541472 type Work @default.
• W2004541472 sameAs 2004541472 @default.
• W2004541472 citedByCount "16" @default.
• W2004541472 countsByYear W20045414722012 @default.
• W2004541472 countsByYear W20045414722013 @default.
• W2004541472 countsByYear W20045414722015 @default.
• W2004541472 countsByYear W20045414722016 @default.
• W2004541472 crossrefType "journal-article" @default.
• W2004541472 hasAuthorship W2004541472A5055797259 @default.
• W2004541472 hasAuthorship W2004541472A5084226349 @default.
• W2004541472 hasConcept C104317684 @default.
• W2004541472 hasConcept C134651460 @default.
• W2004541472 hasConcept C140027455 @default.
• W2004541472 hasConcept C148292235 @default.
• W2004541472 hasConcept C153911025 @default.
• W2004541472 hasConcept C171305022 @default.
• W2004541472 hasConcept C181199279 @default.
• W2004541472 hasConcept C185592680 @default.
• W2004541472 hasConcept C187882448 @default.
• W2004541472 hasConcept C24586158 @default.
• W2004541472 hasConcept C2779384962 @default.
• W2004541472 hasConcept C2780768313 @default.
• W2004541472 hasConcept C2781065037 @default.
• W2004541472 hasConcept C40767141 @default.
• W2004541472 hasConcept C523546767 @default.
• W2004541472 hasConcept C526171541 @default.
• W2004541472 hasConcept C54355233 @default.
• W2004541472 hasConcept C55493867 @default.
• W2004541472 hasConcept C86803240 @default.
• W2004541472 hasConceptScore W2004541472C104317684 @default.
• W2004541472 hasConceptScore W2004541472C134651460 @default.
• W2004541472 hasConceptScore W2004541472C140027455 @default.
• W2004541472 hasConceptScore W2004541472C148292235 @default.
• W2004541472 hasConceptScore W2004541472C153911025 @default.
• W2004541472 hasConceptScore W2004541472C171305022 @default.
• W2004541472 hasConceptScore W2004541472C181199279 @default.
• W2004541472 hasConceptScore W2004541472C185592680 @default.
• W2004541472 hasConceptScore W2004541472C187882448 @default.
• W2004541472 hasConceptScore W2004541472C24586158 @default.
• W2004541472 hasConceptScore W2004541472C2779384962 @default.
• W2004541472 hasConceptScore W2004541472C2780768313 @default.
• W2004541472 hasConceptScore W2004541472C2781065037 @default.
• W2004541472 hasConceptScore W2004541472C40767141 @default.
• W2004541472 hasConceptScore W2004541472C523546767 @default.
• W2004541472 hasConceptScore W2004541472C526171541 @default.
• W2004541472 hasConceptScore W2004541472C54355233 @default.
• W2004541472 hasConceptScore W2004541472C55493867 @default.
• W2004541472 hasConceptScore W2004541472C86803240 @default.
• W2004541472 hasIssue "1-2" @default.
• W2004541472 hasLocation W20045414721 @default.
• W2004541472 hasLocation W20045414722 @default.
• W2004541472 hasOpenAccess W2004541472 @default.
• W2004541472 hasPrimaryLocation W20045414721 @default.
• W2004541472 hasRelatedWork W1982956495 @default.
• W2004541472 hasRelatedWork W1996147156 @default.
• W2004541472 hasRelatedWork W2004541472 @default.
• W2004541472 hasRelatedWork W2018873107 @default.
• W2004541472 hasRelatedWork W2082802949 @default.
• W2004541472 hasRelatedWork W2182235604 @default.
• W2004541472 hasRelatedWork W2325116090 @default.

• next