Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004542986> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2004542986 endingPage "484" @default.
- W2004542986 startingPage "479" @default.
- W2004542986 abstract "Objectives: Cisplatin, 5-fluorouracil (5-FU) and docetaxel are active agents in the treatment of upper gastrointestinal malignancies. This phase I study was undertaken to determine the maximally tolerated dose and dose-limiting toxicities of a combination of these drugs given in an ambulatory setting using a bolus schedule of 5-FU. Methods: Twenty patients with gastrointestinal malignancies were treated with docetaxel on day 1, cisplatin on day 2 and bolus 5-FU with leucovorin each day for 5 days, without prophylactic antibiotics or colony-stimulating factors. The cycle was repeated at 21-day intervals. A dose-escalating phase I design was used. Results: There were two treatment-related deaths as a result of neutropenia and sepsis. The maximally tolerated dose was docetaxel at 60 mg/m2 on day 1, cisplatin at 75 mg/m2 on day 2 and 5-FU at 200 mg/m2 with leucovorin at 20 mg/m2 daily from day 1 to day 5. At this dose, neutropenia was occurring in 4 of 6 patients treated. There were three partial responses, 1 patient with esophagogastric cancer and 2 with gastric cancer. Conclusions: This regimen demonstrates efficacy in upper gastrointestinal malignancies. Strategies to improve the tolerance of these agents in combination should be pursued." @default.
- W2004542986 created "2016-06-24" @default.
- W2004542986 creator A5021904320 @default.
- W2004542986 creator A5029706633 @default.
- W2004542986 creator A5036972230 @default.
- W2004542986 creator A5053128814 @default.
- W2004542986 creator A5059298173 @default.
- W2004542986 date "2005-01-01" @default.
- W2004542986 modified "2023-09-26" @default.
- W2004542986 title "A Phase I Study of Docetaxel, Cisplatin, 5-Fluorouracil and Leucovorin" @default.
- W2004542986 cites W1585834668 @default.
- W2004542986 cites W1910716144 @default.
- W2004542986 cites W1968428706 @default.
- W2004542986 cites W1980244614 @default.
- W2004542986 cites W1999879350 @default.
- W2004542986 cites W2095995750 @default.
- W2004542986 cites W2123495698 @default.
- W2004542986 cites W2128775037 @default.
- W2004542986 cites W2137408681 @default.
- W2004542986 cites W2140626944 @default.
- W2004542986 cites W2170346929 @default.
- W2004542986 cites W2185943375 @default.
- W2004542986 cites W2203599654 @default.
- W2004542986 cites W2229238935 @default.
- W2004542986 doi "https://doi.org/10.1159/000086991" @default.
- W2004542986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16020978" @default.
- W2004542986 hasPublicationYear "2005" @default.
- W2004542986 type Work @default.
- W2004542986 sameAs 2004542986 @default.
- W2004542986 citedByCount "0" @default.
- W2004542986 crossrefType "journal-article" @default.
- W2004542986 hasAuthorship W2004542986A5021904320 @default.
- W2004542986 hasAuthorship W2004542986A5029706633 @default.
- W2004542986 hasAuthorship W2004542986A5036972230 @default.
- W2004542986 hasAuthorship W2004542986A5053128814 @default.
- W2004542986 hasAuthorship W2004542986A5059298173 @default.
- W2004542986 hasConcept C126322002 @default.
- W2004542986 hasConcept C143998085 @default.
- W2004542986 hasConcept C2776694085 @default.
- W2004542986 hasConcept C2778239845 @default.
- W2004542986 hasConcept C2780456651 @default.
- W2004542986 hasConcept C2781190966 @default.
- W2004542986 hasConcept C71924100 @default.
- W2004542986 hasConceptScore W2004542986C126322002 @default.
- W2004542986 hasConceptScore W2004542986C143998085 @default.
- W2004542986 hasConceptScore W2004542986C2776694085 @default.
- W2004542986 hasConceptScore W2004542986C2778239845 @default.
- W2004542986 hasConceptScore W2004542986C2780456651 @default.
- W2004542986 hasConceptScore W2004542986C2781190966 @default.
- W2004542986 hasConceptScore W2004542986C71924100 @default.
- W2004542986 hasIssue "4-6" @default.
- W2004542986 hasLocation W20045429861 @default.
- W2004542986 hasLocation W20045429862 @default.
- W2004542986 hasOpenAccess W2004542986 @default.
- W2004542986 hasPrimaryLocation W20045429861 @default.
- W2004542986 hasRelatedWork W1998091677 @default.
- W2004542986 hasRelatedWork W2010125764 @default.
- W2004542986 hasRelatedWork W2064773437 @default.
- W2004542986 hasRelatedWork W2160755302 @default.
- W2004542986 hasRelatedWork W2169948128 @default.
- W2004542986 hasRelatedWork W2279916335 @default.
- W2004542986 hasRelatedWork W2348256461 @default.
- W2004542986 hasRelatedWork W2999789808 @default.
- W2004542986 hasRelatedWork W3030044048 @default.
- W2004542986 hasRelatedWork W3141524493 @default.
- W2004542986 hasVolume "68" @default.
- W2004542986 isParatext "false" @default.
- W2004542986 isRetracted "false" @default.
- W2004542986 magId "2004542986" @default.
- W2004542986 workType "article" @default.