Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004545577> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2004545577 endingPage "62" @default.
- W2004545577 startingPage "57" @default.
- W2004545577 abstract "To assess the relative safety of chronically administered chlorine water disinfectants in man, a controlled study was undertaken. The clinical evaluation was conducted in the three phases common to investigational drug studies. Phase I, a rising dose tolerance investigation, examined the acute effects of progressively increasing single doses of chlorine disinfectants to normal healthy adult male volunteers. Phase II considered the impact on normal subjects of daily ingestion of the disinfectants at a concentration of 5 mg/l. for twelve consecutive weeks. Persons with a low level of glucose-6-phosphate dehydrogenase may be expected to be especially susceptible to oxidative stress; therefore, in Phase III, chlorite at a concentration of 5 mg/l. was administered daily for twelve consecutive weeks to a small group of potentially at-risk glucose-6-phosphate dehydrogenase-deficient subjects. Physiological impact was assessed by evaluation of a battery of qualitative and quantitative tests. The three phases of this controlled double-blind clinical evaluation of chlorine dioxide and its potential metabolites in human male volunteer subjects were completed uneventfully. There were no obvious undesirable clinical sequellae noted by any of the participating subjects or by the observing medical team. In several cases, statistically significant trends in certain biochemical or physiological parameters were associated with treatment; however, none of these trends was judged to have physiological consequence. One cannot rule out the possibility that, over a longer treatment period, these trends might indeed achieve proportions of clinical importance. However, by the absence of detrimental physiological responses within the limits of the study, the relative safety of oral ingestion of chlorine dioxide and its metabolites, chlorite and chlorate, was demonstrated." @default.
- W2004545577 created "2016-06-24" @default.
- W2004545577 creator A5005031625 @default.
- W2004545577 creator A5040352642 @default.
- W2004545577 creator A5041112816 @default.
- W2004545577 date "1982-12-01" @default.
- W2004545577 modified "2023-10-17" @default.
- W2004545577 title "Controlled clinical evaluations of chlorine dioxide, chlorite and chlorate in man." @default.
- W2004545577 cites W1978076727 @default.
- W2004545577 cites W1996892739 @default.
- W2004545577 cites W2010665686 @default.
- W2004545577 cites W2024753211 @default.
- W2004545577 cites W2336517096 @default.
- W2004545577 cites W2409148383 @default.
- W2004545577 cites W2410016629 @default.
- W2004545577 cites W2415706985 @default.
- W2004545577 cites W2417720796 @default.
- W2004545577 cites W2463429094 @default.
- W2004545577 doi "https://doi.org/10.1289/ehp.824657" @default.
- W2004545577 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1569027" @default.
- W2004545577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6961033" @default.
- W2004545577 hasPublicationYear "1982" @default.
- W2004545577 type Work @default.
- W2004545577 sameAs 2004545577 @default.
- W2004545577 citedByCount "39" @default.
- W2004545577 countsByYear W20045455772012 @default.
- W2004545577 countsByYear W20045455772013 @default.
- W2004545577 countsByYear W20045455772016 @default.
- W2004545577 countsByYear W20045455772020 @default.
- W2004545577 countsByYear W20045455772021 @default.
- W2004545577 countsByYear W20045455772022 @default.
- W2004545577 crossrefType "journal-article" @default.
- W2004545577 hasAuthorship W2004545577A5005031625 @default.
- W2004545577 hasAuthorship W2004545577A5040352642 @default.
- W2004545577 hasAuthorship W2004545577A5041112816 @default.
- W2004545577 hasBestOaLocation W20045455771 @default.
- W2004545577 hasConcept C126322002 @default.
- W2004545577 hasConcept C178790620 @default.
- W2004545577 hasConcept C179104552 @default.
- W2004545577 hasConcept C185592680 @default.
- W2004545577 hasConcept C193230392 @default.
- W2004545577 hasConcept C2776768635 @default.
- W2004545577 hasConcept C2778894954 @default.
- W2004545577 hasConcept C2780399513 @default.
- W2004545577 hasConcept C33070731 @default.
- W2004545577 hasConcept C42407357 @default.
- W2004545577 hasConcept C505241676 @default.
- W2004545577 hasConcept C6557445 @default.
- W2004545577 hasConcept C71924100 @default.
- W2004545577 hasConcept C86803240 @default.
- W2004545577 hasConceptScore W2004545577C126322002 @default.
- W2004545577 hasConceptScore W2004545577C178790620 @default.
- W2004545577 hasConceptScore W2004545577C179104552 @default.
- W2004545577 hasConceptScore W2004545577C185592680 @default.
- W2004545577 hasConceptScore W2004545577C193230392 @default.
- W2004545577 hasConceptScore W2004545577C2776768635 @default.
- W2004545577 hasConceptScore W2004545577C2778894954 @default.
- W2004545577 hasConceptScore W2004545577C2780399513 @default.
- W2004545577 hasConceptScore W2004545577C33070731 @default.
- W2004545577 hasConceptScore W2004545577C42407357 @default.
- W2004545577 hasConceptScore W2004545577C505241676 @default.
- W2004545577 hasConceptScore W2004545577C6557445 @default.
- W2004545577 hasConceptScore W2004545577C71924100 @default.
- W2004545577 hasConceptScore W2004545577C86803240 @default.
- W2004545577 hasLocation W20045455771 @default.
- W2004545577 hasLocation W20045455772 @default.
- W2004545577 hasLocation W20045455773 @default.
- W2004545577 hasLocation W20045455774 @default.
- W2004545577 hasOpenAccess W2004545577 @default.
- W2004545577 hasPrimaryLocation W20045455771 @default.
- W2004545577 hasRelatedWork W1548532975 @default.
- W2004545577 hasRelatedWork W2004545577 @default.
- W2004545577 hasRelatedWork W2088922145 @default.
- W2004545577 hasRelatedWork W2352961175 @default.
- W2004545577 hasRelatedWork W2377386666 @default.
- W2004545577 hasRelatedWork W2390744775 @default.
- W2004545577 hasRelatedWork W40370966 @default.
- W2004545577 hasRelatedWork W4230081738 @default.
- W2004545577 hasRelatedWork W1964397575 @default.
- W2004545577 hasRelatedWork W2484983032 @default.
- W2004545577 hasVolume "46" @default.
- W2004545577 isParatext "false" @default.
- W2004545577 isRetracted "false" @default.
- W2004545577 magId "2004545577" @default.
- W2004545577 workType "article" @default.