Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004553600> ?p ?o ?g. }
- W2004553600 endingPage "54825" @default.
- W2004553600 startingPage "54817" @default.
- W2004553600 abstract "The Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is required for maintenance of the viral genome DNA during the latent phase of EBV replication but continues to be synthesized after the induction of viral productive replication. An EBV genome-wide chromatin immunoprecipitation assay revealed that EBNA1 constantly binds to oriP of the EBV genome during not only latent but also lytic infection. Although the total levels of EBNA1 proved constant throughout the latter, the levels of the oriP-bound form were increased as lytic infection proceeded. EBV productive DNA replication occurs at discrete sites in nuclei, called replication compartments, where viral replication proteins are clustered. Confocal laser microscopic analyses revealed that whereas EBNA1 was distributed broadly in nuclei as fine punctate dots during the latent phase of infection, the protein became redistributed to the viral replication compartments and localized as distinct spots within and/or nearby the compartments after the induction of lytic replication. Taking these findings into consideration, oriP regions of the EBV genome might be organized by EBNA1 into replication domains that may set up scaffolding for lytic replication and transcription." @default.
- W2004553600 created "2016-06-24" @default.
- W2004553600 creator A5008921302 @default.
- W2004553600 creator A5012531660 @default.
- W2004553600 creator A5016303850 @default.
- W2004553600 creator A5021381992 @default.
- W2004553600 creator A5032422461 @default.
- W2004553600 creator A5040899745 @default.
- W2004553600 date "2004-12-01" @default.
- W2004553600 modified "2023-10-03" @default.
- W2004553600 title "In Vivo Dynamics of EBNA1-oriP Interaction during Latent and Lytic Replication of Epstein-Barr Virus" @default.
- W2004553600 cites W134583318 @default.
- W2004553600 cites W1526922416 @default.
- W2004553600 cites W1543207966 @default.
- W2004553600 cites W1573217573 @default.
- W2004553600 cites W1594478849 @default.
- W2004553600 cites W1638141956 @default.
- W2004553600 cites W1786573368 @default.
- W2004553600 cites W1957748504 @default.
- W2004553600 cites W1959134117 @default.
- W2004553600 cites W1977437833 @default.
- W2004553600 cites W1979415657 @default.
- W2004553600 cites W1981922425 @default.
- W2004553600 cites W1983024867 @default.
- W2004553600 cites W1985971484 @default.
- W2004553600 cites W1995701262 @default.
- W2004553600 cites W1999244358 @default.
- W2004553600 cites W2015221134 @default.
- W2004553600 cites W2023441599 @default.
- W2004553600 cites W2033268617 @default.
- W2004553600 cites W2045327902 @default.
- W2004553600 cites W2045607467 @default.
- W2004553600 cites W2047197428 @default.
- W2004553600 cites W2051349452 @default.
- W2004553600 cites W2062507247 @default.
- W2004553600 cites W2078682316 @default.
- W2004553600 cites W2090985010 @default.
- W2004553600 cites W2096286842 @default.
- W2004553600 cites W2102755898 @default.
- W2004553600 cites W2108116883 @default.
- W2004553600 cites W2110250542 @default.
- W2004553600 cites W2111358633 @default.
- W2004553600 cites W2121524269 @default.
- W2004553600 cites W2126346731 @default.
- W2004553600 cites W2130455180 @default.
- W2004553600 cites W2138576404 @default.
- W2004553600 cites W2142611898 @default.
- W2004553600 cites W2143665924 @default.
- W2004553600 cites W2144753766 @default.
- W2004553600 cites W2162692975 @default.
- W2004553600 cites W2167123412 @default.
- W2004553600 cites W2293125395 @default.
- W2004553600 cites W2429416208 @default.
- W2004553600 doi "https://doi.org/10.1074/jbc.m405911200" @default.
- W2004553600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15498777" @default.
- W2004553600 hasPublicationYear "2004" @default.
- W2004553600 type Work @default.
- W2004553600 sameAs 2004553600 @default.
- W2004553600 citedByCount "27" @default.
- W2004553600 countsByYear W20045536002012 @default.
- W2004553600 countsByYear W20045536002013 @default.
- W2004553600 countsByYear W20045536002014 @default.
- W2004553600 countsByYear W20045536002015 @default.
- W2004553600 countsByYear W20045536002016 @default.
- W2004553600 countsByYear W20045536002020 @default.
- W2004553600 countsByYear W20045536002022 @default.
- W2004553600 crossrefType "journal-article" @default.
- W2004553600 hasAuthorship W2004553600A5008921302 @default.
- W2004553600 hasAuthorship W2004553600A5012531660 @default.
- W2004553600 hasAuthorship W2004553600A5016303850 @default.
- W2004553600 hasAuthorship W2004553600A5021381992 @default.
- W2004553600 hasAuthorship W2004553600A5032422461 @default.
- W2004553600 hasAuthorship W2004553600A5040899745 @default.
- W2004553600 hasBestOaLocation W20045536001 @default.
- W2004553600 hasConcept C121332964 @default.
- W2004553600 hasConcept C12590798 @default.
- W2004553600 hasConcept C140704245 @default.
- W2004553600 hasConcept C145912823 @default.
- W2004553600 hasConcept C159047783 @default.
- W2004553600 hasConcept C182615771 @default.
- W2004553600 hasConcept C207001950 @default.
- W2004553600 hasConcept C24890656 @default.
- W2004553600 hasConcept C2522874641 @default.
- W2004553600 hasConcept C54355233 @default.
- W2004553600 hasConcept C86803240 @default.
- W2004553600 hasConceptScore W2004553600C121332964 @default.
- W2004553600 hasConceptScore W2004553600C12590798 @default.
- W2004553600 hasConceptScore W2004553600C140704245 @default.
- W2004553600 hasConceptScore W2004553600C145912823 @default.
- W2004553600 hasConceptScore W2004553600C159047783 @default.
- W2004553600 hasConceptScore W2004553600C182615771 @default.
- W2004553600 hasConceptScore W2004553600C207001950 @default.
- W2004553600 hasConceptScore W2004553600C24890656 @default.
- W2004553600 hasConceptScore W2004553600C2522874641 @default.
- W2004553600 hasConceptScore W2004553600C54355233 @default.
- W2004553600 hasConceptScore W2004553600C86803240 @default.
- W2004553600 hasIssue "52" @default.
- W2004553600 hasLocation W20045536001 @default.