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- W2004555438 abstract "Parkinson's disease (PD) is a common neurodegenerative disorder characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta. Recent observations link cyclooxygenase type-2 (COX-2) to the progression of the disease. Consistent with this notion, studies with the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) show that inhibition and ablation of COX-2 markedly reduce the deleterious effects of this toxin on the nigrostriatal pathway. The similarity between this experimental model and PD strongly supports the possibility that COX-2 expression is also pathogenic in PD." @default.
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- W2004555438 date "2006-01-24" @default.
- W2004555438 modified "2023-10-01" @default.
- W2004555438 title "COX-2 and Neurodegeneration in Parkinson's Disease" @default.
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- W2004555438 doi "https://doi.org/10.1111/j.1749-6632.2003.tb07482.x" @default.
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