FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004555667> ?p ?o ?g. }

• W2004555667 endingPage "929" @default.
• W2004555667 startingPage "925" @default.
• W2004555667 abstract "Accurate chromosome partitioning during cell division requires that cohesion hold sister chromatids together until kinetochores correctly attach to spindle microtubules. In 1932, Darlington noted that sister-chromatid cohesion distal to the site of exchange also could play a vital role in maintaining the association of chiasmate homologs during meiosis [1Darlington C.D. Recent Advances in Cytology. Churchill, London1932Google Scholar]. Cohesion linking a recombinant chromatid with a sister of each homologous pair would resist spindle forces that separate kinetochores of homologous chromosomes (see Figure 1)Graphical AbstractSchematic of How Arm Cohesion Distal to the Site of a Crossover Event Can Maintain the Association of Homologous Chromosomes during MeiosisShow full captionEach set of homologs (light gray and dark gray) is composed of two sister chromatids held together along their entire length by cohesion (black cross bars).(A) After the homologs pair, recombination takes place. In this figure, a crossover has occurred on each arm.(B) During spindle assembly, homolog kinetochores attach to microtubules and are pulled toward the poles. Arm cohesion distal to the site of each crossover resists the forces acting to separate the homologous chromosomes.(C) At the onset of anaphase I, arm cohesion is released, allowing homologs to migrate to opposite poles. Centromeric cohesion between sisters remains intact until anaphase II and is required for proper segregation of sisters during the second meiotic division.View Large Image Figure ViewerDownload Hi-res image Download (PPT). Although centromeric cohesion must be retained to ensure proper segregation during meiosis II, dissolution of arm cohesion would be required for anaphase I to occur. This hypothesis is supported by recent evidence in yeast and C. elegans that separase activity is essential for the segregation of recombinant homologs during meiosis I [2Buonomo S.B. Clyne R.K. Fuchs J. Loidl J. Uhlmann F. Nasmyth K. Disjunction of homologous chromosomes in meiosis I depends on proteolytic cleavage of the meiotic cohesin Rec8 by separin.Cell. 2000; 103: 387-398Abstract Full Text Full Text PDF PubMed Scopus (345) Google Scholar, 3Siomos M.F. Badrinath A. Pasierbek P. Livingstone D. White J. Glotzer M. Nasmyth K. Separase is required for chromosome segregation during meiosis I in Caenorhabditis elegans.Curr. Biol. 2001; 11: 1825-1835Abstract Full Text Full Text PDF PubMed Scopus (117) Google Scholar]. We present evidence that Drosophila oocytes require sister-chromatid cohesion to maintain a physical attachment between recombinant chromosomes. Using FISH to monitor cohesion directly, we confirm that oocytes lacking ORD activity exhibit cohesion defects, consistent with previous genetic results [4Bickel S.E. Wyman D.W. Orr-Weaver T.L. Mutational analysis of the Drosophila sister-chromatid cohesion protein ORD and its role in the maintenance of centromeric cohesion.Genetics. 1997; 146: 1319-1331PubMed Google Scholar]. We also show that ordnull oocytes that have undergone recombination are unable to arrest at metaphase I, indicating that chiasmata are unstable in the absence of cohesion. Our results support the model that arm cohesion provides a conserved mechanism that ensures physical attachment between recombinant homologs until anaphase I." @default.
• W2004555667 created "2016-06-24" @default.
• W2004555667 creator A5013361235 @default.
• W2004555667 creator A5034360567 @default.
• W2004555667 creator A5048232622 @default.
• W2004555667 date "2002-06-01" @default.
• W2004555667 modified "2023-09-25" @default.
• W2004555667 title "The Sister-Chromatid Cohesion Protein ORD Is Required for Chiasma Maintenance in Drosophila Oocytes" @default.
• W2004555667 cites W1768695868 @default.
• W2004555667 cites W1808886550 @default.
• W2004555667 cites W1894751046 @default.
• W2004555667 cites W1970850296 @default.
• W2004555667 cites W1971801697 @default.
• W2004555667 cites W2011636754 @default.
• W2004555667 cites W2049127221 @default.
• W2004555667 cites W2052091966 @default.
• W2004555667 cites W2070030443 @default.
• W2004555667 cites W2080351280 @default.
• W2004555667 cites W2116776594 @default.
• W2004555667 cites W2119308964 @default.
• W2004555667 cites W2129494790 @default.
• W2004555667 cites W2162800954 @default.
• W2004555667 cites W2168712916 @default.
• W2004555667 doi "https://doi.org/10.1016/s0960-9822(02)00846-1" @default.
• W2004555667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12062057" @default.
• W2004555667 hasPublicationYear "2002" @default.
• W2004555667 type Work @default.
• W2004555667 sameAs 2004555667 @default.
• W2004555667 citedByCount "51" @default.
• W2004555667 countsByYear W20045556672013 @default.
• W2004555667 countsByYear W20045556672014 @default.
• W2004555667 countsByYear W20045556672015 @default.
• W2004555667 countsByYear W20045556672016 @default.
• W2004555667 countsByYear W20045556672017 @default.
• W2004555667 countsByYear W20045556672018 @default.
• W2004555667 countsByYear W20045556672019 @default.
• W2004555667 crossrefType "journal-article" @default.
• W2004555667 hasAuthorship W2004555667A5013361235 @default.
• W2004555667 hasAuthorship W2004555667A5034360567 @default.
• W2004555667 hasAuthorship W2004555667A5048232622 @default.
• W2004555667 hasBestOaLocation W20045556671 @default.
• W2004555667 hasConcept C102744134 @default.
• W2004555667 hasConcept C104317684 @default.
• W2004555667 hasConcept C115821613 @default.
• W2004555667 hasConcept C125832826 @default.
• W2004555667 hasConcept C148196450 @default.
• W2004555667 hasConcept C1491633281 @default.
• W2004555667 hasConcept C152369539 @default.
• W2004555667 hasConcept C192838845 @default.
• W2004555667 hasConcept C2778354886 @default.
• W2004555667 hasConcept C30481170 @default.
• W2004555667 hasConcept C47432576 @default.
• W2004555667 hasConcept C53420372 @default.
• W2004555667 hasConcept C54355233 @default.
• W2004555667 hasConcept C552990157 @default.
• W2004555667 hasConcept C64894306 @default.
• W2004555667 hasConcept C73397532 @default.
• W2004555667 hasConcept C8502773 @default.
• W2004555667 hasConcept C85813293 @default.
• W2004555667 hasConcept C86803240 @default.
• W2004555667 hasConcept C95444343 @default.
• W2004555667 hasConceptScore W2004555667C102744134 @default.
• W2004555667 hasConceptScore W2004555667C104317684 @default.
• W2004555667 hasConceptScore W2004555667C115821613 @default.
• W2004555667 hasConceptScore W2004555667C125832826 @default.
• W2004555667 hasConceptScore W2004555667C148196450 @default.
• W2004555667 hasConceptScore W2004555667C1491633281 @default.
• W2004555667 hasConceptScore W2004555667C152369539 @default.
• W2004555667 hasConceptScore W2004555667C192838845 @default.
• W2004555667 hasConceptScore W2004555667C2778354886 @default.
• W2004555667 hasConceptScore W2004555667C30481170 @default.
• W2004555667 hasConceptScore W2004555667C47432576 @default.
• W2004555667 hasConceptScore W2004555667C53420372 @default.
• W2004555667 hasConceptScore W2004555667C54355233 @default.
• W2004555667 hasConceptScore W2004555667C552990157 @default.
• W2004555667 hasConceptScore W2004555667C64894306 @default.
• W2004555667 hasConceptScore W2004555667C73397532 @default.
• W2004555667 hasConceptScore W2004555667C8502773 @default.
• W2004555667 hasConceptScore W2004555667C85813293 @default.
• W2004555667 hasConceptScore W2004555667C86803240 @default.
• W2004555667 hasConceptScore W2004555667C95444343 @default.
• W2004555667 hasIssue "11" @default.
• W2004555667 hasLocation W20045556671 @default.
• W2004555667 hasOpenAccess W2004555667 @default.
• W2004555667 hasPrimaryLocation W20045556671 @default.
• W2004555667 hasRelatedWork W1509135035 @default.
• W2004555667 hasRelatedWork W1971801697 @default.
• W2004555667 hasRelatedWork W2004555667 @default.
• W2004555667 hasRelatedWork W2016791473 @default.
• W2004555667 hasRelatedWork W2076836192 @default.
• W2004555667 hasRelatedWork W2086575042 @default.
• W2004555667 hasRelatedWork W2116318452 @default.
• W2004555667 hasRelatedWork W2118690717 @default.
• W2004555667 hasRelatedWork W2118776026 @default.
• W2004555667 hasRelatedWork W2153793802 @default.
• W2004555667 hasVolume "12" @default.
• W2004555667 isParatext "false" @default.
• W2004555667 isRetracted "false" @default.

• next