FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004568504> ?p ?o ?g. }

• W2004568504 endingPage "128" @default.
• W2004568504 startingPage "123" @default.
• W2004568504 abstract "Extending the scope of isotope mapping models becomes increasingly important in order to analyze strains and drive improved product yields as more complex pathways are engineered into strains and as secondary metabolites are used as starting points for new products. Here we present how the elementary metabolite unit (EMU) framework and flux coupling significantly decrease the computational burden of metabolic flux analysis (MFA) when applied to large-scale metabolic models. We applied these techniques to a previously published isotope mapping model of Escherichia coli accounting for 238 reactions. We find that the combined use of EMU and flux coupling analysis leads to a ten-fold decrease in the number of variables in comparison to the original isotope distribution vector (IDV) version of the model. In addition, using OptMeas the task of identifying additional measurement choices to fully specify the flows in the metabolic network required only 2% of the computation time of the one using IDVs. The observed computational savings reveal the rapid progress in performing MFA with increasingly larger isotope models with the ultimate goal of handling genome-scale models of metabolism." @default.
• W2004568504 created "2016-06-24" @default.
• W2004568504 creator A5025847732 @default.
• W2004568504 creator A5041035704 @default.
• W2004568504 creator A5068368439 @default.
• W2004568504 date "2010-03-01" @default.
• W2004568504 modified "2023-09-23" @default.
• W2004568504 title "Improved computational performance of MFA using elementary metabolite units and flux coupling" @default.
• W2004568504 cites W1723714747 @default.
• W2004568504 cites W1995820735 @default.
• W2004568504 cites W2014323212 @default.
• W2004568504 cites W2022012525 @default.
• W2004568504 cites W2023617120 @default.
• W2004568504 cites W2059902696 @default.
• W2004568504 cites W2092493462 @default.
• W2004568504 cites W2096245011 @default.
• W2004568504 cites W2096767559 @default.
• W2004568504 cites W2135476401 @default.
• W2004568504 cites W2138520475 @default.
• W2004568504 cites W2148497594 @default.
• W2004568504 cites W2157149907 @default.
• W2004568504 doi "https://doi.org/10.1016/j.ymben.2009.10.002" @default.
• W2004568504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19837183" @default.
• W2004568504 hasPublicationYear "2010" @default.
• W2004568504 type Work @default.
• W2004568504 sameAs 2004568504 @default.
• W2004568504 citedByCount "31" @default.
• W2004568504 countsByYear W20045685042012 @default.
• W2004568504 countsByYear W20045685042013 @default.
• W2004568504 countsByYear W20045685042014 @default.
• W2004568504 countsByYear W20045685042015 @default.
• W2004568504 countsByYear W20045685042017 @default.
• W2004568504 crossrefType "journal-article" @default.
• W2004568504 hasAuthorship W2004568504A5025847732 @default.
• W2004568504 hasAuthorship W2004568504A5041035704 @default.
• W2004568504 hasAuthorship W2004568504A5068368439 @default.
• W2004568504 hasConcept C101810790 @default.
• W2004568504 hasConcept C11413529 @default.
• W2004568504 hasConcept C121332964 @default.
• W2004568504 hasConcept C127413603 @default.
• W2004568504 hasConcept C131584629 @default.
• W2004568504 hasConcept C160941953 @default.
• W2004568504 hasConcept C164304813 @default.
• W2004568504 hasConcept C178790620 @default.
• W2004568504 hasConcept C181199279 @default.
• W2004568504 hasConcept C183696295 @default.
• W2004568504 hasConcept C185592680 @default.
• W2004568504 hasConcept C186060115 @default.
• W2004568504 hasConcept C2777477808 @default.
• W2004568504 hasConcept C2778755073 @default.
• W2004568504 hasConcept C41008148 @default.
• W2004568504 hasConcept C45374587 @default.
• W2004568504 hasConcept C55493867 @default.
• W2004568504 hasConcept C62231903 @default.
• W2004568504 hasConcept C62520636 @default.
• W2004568504 hasConcept C6350086 @default.
• W2004568504 hasConcept C68709404 @default.
• W2004568504 hasConcept C70721500 @default.
• W2004568504 hasConcept C78519656 @default.
• W2004568504 hasConcept C86803240 @default.
• W2004568504 hasConceptScore W2004568504C101810790 @default.
• W2004568504 hasConceptScore W2004568504C11413529 @default.
• W2004568504 hasConceptScore W2004568504C121332964 @default.
• W2004568504 hasConceptScore W2004568504C127413603 @default.
• W2004568504 hasConceptScore W2004568504C131584629 @default.
• W2004568504 hasConceptScore W2004568504C160941953 @default.
• W2004568504 hasConceptScore W2004568504C164304813 @default.
• W2004568504 hasConceptScore W2004568504C178790620 @default.
• W2004568504 hasConceptScore W2004568504C181199279 @default.
• W2004568504 hasConceptScore W2004568504C183696295 @default.
• W2004568504 hasConceptScore W2004568504C185592680 @default.
• W2004568504 hasConceptScore W2004568504C186060115 @default.
• W2004568504 hasConceptScore W2004568504C2777477808 @default.
• W2004568504 hasConceptScore W2004568504C2778755073 @default.
• W2004568504 hasConceptScore W2004568504C41008148 @default.
• W2004568504 hasConceptScore W2004568504C45374587 @default.
• W2004568504 hasConceptScore W2004568504C55493867 @default.
• W2004568504 hasConceptScore W2004568504C62231903 @default.
• W2004568504 hasConceptScore W2004568504C62520636 @default.
• W2004568504 hasConceptScore W2004568504C6350086 @default.
• W2004568504 hasConceptScore W2004568504C68709404 @default.
• W2004568504 hasConceptScore W2004568504C70721500 @default.
• W2004568504 hasConceptScore W2004568504C78519656 @default.
• W2004568504 hasConceptScore W2004568504C86803240 @default.
• W2004568504 hasIssue "2" @default.
• W2004568504 hasLocation W20045685041 @default.
• W2004568504 hasLocation W20045685042 @default.
• W2004568504 hasOpenAccess W2004568504 @default.
• W2004568504 hasPrimaryLocation W20045685041 @default.
• W2004568504 hasRelatedWork W1579192815 @default.
• W2004568504 hasRelatedWork W1865302071 @default.
• W2004568504 hasRelatedWork W1984004049 @default.
• W2004568504 hasRelatedWork W1999612141 @default.
• W2004568504 hasRelatedWork W2022041790 @default.
• W2004568504 hasRelatedWork W2024297267 @default.
• W2004568504 hasRelatedWork W2081052511 @default.
• W2004568504 hasRelatedWork W2332593186 @default.
• W2004568504 hasRelatedWork W2521105713 @default.

• next