FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004578327> ?p ?o ?g. }

• W2004578327 endingPage "238" @default.
• W2004578327 startingPage "230" @default.
• W2004578327 abstract "With maritime transport of crude oil from Alaska to California, there is significant potential for a catastrophic spill which could impact migrating salmon. Therefore, this study compared the lethal and sublethal metabolic actions of the water-accommodated fraction (WAF) and the chemically enhanced WAF (CEWAF, via Corexit 9500) of Prudhoe Bay crude oil in smolts of Chinook salmon (Onchorhyncus tshawytscha). After 96-h exposure to the CEWAF, the resulting LC50 was some 20 times higher (i.e., less toxic) than that of the WAF. Muscle and liver samples from surviving fish were collected and low-molecular weight metabolites were analyzed using one-dimensional 1H and projections of two-dimensional 1H J-resolved NMR. Principal component analysis (PCA), employed to analyze NMR spectra and identify most variance from the samples, revealed age-related metabolic changes in the fish within the replicated studies, but few consistent metabolic effects from the treatments. However, ANOVA results demonstrated that the dose–response metabolite patterns are both metabolite- and organ-dependent. In general, exposure to either WAF or CEWAF resulted in an increase of amino acids (i.e., valine, glutamine and glutamate) and a decrease of both organic osmolytes (i.e., glycerophosphorylcholine) and energetic substrates (i.e., succinate). The simultaneous increase of formate and decrease of glycerophosphorylcholine in the liver, or the decrease of glycerophosphorylcholine in muscle, may serve as sensitive sublethal biomarkers for WAF or CEWAF exposures, respectively. In conclusion, dispersant treatment significantly decreased the lethal potency of crude oil to salmon smolts, and the NMR-based metabolomics approach provided a sensitive means to characterize the sublethal metabolic actions." @default.
• W2004578327 created "2016-06-24" @default.
• W2004578327 creator A5001775222 @default.
• W2004578327 creator A5004705862 @default.
• W2004578327 creator A5016103128 @default.
• W2004578327 creator A5029635947 @default.
• W2004578327 creator A5030315985 @default.
• W2004578327 creator A5035762489 @default.
• W2004578327 creator A5042154436 @default.
• W2004578327 creator A5044020364 @default.
• W2004578327 creator A5055611974 @default.
• W2004578327 creator A5056747606 @default.
• W2004578327 creator A5063995469 @default.
• W2004578327 creator A5084135449 @default.
• W2004578327 creator A5088069892 @default.
• W2004578327 creator A5088254212 @default.
• W2004578327 creator A5090698453 @default.
• W2004578327 date "2009-11-01" @default.
• W2004578327 modified "2023-10-17" @default.
• W2004578327 title "Characterization of the metabolic actions of crude versus dispersed oil in salmon smolts via NMR-based metabolomics" @default.
• W2004578327 cites W1797956629 @default.
• W2004578327 cites W1963950524 @default.
• W2004578327 cites W1964287021 @default.
• W2004578327 cites W1965316721 @default.
• W2004578327 cites W1966959105 @default.
• W2004578327 cites W1982163654 @default.
• W2004578327 cites W1982853636 @default.
• W2004578327 cites W1989183098 @default.
• W2004578327 cites W1993554093 @default.
• W2004578327 cites W2003414488 @default.
• W2004578327 cites W2007185692 @default.
• W2004578327 cites W2008672509 @default.
• W2004578327 cites W2009787851 @default.
• W2004578327 cites W2024092685 @default.
• W2004578327 cites W2033090174 @default.
• W2004578327 cites W2037745876 @default.
• W2004578327 cites W2044599820 @default.
• W2004578327 cites W2044850827 @default.
• W2004578327 cites W2044974044 @default.
• W2004578327 cites W2056829614 @default.
• W2004578327 cites W2062117532 @default.
• W2004578327 cites W2064535527 @default.
• W2004578327 cites W2082313870 @default.
• W2004578327 cites W2101622685 @default.
• W2004578327 cites W2126532725 @default.
• W2004578327 cites W2133572636 @default.
• W2004578327 cites W2156009645 @default.
• W2004578327 cites W4249164705 @default.
• W2004578327 doi "https://doi.org/10.1016/j.aquatox.2009.09.006" @default.
• W2004578327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19850363" @default.
• W2004578327 hasPublicationYear "2009" @default.
• W2004578327 type Work @default.
• W2004578327 sameAs 2004578327 @default.
• W2004578327 citedByCount "47" @default.
• W2004578327 countsByYear W20045783272012 @default.
• W2004578327 countsByYear W20045783272013 @default.
• W2004578327 countsByYear W20045783272014 @default.
• W2004578327 countsByYear W20045783272015 @default.
• W2004578327 countsByYear W20045783272016 @default.
• W2004578327 countsByYear W20045783272017 @default.
• W2004578327 countsByYear W20045783272018 @default.
• W2004578327 countsByYear W20045783272019 @default.
• W2004578327 countsByYear W20045783272020 @default.
• W2004578327 countsByYear W20045783272021 @default.
• W2004578327 countsByYear W20045783272022 @default.
• W2004578327 crossrefType "journal-article" @default.
• W2004578327 hasAuthorship W2004578327A5001775222 @default.
• W2004578327 hasAuthorship W2004578327A5004705862 @default.
• W2004578327 hasAuthorship W2004578327A5016103128 @default.
• W2004578327 hasAuthorship W2004578327A5029635947 @default.
• W2004578327 hasAuthorship W2004578327A5030315985 @default.
• W2004578327 hasAuthorship W2004578327A5035762489 @default.
• W2004578327 hasAuthorship W2004578327A5042154436 @default.
• W2004578327 hasAuthorship W2004578327A5044020364 @default.
• W2004578327 hasAuthorship W2004578327A5055611974 @default.
• W2004578327 hasAuthorship W2004578327A5056747606 @default.
• W2004578327 hasAuthorship W2004578327A5063995469 @default.
• W2004578327 hasAuthorship W2004578327A5084135449 @default.
• W2004578327 hasAuthorship W2004578327A5088069892 @default.
• W2004578327 hasAuthorship W2004578327A5088254212 @default.
• W2004578327 hasAuthorship W2004578327A5090698453 @default.
• W2004578327 hasConcept C100206155 @default.
• W2004578327 hasConcept C127160389 @default.
• W2004578327 hasConcept C185592680 @default.
• W2004578327 hasConcept C192989942 @default.
• W2004578327 hasConcept C21565614 @default.
• W2004578327 hasConcept C2777477808 @default.
• W2004578327 hasConcept C2779349466 @default.
• W2004578327 hasConcept C2781123555 @default.
• W2004578327 hasConcept C28859421 @default.
• W2004578327 hasConcept C43617362 @default.
• W2004578327 hasConcept C515207424 @default.
• W2004578327 hasConcept C55493867 @default.
• W2004578327 hasConcept C62231903 @default.
• W2004578327 hasConcept C86803240 @default.
• W2004578327 hasConceptScore W2004578327C100206155 @default.
• W2004578327 hasConceptScore W2004578327C127160389 @default.
• W2004578327 hasConceptScore W2004578327C185592680 @default.

• next