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- W2004595433 endingPage "32" @default.
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- W2004595433 abstract "Mitochondria play a central role in cell fate after stressors such as ischemic brain injury. The convergence of intracellular signaling pathways on mitochondria and their release of critical factors are now recognized as a default conduit to cell death or survival. Besides the individual processes that converge on or emanate from mitochondria, a mitochondrial organellar response to changes in the cellular environment has recently been described. Whereas mitochondria have previously been perceived as a major center for cellular signaling, one can postulate that the organelle's dynamics themselves affect cell survival. This brief perspective review puts forward the concept that disruptions in mitochondrial dynamics--biogenesis, clearance, and fission/fusion events--may underlie neural diseases and thus could be targeted as neuroprotective strategies in the context of ischemic injury. To do so, we present a general overview of the current understanding of mitochondrial dynamics and regulation. We then review emerging studies that correlate mitochondrial biogenesis, mitophagy, and fission/fusion events with neurologic disease and recovery. An overview of the system as it is currently understood is presented, and current assessment strategies and their limitations are discussed." @default.
- W2004595433 created "2016-06-24" @default.
- W2004595433 creator A5000540211 @default.
- W2004595433 creator A5002792067 @default.
- W2004595433 creator A5035723149 @default.
- W2004595433 creator A5082857859 @default.
- W2004595433 date "2012-10-24" @default.
- W2004595433 modified "2023-09-26" @default.
- W2004595433 title "The Dynamics of the Mitochondrial Organelle as a Potential Therapeutic Target" @default.
- W2004595433 cites W102256019 @default.
- W2004595433 cites W114710803 @default.
- W2004595433 cites W1501828178 @default.
- W2004595433 cites W1510443235 @default.
- W2004595433 cites W1778352924 @default.
- W2004595433 cites W1877873625 @default.
- W2004595433 cites W1968843321 @default.
- W2004595433 cites W1969853133 @default.
- W2004595433 cites W1973582205 @default.
- W2004595433 cites W1973966118 @default.
- W2004595433 cites W1975490469 @default.
- W2004595433 cites W1978423374 @default.
- W2004595433 cites W1982520634 @default.
- W2004595433 cites W1987190216 @default.
- W2004595433 cites W1987732936 @default.
- W2004595433 cites W1990367769 @default.
- W2004595433 cites W1993490757 @default.
- W2004595433 cites W1994367478 @default.
- W2004595433 cites W1997797926 @default.
- W2004595433 cites W1999532278 @default.
- W2004595433 cites W1999701501 @default.
- W2004595433 cites W2004038082 @default.
- W2004595433 cites W2004968462 @default.
- W2004595433 cites W2005942480 @default.
- W2004595433 cites W2008584420 @default.
- W2004595433 cites W2009190773 @default.
- W2004595433 cites W2014253236 @default.
- W2004595433 cites W2019488837 @default.
- W2004595433 cites W2021180372 @default.
- W2004595433 cites W2021259285 @default.
- W2004595433 cites W2022279971 @default.
- W2004595433 cites W2025664869 @default.
- W2004595433 cites W2027482010 @default.
- W2004595433 cites W2033402078 @default.
- W2004595433 cites W2034657763 @default.
- W2004595433 cites W2036871097 @default.
- W2004595433 cites W2037703797 @default.
- W2004595433 cites W2038834667 @default.
- W2004595433 cites W2040643662 @default.
- W2004595433 cites W2040942018 @default.
- W2004595433 cites W2041255615 @default.
- W2004595433 cites W2041359223 @default.
- W2004595433 cites W2043217844 @default.
- W2004595433 cites W2044308920 @default.
- W2004595433 cites W2045821670 @default.
- W2004595433 cites W2046587261 @default.
- W2004595433 cites W2047242847 @default.
- W2004595433 cites W2050686598 @default.
- W2004595433 cites W2052248930 @default.
- W2004595433 cites W2055820092 @default.
- W2004595433 cites W2057147625 @default.
- W2004595433 cites W2058674237 @default.
- W2004595433 cites W2058768220 @default.
- W2004595433 cites W2059277863 @default.
- W2004595433 cites W2062867488 @default.
- W2004595433 cites W2063127941 @default.
- W2004595433 cites W2065717459 @default.
- W2004595433 cites W2066795714 @default.
- W2004595433 cites W2067554187 @default.
- W2004595433 cites W2067587647 @default.
- W2004595433 cites W2068988368 @default.
- W2004595433 cites W2071337010 @default.
- W2004595433 cites W2072164808 @default.
- W2004595433 cites W2072554243 @default.
- W2004595433 cites W2075058886 @default.
- W2004595433 cites W2075689062 @default.
- W2004595433 cites W2078575160 @default.
- W2004595433 cites W2079457709 @default.
- W2004595433 cites W2080421381 @default.
- W2004595433 cites W2082340869 @default.
- W2004595433 cites W2087020729 @default.
- W2004595433 cites W2091706208 @default.
- W2004595433 cites W2092680571 @default.
- W2004595433 cites W2093558980 @default.
- W2004595433 cites W2097107638 @default.
- W2004595433 cites W2099880591 @default.
- W2004595433 cites W2100300726 @default.
- W2004595433 cites W2100894616 @default.
- W2004595433 cites W2101661839 @default.
- W2004595433 cites W2104382960 @default.
- W2004595433 cites W2107189849 @default.
- W2004595433 cites W2107847140 @default.
- W2004595433 cites W2115524420 @default.
- W2004595433 cites W2121760835 @default.
- W2004595433 cites W2123720975 @default.
- W2004595433 cites W2124872060 @default.
- W2004595433 cites W2125221913 @default.
- W2004595433 cites W2126272143 @default.
- W2004595433 cites W2126409180 @default.