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• W2004604828 abstract "Prebiotics, probiotics and synbiotics are dietary ingredients with the potential to influence health and mucosal and systemic immune function by altering the composition of the gut microbiota. In the present study, a candidate prebiotic (xylo-oligosaccharide, XOS, 8 g/d), probiotic ( Bifidobacterium animalis subsp. lactis Bi-07, 10 9 colony-forming units (CFU)/d) or synbiotic (8 g XOS+10 9 CFU Bi-07/d) was given to healthy adults (25–65 years) for 21 d. The aim was to identify the effect of the supplements on bowel habits, self-reported mood, composition of the gut microbiota, blood lipid concentrations and immune function. XOS supplementation increased mean bowel movements per d ( P = 0·009), but did not alter the symptoms of bloating, abdominal pain or flatulence or the incidence of any reported adverse events compared with maltodextrin supplementation. XOS supplementation significantly increased participant-reported vitality ( P = 0·003) and happiness ( P = 0·034). Lowest reported use of analgesics was observed during the XOS+Bi-07 supplementation period ( P = 0·004). XOS supplementation significantly increased faecal bifidobacterial counts ( P = 0·008) and fasting plasma HDL concentrations ( P = 0·005). Bi-07 supplementation significantly increased faecal B. lactis content ( P = 0·007), lowered lipopolysaccharide-stimulated IL-4 secretion in whole-blood cultures ( P = 0·035) and salivary IgA content ( P = 0·040) and increased IL-6 secretion ( P = 0·009). XOS supplementation resulted in lower expression of CD16/56 on natural killer T cells ( P = 0·027) and lower IL-10 secretion ( P = 0·049), while XOS and Bi-07 supplementation reduced the expression of CD19 on B cells (XOS × Bi-07, P = 0·009). The present study demonstrates that XOS induce bifidogenesis, improve aspects of the plasma lipid profile and modulate the markers of immune function in healthy adults. The provision of XOS+Bi-07 as a synbiotic may confer further benefits due to the discrete effects of Bi-07 on the gut microbiota and markers of immune function." @default.
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• W2004604828 date "2014-03-24" @default.
• W2004604828 modified "2023-10-16" @default.
• W2004604828 title "Xylo-oligosaccharides alone or in synbiotic combination with <i>Bifidobacterium animalis</i> subsp. <i>lactis</i> induce bifidogenesis and modulate markers of immune function in healthy adults: a double-blind, placebo-controlled, randomised, factorial cross-over study" @default.
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• W2004604828 doi "https://doi.org/10.1017/s0007114513004261" @default.
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