Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004604872> ?p ?o ?g. }
- W2004604872 endingPage "516" @default.
- W2004604872 startingPage "507" @default.
- W2004604872 abstract "Iron accumulates as a function of age in several tissues in vivo and is associated with the pathology of numerous age-related diseases. The molecular basis of this change may be due to a loss of iron homeostasis at the cellular level. Therefore, changes in iron content in primary human fibroblast cells (IMR-90) were studied in vitro as a model of cellular senescence. Total iron content increased exponentially during cellular senescence, resulting in 10-fold higher levels of iron compared with young cells. Low-dose hydrogen peroxide (H2O2) induced early senescence in IMR-90s and concomitantly accelerated iron accumulation. Furthermore, senescence-related and H2O2-stimulated iron accumulation was attenuated by N-tert-butylhydroxylamine (NtBHA), a mitochondrial antioxidant that delays senescence in vitro. However, SV40-transformed, immortalized IMR-90s showed no time-dependent changes in metal content in culture or when treated with H2O2 and/or NtBHA. These data indicate that iron accumulation occurs during normal cellular senescence in vitro. This accumulation of iron may contribute to the increased oxidative stress and cellular dysfunction seen in senescent cells." @default.
- W2004604872 created "2016-06-24" @default.
- W2004604872 creator A5004879671 @default.
- W2004604872 creator A5013840188 @default.
- W2004604872 creator A5047067531 @default.
- W2004604872 creator A5080578598 @default.
- W2004604872 date "2003-10-01" @default.
- W2004604872 modified "2023-10-01" @default.
- W2004604872 title "Iron Accumulation During Cellular Senescence in Human Fibroblasts<i>In Vitro</i>" @default.
- W2004604872 cites W1523325879 @default.
- W2004604872 cites W1553161361 @default.
- W2004604872 cites W1605406862 @default.
- W2004604872 cites W1775613062 @default.
- W2004604872 cites W1973212066 @default.
- W2004604872 cites W1973723400 @default.
- W2004604872 cites W1978027075 @default.
- W2004604872 cites W1978472797 @default.
- W2004604872 cites W1978775178 @default.
- W2004604872 cites W1978972221 @default.
- W2004604872 cites W1980718206 @default.
- W2004604872 cites W1981835221 @default.
- W2004604872 cites W1988478272 @default.
- W2004604872 cites W2003141949 @default.
- W2004604872 cites W2005244641 @default.
- W2004604872 cites W2013253264 @default.
- W2004604872 cites W2018080238 @default.
- W2004604872 cites W2018938097 @default.
- W2004604872 cites W2019276195 @default.
- W2004604872 cites W2022206726 @default.
- W2004604872 cites W2025595360 @default.
- W2004604872 cites W2025875333 @default.
- W2004604872 cites W2029309071 @default.
- W2004604872 cites W2032535354 @default.
- W2004604872 cites W2032807278 @default.
- W2004604872 cites W2039517040 @default.
- W2004604872 cites W2042202360 @default.
- W2004604872 cites W2042255954 @default.
- W2004604872 cites W2047906602 @default.
- W2004604872 cites W2055261567 @default.
- W2004604872 cites W2056014680 @default.
- W2004604872 cites W2063554678 @default.
- W2004604872 cites W2065303599 @default.
- W2004604872 cites W2066226784 @default.
- W2004604872 cites W2069849662 @default.
- W2004604872 cites W2070079507 @default.
- W2004604872 cites W2079887405 @default.
- W2004604872 cites W2084674106 @default.
- W2004604872 cites W2091375706 @default.
- W2004604872 cites W2108517583 @default.
- W2004604872 cites W2112587738 @default.
- W2004604872 cites W2113007696 @default.
- W2004604872 cites W2114505460 @default.
- W2004604872 cites W2116001892 @default.
- W2004604872 cites W2152102707 @default.
- W2004604872 cites W2155506096 @default.
- W2004604872 cites W2164902408 @default.
- W2004604872 cites W220834664 @default.
- W2004604872 cites W2417138217 @default.
- W2004604872 cites W83831086 @default.
- W2004604872 doi "https://doi.org/10.1089/152308603770310158" @default.
- W2004604872 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4503765" @default.
- W2004604872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14580305" @default.
- W2004604872 hasPublicationYear "2003" @default.
- W2004604872 type Work @default.
- W2004604872 sameAs 2004604872 @default.
- W2004604872 citedByCount "67" @default.
- W2004604872 countsByYear W20046048722012 @default.
- W2004604872 countsByYear W20046048722013 @default.
- W2004604872 countsByYear W20046048722015 @default.
- W2004604872 countsByYear W20046048722016 @default.
- W2004604872 countsByYear W20046048722017 @default.
- W2004604872 countsByYear W20046048722018 @default.
- W2004604872 countsByYear W20046048722019 @default.
- W2004604872 countsByYear W20046048722020 @default.
- W2004604872 countsByYear W20046048722021 @default.
- W2004604872 countsByYear W20046048722022 @default.
- W2004604872 countsByYear W20046048722023 @default.
- W2004604872 crossrefType "journal-article" @default.
- W2004604872 hasAuthorship W2004604872A5004879671 @default.
- W2004604872 hasAuthorship W2004604872A5013840188 @default.
- W2004604872 hasAuthorship W2004604872A5047067531 @default.
- W2004604872 hasAuthorship W2004604872A5080578598 @default.
- W2004604872 hasBestOaLocation W20046048722 @default.
- W2004604872 hasConcept C185592680 @default.
- W2004604872 hasConcept C202751555 @default.
- W2004604872 hasConcept C207001950 @default.
- W2004604872 hasConcept C2776151105 @default.
- W2004604872 hasConcept C500499127 @default.
- W2004604872 hasConcept C522857546 @default.
- W2004604872 hasConcept C54355233 @default.
- W2004604872 hasConcept C55493867 @default.
- W2004604872 hasConcept C86803240 @default.
- W2004604872 hasConcept C95444343 @default.
- W2004604872 hasConceptScore W2004604872C185592680 @default.
- W2004604872 hasConceptScore W2004604872C202751555 @default.
- W2004604872 hasConceptScore W2004604872C207001950 @default.
- W2004604872 hasConceptScore W2004604872C2776151105 @default.
- W2004604872 hasConceptScore W2004604872C500499127 @default.