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- W2004605636 abstract "Almost 100% of APL patients carry chimeric transcripts encoding truncated RARα fused to homo-oligomerization domains from partner proteins. To gain further insights into the cellular transformation mechanisms mediated by RARα fusion proteins, thorough structure/function analyses have been performed and identified the POZ homo-oligomerization domain as the minimal transformation domain that is necessary and sufficient for PLZF-RARα-mediated in vitro transformation of primary hematopoietic cells. A transformation-incompetent PLZF-RARα mutant defective in homo-oligomerization but not corepressor interaction could be rescued by synthetic FKBP-oligomerization domains. Furthermore, an artificial FKBP-RARα construct not only mimicked various biochemical properties of bona fide RARα fusion proteins but also mediated an ATRA-dependent transformation. Taken together, these findings endorse an oligomerization-dependent mechanism for RARα-mediated transformation and suggest a potential avenue for molecular therapy." @default.
- W2004605636 created "2016-06-24" @default.
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- W2004605636 date "2006-02-01" @default.
- W2004605636 modified "2023-09-25" @default.
- W2004605636 title "Forced homo-oligomerization of RARα leads to transformation of primary hematopoietic cells" @default.
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- W2004605636 doi "https://doi.org/10.1016/j.ccr.2006.01.005" @default.
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