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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004607375> ?p ?o ?g. }

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• W2004607375 abstract "We previously determined the co-crystal structure of the zinc finger region of transcription factor YY1 (YY1Delta) bound to the initiator element (Inr) of the adenoassociated virus (AAV) P5 gene promoter [Houbaviy, H.B. et al. (1996) Proc. Natl. Acad. Sci. USA 93, 13577-13582]. Our structure explained both binding specificity and the ability of YY1 to support specific, unidirectional transcription initiation.To further understand Inr recognition by YY1, we analyzed the YY1Delta-Inr interaction by isothermal titration calorimetry (ITC) and used limited proteolysis, DNase I footprinting and missing nucleoside experiments to show that YY1Delta and full-length YY1 (YY1WT) have indistinguishable DNA binding properties.YY1 binding occurs at an equilibrium dissociation constant (K(d)) of about 1 microM, and exhibits a large negative heat capacity change (DeltaC(p)). We analyzed the thermodynamic behavior of YY1Delta in terms of buried solvent-accessible surface area resulting from interaction of two rigid bodies, which could not explain our measured value of DeltaC(p). We must, therefore, postulate conformational changes in YY1 and/or the Inr or question the validity of current DeltaC(p) analysis methods for protein-DNA interactions." @default.
• W2004607375 created "2016-06-24" @default.
• W2004607375 creator A5068648875 @default.
• W2004607375 creator A5085479143 @default.
• W2004607375 date "2001-02-01" @default.
• W2004607375 modified "2023-10-07" @default.
• W2004607375 title "Thermodynamic analysis of the interaction between YY1 and the AAV P5 promoter initiator element" @default.
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• W2004607375 doi "https://doi.org/10.1016/s1074-5521(00)90066-8" @default.
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