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- W2004610365 abstract "This editorial refers to ‘Nerves projecting from the intrinsic cardiac ganglia of the pulmonary veins modulate sinoatrial node pacemaker function’ by M. Zarzoso et al ., pp. 566–575, this issue. The role of the autonomic nervous system (ANS) in the genesis of atrial arrhythmias has been extensively studied in the past,1,2 with both the parasympathetic and the sympathetic nervous system having been implicated in the genesis of atrial fibrillation (AF).3,4 The discovery over a decade ago of the role of the pulmonary veins (PVs) in the genesis of AF has generated renewed interest in understanding the autonomic profile of the atria, in order to understand the role of the ANS in the genesis of focal triggers in the PVs. Clinical and animal data suggest that these PV trigger and drivers appear to be at least partially modulated by the ANS,4–6 with different studies implicating either the sympathetic or the parasympathetic nervous system in the genesis and/or maintenance of focal AF. More recent studies postulate a dominant role for the parasympathetic nervous system (in focal AF), in part on account of the vagal or Bezold–Jarisch-like reflexes (e.g. sinus bradycardia, asystole, AV block, or hypotension) noted during radiofrequency ablation of the PV tissues in patients with paroxysmal focal AF.7 Indeed, some clinical studies have suggested that the attenuation of these …" @default.
- W2004610365 created "2016-06-24" @default.
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- W2004610365 date "2013-06-28" @default.
- W2004610365 modified "2023-10-03" @default.
- W2004610365 title "How the pulmonary veins 'talk' to the sinoatrial node: new insights into an old mystery" @default.
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- W2004610365 doi "https://doi.org/10.1093/cvr/cvt175" @default.
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