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• W2004615284 abstract "A population of cells showing the surface phenotype of Langerhans cells (LCs) was identified in the dermal infiltrates of cutaneous T cell lymphoma (CTCL). Peroxidase-conjugated OKT6, a monoclonal antibody reactive with epidermal LCs, was used to directly label frozen tissue sections of diseased skin from twenty-three patients with CTCL, two patients with secondary cutaneous involvement by a B cell lymphoma, and three patients with lymphocytoma cutis. OKT6-reactive cells represented a significant although minor population in the dermal infiltrate of twenty-two of the twenty-three CTCL biopsies, accounting for up to 5% of the cells. Double-labeling studies revealed that the OKT6-positive cells also exhibited Ia but not T cell antigens. Since OKT6-reactive cells were not found in either the B cell lymphomas or lymphocytorna cutis, their presence in a malignant infiltrate is suggestive of a T cell neoplasm. A population of cells showing the surface phenotype of Langerhans cells (LCs) was identified in the dermal infiltrates of cutaneous T cell lymphoma (CTCL). Peroxidase-conjugated OKT6, a monoclonal antibody reactive with epidermal LCs, was used to directly label frozen tissue sections of diseased skin from twenty-three patients with CTCL, two patients with secondary cutaneous involvement by a B cell lymphoma, and three patients with lymphocytoma cutis. OKT6-reactive cells represented a significant although minor population in the dermal infiltrate of twenty-two of the twenty-three CTCL biopsies, accounting for up to 5% of the cells. Double-labeling studies revealed that the OKT6-positive cells also exhibited Ia but not T cell antigens. Since OKT6-reactive cells were not found in either the B cell lymphomas or lymphocytorna cutis, their presence in a malignant infiltrate is suggestive of a T cell neoplasm." @default.
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• W2004615284 date "1982-03-01" @default.
• W2004615284 modified "2023-09-23" @default.
• W2004615284 title "In situ identification of Langerhans cells in the dermal infiltrate of cutaneous T cell lymphoma" @default.
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• W2004615284 doi "https://doi.org/10.1016/s0190-9622(82)70028-3" @default.
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