FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004618640> ?p ?o ?g. }

• W2004618640 abstract "Convection enhanced delivery is an attractive option for the treatment of several neurodegenerative diseases such as Parkinson, Alzheimer, and brain tumors. However, the occurrence of a backflow is a major problem impeding the widespread use of this technique. In this paper, we analyze experimentally the force impact of high flow microinfusion on the deformable gel matrix. To investigate these fluid structure interactions, two optical methods are reported. First, gel stresses during microinfusion were visualized through a linear polariscope. Second, the displacement field was tracked using 400 nm nanobeads as space markers. The corresponding strain and porosity fields were calculated from the experimental observations. Finally, experimental data were used to validate a computational model for fluid flow and deformation in soft porous media. Our studies demonstrate experimentally, the distribution and magnitude of stress and displacement fields near the catheter tip. The effect of fluid traction on porosity and hydraulic conductivity is analyzed. The increase in fluid content in the catheter vicinity enhances the gel hydraulic conductivity. Our computational model takes into account the changes in porosity and hydraulic conductivity. The simulations agree with experimental findings. The experiments quantified solid matrix deformation, due to fluid infusion. Maximum deformations occur in areas of relatively large fluid velocities leading to volumetric strain of the matrix, causing changes in hydraulic conductivity and porosity close to the catheter tip. The gradual expansion of this region with increased porosity leads to decreased hydraulic resistance that may also create an alternative pathway for fluid flow." @default.
• W2004618640 created "2016-06-24" @default.
• W2004618640 creator A5005804267 @default.
• W2004618640 creator A5014429141 @default.
• W2004618640 creator A5039536239 @default.
• W2004618640 date "2010-03-29" @default.
• W2004618640 modified "2023-09-25" @default.
• W2004618640 title "Experimental Techniques for Studying Poroelasticity in Brain Phantom Gels Under High Flow Microinfusion" @default.
• W2004618640 cites W1987614008 @default.
• W2004618640 cites W2011879200 @default.
• W2004618640 cites W2042975893 @default.
• W2004618640 cites W2043168409 @default.
• W2004618640 cites W2049024822 @default.
• W2004618640 cites W2050624061 @default.
• W2004618640 cites W2055919556 @default.
• W2004618640 cites W2056730157 @default.
• W2004618640 cites W2097492471 @default.
• W2004618640 cites W2105060883 @default.
• W2004618640 cites W2128121680 @default.
• W2004618640 cites W2135062838 @default.
• W2004618640 cites W2135573573 @default.
• W2004618640 cites W2151153669 @default.
• W2004618640 cites W2164522304 @default.
• W2004618640 cites W2181569653 @default.
• W2004618640 cites W621370381 @default.
• W2004618640 doi "https://doi.org/10.1115/1.4001164" @default.
• W2004618640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20459209" @default.
• W2004618640 hasPublicationYear "2010" @default.
• W2004618640 type Work @default.
• W2004618640 sameAs 2004618640 @default.
• W2004618640 citedByCount "28" @default.
• W2004618640 countsByYear W20046186402012 @default.
• W2004618640 countsByYear W20046186402013 @default.
• W2004618640 countsByYear W20046186402014 @default.
• W2004618640 countsByYear W20046186402015 @default.
• W2004618640 countsByYear W20046186402016 @default.
• W2004618640 countsByYear W20046186402017 @default.
• W2004618640 countsByYear W20046186402018 @default.
• W2004618640 countsByYear W20046186402019 @default.
• W2004618640 countsByYear W20046186402021 @default.
• W2004618640 countsByYear W20046186402022 @default.
• W2004618640 countsByYear W20046186402023 @default.
• W2004618640 crossrefType "journal-article" @default.
• W2004618640 hasAuthorship W2004618640A5005804267 @default.
• W2004618640 hasAuthorship W2004618640A5014429141 @default.
• W2004618640 hasAuthorship W2004618640A5039536239 @default.
• W2004618640 hasConcept C105569014 @default.
• W2004618640 hasConcept C106487976 @default.
• W2004618640 hasConcept C107551265 @default.
• W2004618640 hasConcept C121332964 @default.
• W2004618640 hasConcept C127313418 @default.
• W2004618640 hasConcept C131540310 @default.
• W2004618640 hasConcept C147789679 @default.
• W2004618640 hasConcept C15744967 @default.
• W2004618640 hasConcept C159390177 @default.
• W2004618640 hasConcept C159750122 @default.
• W2004618640 hasConcept C159985019 @default.
• W2004618640 hasConcept C181965411 @default.
• W2004618640 hasConcept C185592680 @default.
• W2004618640 hasConcept C187320778 @default.
• W2004618640 hasConcept C192562407 @default.
• W2004618640 hasConcept C542102704 @default.
• W2004618640 hasConcept C57879066 @default.
• W2004618640 hasConcept C63184880 @default.
• W2004618640 hasConcept C6648577 @default.
• W2004618640 hasConcept C90278072 @default.
• W2004618640 hasConceptScore W2004618640C105569014 @default.
• W2004618640 hasConceptScore W2004618640C106487976 @default.
• W2004618640 hasConceptScore W2004618640C107551265 @default.
• W2004618640 hasConceptScore W2004618640C121332964 @default.
• W2004618640 hasConceptScore W2004618640C127313418 @default.
• W2004618640 hasConceptScore W2004618640C131540310 @default.
• W2004618640 hasConceptScore W2004618640C147789679 @default.
• W2004618640 hasConceptScore W2004618640C15744967 @default.
• W2004618640 hasConceptScore W2004618640C159390177 @default.
• W2004618640 hasConceptScore W2004618640C159750122 @default.
• W2004618640 hasConceptScore W2004618640C159985019 @default.
• W2004618640 hasConceptScore W2004618640C181965411 @default.
• W2004618640 hasConceptScore W2004618640C185592680 @default.
• W2004618640 hasConceptScore W2004618640C187320778 @default.
• W2004618640 hasConceptScore W2004618640C192562407 @default.
• W2004618640 hasConceptScore W2004618640C542102704 @default.
• W2004618640 hasConceptScore W2004618640C57879066 @default.
• W2004618640 hasConceptScore W2004618640C63184880 @default.
• W2004618640 hasConceptScore W2004618640C6648577 @default.
• W2004618640 hasConceptScore W2004618640C90278072 @default.
• W2004618640 hasIssue "5" @default.
• W2004618640 hasLocation W20046186401 @default.
• W2004618640 hasLocation W20046186402 @default.
• W2004618640 hasOpenAccess W2004618640 @default.
• W2004618640 hasPrimaryLocation W20046186401 @default.
• W2004618640 hasRelatedWork W1996262908 @default.
• W2004618640 hasRelatedWork W2020906566 @default.
• W2004618640 hasRelatedWork W2042220204 @default.
• W2004618640 hasRelatedWork W2602011382 @default.
• W2004618640 hasRelatedWork W3127253354 @default.
• W2004618640 hasRelatedWork W3141962193 @default.
• W2004618640 hasRelatedWork W3199424891 @default.
• W2004618640 hasRelatedWork W3200810235 @default.
• W2004618640 hasRelatedWork W3209011335 @default.

• next