Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004633130> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2004633130 endingPage "436" @default.
- W2004633130 startingPage "427" @default.
- W2004633130 abstract "N-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]bicyclo-[2.2.1]heptane-2,3-di-exo-carboxyimide dihydrogen citrate (tandospirone), a novel anxiolytic agent, was labeled with carbon-14 individually at the imido carbonyl group and the pyrimidinyl ring. The synthesis of carbonyl-labeled tandospirone was achieved according to the scheme shown in Fig. 3. Diels-Alder reaction of maleic anhydride (2) with cyclopentadiene (3) afforded the endo anhydride (4), which was transformed into the imide (5) by treating with ammonia water. Thermal isomerization of the endo imide (5) and subsequent chromatographic separation gave the pure exo compound (6). Catalytic hydrogenation of 6 followed by alkylation with 1,4-dibromobutane (8) yielded the bromide (9a). Condensation of 9a with N-(2-pyrimidinyl)piperazine (10a) followed by treatment of the resulting disubstituted piperazine (11a) with citric acid afforded [carbonyl-14C]tandospirone (1a). The overall yield of 1a was 22% from 2. The similar method was applied to the synthesis of pyrimidinyl-labeled tandospirone as shown in Fig. 4. Condensation of 2-chloro[2-14C]pyrimidine (12) with anhydrous piperazine gave the pyrimidinylpiperazine (10b). N-alkylation of 10b followed by treatment with citric acid afforded [pyrimidinyl-2-14C]tandospirone (1b). The overall yield of 1b was 68% from 12." @default.
- W2004633130 created "2016-06-24" @default.
- W2004633130 creator A5043715211 @default.
- W2004633130 creator A5072800531 @default.
- W2004633130 date "1992-06-01" @default.
- W2004633130 modified "2023-09-27" @default.
- W2004633130 title "14C-labeling of a novel anxiolytic agent tandospirone" @default.
- W2004633130 cites W1963705135 @default.
- W2004633130 cites W2315598322 @default.
- W2004633130 cites W2335731174 @default.
- W2004633130 cites W3098623621 @default.
- W2004633130 cites W3104813414 @default.
- W2004633130 doi "https://doi.org/10.1002/jlcr.2580310602" @default.
- W2004633130 hasPublicationYear "1992" @default.
- W2004633130 type Work @default.
- W2004633130 sameAs 2004633130 @default.
- W2004633130 citedByCount "2" @default.
- W2004633130 countsByYear W20046331302023 @default.
- W2004633130 crossrefType "journal-article" @default.
- W2004633130 hasAuthorship W2004633130A5043715211 @default.
- W2004633130 hasAuthorship W2004633130A5072800531 @default.
- W2004633130 hasConcept C134121241 @default.
- W2004633130 hasConcept C155647269 @default.
- W2004633130 hasConcept C15920480 @default.
- W2004633130 hasConcept C161790260 @default.
- W2004633130 hasConcept C164361826 @default.
- W2004633130 hasConcept C178790620 @default.
- W2004633130 hasConcept C185592680 @default.
- W2004633130 hasConcept C191897082 @default.
- W2004633130 hasConcept C192562407 @default.
- W2004633130 hasConcept C24961977 @default.
- W2004633130 hasConcept C2776201271 @default.
- W2004633130 hasConcept C2776300020 @default.
- W2004633130 hasConcept C2777604212 @default.
- W2004633130 hasConcept C2777666793 @default.
- W2004633130 hasConcept C2778176622 @default.
- W2004633130 hasConcept C521977710 @default.
- W2004633130 hasConceptScore W2004633130C134121241 @default.
- W2004633130 hasConceptScore W2004633130C155647269 @default.
- W2004633130 hasConceptScore W2004633130C15920480 @default.
- W2004633130 hasConceptScore W2004633130C161790260 @default.
- W2004633130 hasConceptScore W2004633130C164361826 @default.
- W2004633130 hasConceptScore W2004633130C178790620 @default.
- W2004633130 hasConceptScore W2004633130C185592680 @default.
- W2004633130 hasConceptScore W2004633130C191897082 @default.
- W2004633130 hasConceptScore W2004633130C192562407 @default.
- W2004633130 hasConceptScore W2004633130C24961977 @default.
- W2004633130 hasConceptScore W2004633130C2776201271 @default.
- W2004633130 hasConceptScore W2004633130C2776300020 @default.
- W2004633130 hasConceptScore W2004633130C2777604212 @default.
- W2004633130 hasConceptScore W2004633130C2777666793 @default.
- W2004633130 hasConceptScore W2004633130C2778176622 @default.
- W2004633130 hasConceptScore W2004633130C521977710 @default.
- W2004633130 hasIssue "6" @default.
- W2004633130 hasLocation W20046331301 @default.
- W2004633130 hasOpenAccess W2004633130 @default.
- W2004633130 hasPrimaryLocation W20046331301 @default.
- W2004633130 hasRelatedWork W1987163918 @default.
- W2004633130 hasRelatedWork W1988060195 @default.
- W2004633130 hasRelatedWork W2019919093 @default.
- W2004633130 hasRelatedWork W2029589532 @default.
- W2004633130 hasRelatedWork W2047888616 @default.
- W2004633130 hasRelatedWork W2097014657 @default.
- W2004633130 hasRelatedWork W2139412160 @default.
- W2004633130 hasRelatedWork W2368387811 @default.
- W2004633130 hasRelatedWork W2952508841 @default.
- W2004633130 hasRelatedWork W857048760 @default.
- W2004633130 hasVolume "31" @default.
- W2004633130 isParatext "false" @default.
- W2004633130 isRetracted "false" @default.
- W2004633130 magId "2004633130" @default.
- W2004633130 workType "article" @default.