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- W2004636360 abstract "Subjects with Mild Cognitive Impairment (MCI) have cognitive and spatial navigation (SN) impairment. Individuals without cognitive function or SN impairment yet reporting subjective memory complaints (SMC) are at higher risk of MCI or dementia. Subjects with depression or anxiety report SMC more frequently than those without depression or anxiety. Both, subjects with MCI and SMC suffer more frequently from depression and/or anxiety than their healthy peers. We investigated whether 1.) Depression or anxiety influences subjective perception of SN in SMC and in MCI 2.) Self-reported daily-life SN difficulties reflect the real-space navigation performance. A total of 76 subjects including patients with amnestic (aMCI; n=29), nonamnestic (naMCI; n=23) MCI and SMC (n=24) underwent real-space navigation testing in the human analogue of the Morris Water Maze (hMWM). A multiple choice 15 item subjective SN complaints (SSNC) questionnaire assessing SN performance in one's daily life was administered. Depression and anxiety was assessed by Geriatric Depression Scale (GDS) and Beck Anxiety Inventory (BAI) together with neuropsychological battery. Mann-Whitney U test was used. There were no differences in GDS and BAI scores among aMCI, naMCI, and SMC subjects. MCI groups together did not report more SN complaints than SMC group regardless of differences in the real-space navigation performance between these two groups. However, when all subjects were divided according to their median BAI score (≤10) to anxious vs. non-anxious groups, there was a difference in total SSNC score (p=0.037), specifically in items “worse orientation outside the neighborhood” (p<0.001) and “asking for directions in supermarkets” (p<0.001), which was more pronounced in the MCI group (p=0.09). This effect was not observed in groups divided by GDS median (≤4) to depressive and non-depressive. The anxious and depressive groups did not differ in real-space navigation performance in hMWM. Anxiety but not depression seems to influence subjective perception of SN abilities in SMC and MCI subjects, regardless of their real-space navigation performance. These results suggest that a screening question on anxiety and not only on depression might be useful in assessing patients with memory difficulties; future research should assess whether therapy of anxiety might improve their everyday functioning." @default.
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- W2004636360 date "2013-07-01" @default.
- W2004636360 modified "2023-10-16" @default.
- W2004636360 title "P4-233: Anxiety but not depression affects self-reported spatial navigation difficulties irrespective of the real-space navigation performance in individuals at risk of Alzheimer's disease" @default.
- W2004636360 doi "https://doi.org/10.1016/j.jalz.2013.05.1625" @default.
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