FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004641756> ?p ?o ?g. }

• W2004641756 endingPage "e83974" @default.
• W2004641756 startingPage "e83974" @default.
• W2004641756 abstract "Melanopsin-expressing retinal ganglion cells (mRGCs) in the eye play an important role in many light-activated non-image-forming functions including neonatal photoaversion and the adult pupillary light reflex (PLR). MRGCs rely on glutamate and possibly PACAP (pituitary adenylate cyclase-activating polypeptide) to relay visual signals to the brain. However, the role of these neurotransmitters for individual non-image-forming responses remains poorly understood. To clarify the role of glutamatergic signaling from mRGCs in neonatal aversion to light and in adult PLR, we conditionally deleted vesicular glutamate transporter (VGLUT2) selectively from mRGCs in mice. We found that deletion of VGLUT2 in mRGCs abolished negative phototaxis and light-induced distress vocalizations in neonatal mice, underscoring a necessary role for glutamatergic signaling. In adult mice, loss of VGLUT2 in mRGCs resulted in a slow and an incomplete PLR. We conclude that glutamatergic neurotransmission from mRGCs is required for neonatal photoaversion but is complemented by another non-glutamatergic signaling mechanism for the pupillary light reflex in adult mice. We speculate that this complementary signaling might be due to PACAP neurotransmission from mRGCs." @default.
• W2004641756 created "2016-06-24" @default.
• W2004641756 creator A5013611528 @default.
• W2004641756 creator A5021299820 @default.
• W2004641756 creator A5027616900 @default.
• W2004641756 creator A5030830335 @default.
• W2004641756 creator A5057435242 @default.
• W2004641756 creator A5087333571 @default.
• W2004641756 creator A5087390751 @default.
• W2004641756 date "2013-12-31" @default.
• W2004641756 modified "2023-09-30" @default.
• W2004641756 title "Glutamatergic Neurotransmission from Melanopsin Retinal Ganglion Cells Is Required for Neonatal Photoaversion but Not Adult Pupillary Light Reflex" @default.
• W2004641756 cites W1965034230 @default.
• W2004641756 cites W1968042048 @default.
• W2004641756 cites W1983647741 @default.
• W2004641756 cites W1986596083 @default.
• W2004641756 cites W1987079191 @default.
• W2004641756 cites W2009527263 @default.
• W2004641756 cites W2015786747 @default.
• W2004641756 cites W2025860612 @default.
• W2004641756 cites W2026111092 @default.
• W2004641756 cites W2027846728 @default.
• W2004641756 cites W2036239753 @default.
• W2004641756 cites W2037500812 @default.
• W2004641756 cites W2042768174 @default.
• W2004641756 cites W2045102202 @default.
• W2004641756 cites W2050123488 @default.
• W2004641756 cites W2051724192 @default.
• W2004641756 cites W2062411733 @default.
• W2004641756 cites W2069342665 @default.
• W2004641756 cites W2070113127 @default.
• W2004641756 cites W2072164586 @default.
• W2004641756 cites W2073748624 @default.
• W2004641756 cites W2075158314 @default.
• W2004641756 cites W2134036551 @default.
• W2004641756 cites W2134583314 @default.
• W2004641756 cites W2155377690 @default.
• W2004641756 doi "https://doi.org/10.1371/journal.pone.0083974" @default.
• W2004641756 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3877098" @default.
• W2004641756 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24391855" @default.
• W2004641756 hasPublicationYear "2013" @default.
• W2004641756 type Work @default.
• W2004641756 sameAs 2004641756 @default.
• W2004641756 citedByCount "19" @default.
• W2004641756 countsByYear W20046417562014 @default.
• W2004641756 countsByYear W20046417562015 @default.
• W2004641756 countsByYear W20046417562016 @default.
• W2004641756 countsByYear W20046417562018 @default.
• W2004641756 countsByYear W20046417562019 @default.
• W2004641756 countsByYear W20046417562020 @default.
• W2004641756 countsByYear W20046417562021 @default.
• W2004641756 countsByYear W20046417562022 @default.
• W2004641756 countsByYear W20046417562023 @default.
• W2004641756 crossrefType "journal-article" @default.
• W2004641756 hasAuthorship W2004641756A5013611528 @default.
• W2004641756 hasAuthorship W2004641756A5021299820 @default.
• W2004641756 hasAuthorship W2004641756A5027616900 @default.
• W2004641756 hasAuthorship W2004641756A5030830335 @default.
• W2004641756 hasAuthorship W2004641756A5057435242 @default.
• W2004641756 hasAuthorship W2004641756A5087333571 @default.
• W2004641756 hasAuthorship W2004641756A5087390751 @default.
• W2004641756 hasBestOaLocation W20046417561 @default.
• W2004641756 hasConcept C169760540 @default.
• W2004641756 hasConcept C170493617 @default.
• W2004641756 hasConcept C189780591 @default.
• W2004641756 hasConcept C200170125 @default.
• W2004641756 hasConcept C2777093970 @default.
• W2004641756 hasConcept C2777394604 @default.
• W2004641756 hasConcept C2777624874 @default.
• W2004641756 hasConcept C2780648746 @default.
• W2004641756 hasConcept C2781184276 @default.
• W2004641756 hasConcept C3449773 @default.
• W2004641756 hasConcept C38137364 @default.
• W2004641756 hasConcept C55493867 @default.
• W2004641756 hasConcept C61174792 @default.
• W2004641756 hasConcept C83974742 @default.
• W2004641756 hasConcept C86803240 @default.
• W2004641756 hasConceptScore W2004641756C169760540 @default.
• W2004641756 hasConceptScore W2004641756C170493617 @default.
• W2004641756 hasConceptScore W2004641756C189780591 @default.
• W2004641756 hasConceptScore W2004641756C200170125 @default.
• W2004641756 hasConceptScore W2004641756C2777093970 @default.
• W2004641756 hasConceptScore W2004641756C2777394604 @default.
• W2004641756 hasConceptScore W2004641756C2777624874 @default.
• W2004641756 hasConceptScore W2004641756C2780648746 @default.
• W2004641756 hasConceptScore W2004641756C2781184276 @default.
• W2004641756 hasConceptScore W2004641756C3449773 @default.
• W2004641756 hasConceptScore W2004641756C38137364 @default.
• W2004641756 hasConceptScore W2004641756C55493867 @default.
• W2004641756 hasConceptScore W2004641756C61174792 @default.
• W2004641756 hasConceptScore W2004641756C83974742 @default.
• W2004641756 hasConceptScore W2004641756C86803240 @default.
• W2004641756 hasIssue "12" @default.
• W2004641756 hasLocation W20046417561 @default.
• W2004641756 hasLocation W20046417562 @default.
• W2004641756 hasLocation W20046417563 @default.
• W2004641756 hasLocation W20046417564 @default.
• W2004641756 hasLocation W20046417565 @default.

• next