FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004642783> ?p ?o ?g. }

• W2004642783 abstract "This paper is a tribute to Paul Lohman at the occasion of his retirement from the position of Professor in the Medical Faculty at the Leiden University in The Netherlands and as Director of its Department of Radiation Genetics and Chemical Mutagenesis. Paul's contributions to the science of genetic toxicology are discussed in the context of more recent insights as to how mammalian cells process DNA damage, and how this may lead to cancer and, possibly, aging. Starting with his work on the characterization of UV-induced DNA repair in cultured cells from xeroderma pigmentosum patients and the development of methodology for monitoring the removal of UV-induced lesions in human cells, the concept of the key lesion is introduced. Among the myriad of DNA lesions that can be induced in DNA as a consequence of exposure to a range of natural or synthetic mutagens, key lesions are the ones responsible for subsequent adverse effects, for example, because they give rise to mutation. The development of methods using immunofluorescence microscopy to detect and identify such key lesions and quantitate them at the single cell level, is one of the highlights of Paul's career. Based on the perceived need to evaluate mutational end points in vivo in relation to specific lesions identified by his immunofluorescence methods, Paul subsequently made crucial contributions to the development of the first transgenic mouse model to measure mutations in chromosomally integrated reporter genes. In parallel to his experimental work, Paul greatly contributed to genetic toxicology at the theoretical level by his work on the development and evaluation of methods for assessment or prediction of risks of exposure to environmental mutagens. Finally, Paul has served the discipline of genetic toxicology in a more administrative role in various ways, both locally as one of the founders of the Medical Genetics Center South-West Netherlands and internationally by playing a prominent role in organizations such as ICPEMC. Here, his numerous contributions to the journal Mutation Research, both as author on many papers and as Executive Managing Editor should not go unmentioned." @default.
• W2004642783 created "2016-06-24" @default.
• W2004642783 creator A5012398734 @default.
• W2004642783 date "2002-02-01" @default.
• W2004642783 modified "2023-09-30" @default.
• W2004642783 title "On key lesions and all that: a tribute to Paul Lohman" @default.
• W2004642783 cites W130725917 @default.
• W2004642783 cites W1490937614 @default.
• W2004642783 cites W1565890429 @default.
• W2004642783 cites W1658682427 @default.
• W2004642783 cites W1970285696 @default.
• W2004642783 cites W1973677817 @default.
• W2004642783 cites W1975817860 @default.
• W2004642783 cites W1976856900 @default.
• W2004642783 cites W1978432772 @default.
• W2004642783 cites W1984417778 @default.
• W2004642783 cites W1988795006 @default.
• W2004642783 cites W1989122623 @default.
• W2004642783 cites W1989971670 @default.
• W2004642783 cites W1999058777 @default.
• W2004642783 cites W2001595307 @default.
• W2004642783 cites W2004678494 @default.
• W2004642783 cites W2005289526 @default.
• W2004642783 cites W2008659241 @default.
• W2004642783 cites W2008828261 @default.
• W2004642783 cites W2011725341 @default.
• W2004642783 cites W2015147973 @default.
• W2004642783 cites W2017803853 @default.
• W2004642783 cites W2023270095 @default.
• W2004642783 cites W2023745448 @default.
• W2004642783 cites W2024982377 @default.
• W2004642783 cites W2033092772 @default.
• W2004642783 cites W2044287438 @default.
• W2004642783 cites W2046831727 @default.
• W2004642783 cites W2048664916 @default.
• W2004642783 cites W2049805294 @default.
• W2004642783 cites W2062646175 @default.
• W2004642783 cites W2062743398 @default.
• W2004642783 cites W2063269133 @default.
• W2004642783 cites W2063770747 @default.
• W2004642783 cites W2069647602 @default.
• W2004642783 cites W2070989503 @default.
• W2004642783 cites W2080152855 @default.
• W2004642783 cites W2083264187 @default.
• W2004642783 cites W2085382072 @default.
• W2004642783 cites W2086110031 @default.
• W2004642783 cites W2088159749 @default.
• W2004642783 cites W2088623580 @default.
• W2004642783 cites W2093508542 @default.
• W2004642783 cites W2096136751 @default.
• W2004642783 cites W2098772291 @default.
• W2004642783 cites W2113724086 @default.
• W2004642783 cites W2117178083 @default.
• W2004642783 cites W2118406573 @default.
• W2004642783 cites W2123852626 @default.
• W2004642783 cites W2130867391 @default.
• W2004642783 cites W2135947850 @default.
• W2004642783 cites W2145102206 @default.
• W2004642783 cites W2170970288 @default.
• W2004642783 cites W2319228790 @default.
• W2004642783 cites W4235228584 @default.
• W2004642783 doi "https://doi.org/10.1016/s0027-5107(01)00302-5" @default.
• W2004642783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11827705" @default.
• W2004642783 hasPublicationYear "2002" @default.
• W2004642783 type Work @default.
• W2004642783 sameAs 2004642783 @default.
• W2004642783 citedByCount "0" @default.
• W2004642783 crossrefType "journal-article" @default.
• W2004642783 hasAuthorship W2004642783A5012398734 @default.
• W2004642783 hasConcept C104317684 @default.
• W2004642783 hasConcept C134935766 @default.
• W2004642783 hasConcept C143425029 @default.
• W2004642783 hasConcept C151730666 @default.
• W2004642783 hasConcept C159654299 @default.
• W2004642783 hasConcept C16318435 @default.
• W2004642783 hasConcept C2777038452 @default.
• W2004642783 hasConcept C2778236600 @default.
• W2004642783 hasConcept C2778378917 @default.
• W2004642783 hasConcept C2779343474 @default.
• W2004642783 hasConcept C501734568 @default.
• W2004642783 hasConcept C52119013 @default.
• W2004642783 hasConcept C54355233 @default.
• W2004642783 hasConcept C552990157 @default.
• W2004642783 hasConcept C86803240 @default.
• W2004642783 hasConcept C95457728 @default.
• W2004642783 hasConceptScore W2004642783C104317684 @default.
• W2004642783 hasConceptScore W2004642783C134935766 @default.
• W2004642783 hasConceptScore W2004642783C143425029 @default.
• W2004642783 hasConceptScore W2004642783C151730666 @default.
• W2004642783 hasConceptScore W2004642783C159654299 @default.
• W2004642783 hasConceptScore W2004642783C16318435 @default.
• W2004642783 hasConceptScore W2004642783C2777038452 @default.
• W2004642783 hasConceptScore W2004642783C2778236600 @default.
• W2004642783 hasConceptScore W2004642783C2778378917 @default.
• W2004642783 hasConceptScore W2004642783C2779343474 @default.
• W2004642783 hasConceptScore W2004642783C501734568 @default.
• W2004642783 hasConceptScore W2004642783C52119013 @default.
• W2004642783 hasConceptScore W2004642783C54355233 @default.
• W2004642783 hasConceptScore W2004642783C552990157 @default.
• W2004642783 hasConceptScore W2004642783C86803240 @default.

• next