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• W2004643785 abstract "Placental function in early pregnancy reportedly is associated with a risk of low birth weight. This study was planned to learn whether fetal growth in the first trimester is associated with the duration of pregnancy, birth weight, and/or the risk of having a small for gestational age (SGA) infant. Among more than 38,000 women taking part in a prospective multicenter study in the years 1999–2003 were 976 who conceived by assisted reproductive technology, had crown-rump length measured by ultrasound in the first trimester, and delivered a live singleton infant with no evidence of congenital or chromosomal abnormality. The difference between actual and predicted crown-rump length or the difference in days of gestation (ΔGA) was the postconceptional age as estimated by crown-rump length minus the actual days since conception. Birth weight varied linearly with ΔGA; a 1-day increase in ΔGA correlated with a 28-g increase in birth weight. Adjusting for maternal characteristics and pregnancy complications did not significantly alter this association, but it was significantly attenuated by adjusting for duration of pregnancy. The duration of pregnancy also was proportional to ΔGA; a 1-day increase in ΔGA was associated with a 0.4-day increase in duration. Again, neither maternal features nor pregnancy complications significantly altered this association. The ΔGA explained about 2% of variation in birth weight. The rate of SGA infants was 11.5%. The risk varied inversely with fetal growth in the first trimester; a 1-day increase in ΔGA was associated with a 13% reduction in risk. Adjusting for maternal characteristics and pregnancy complications did not significantly alter the likelihood of delivering a SGA infant. Gestational age at the time of ultrasonography did not significantly influence either the association between ΔGA and birth weight or the risk of having a SGA infant. These findings show that fetal size in the first trimester of pregnancy is associated with birth weight. They add to growing evidence that conditions in very early pregnancy ultimately influence the duration of pregnancy and the risk of late-pregnancy complications." @default.
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• W2004643785 date "2007-10-01" @default.
• W2004643785 modified "2023-10-18" @default.
• W2004643785 title "Fetal Growth in Early Pregnancy and Risk of Delivering Low Birth Weight Infant: Prospective Cohort Study" @default.
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• W2004643785 doi "https://doi.org/10.1097/01.ogx.0000281559.90480.b0" @default.
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