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• W2004646572 abstract "Introduction To evaluate the “natural history” of idiopathic restless legs syndrome (iRLS) by means of a structured questionnaire with 17 questions. Materials and methods One hundred and fifty (150) patients with iRLS attending the Sleep Disorders Center of the San Raffaele hospital of Milan were consecutively enrolled. Eighty-four (56%) women, 66 (44%) men, age: 60.3  ±  14.38, age at onset 44.5  ±  17.66, IRLS 23.9  ±  6.42, PLMI 41.0  ±  48.21, ESS 6.7  ±  4.66, ferritin level 98.5 ± 121.14. Secondary forms of RLS were excluded on the basis of clinical history data and neurologic examination. Results Twenty-one % of patients reported RLS age onset between 46–55 years, 19% between 36–45 years and 15% between 26–35 years. No family history for RLS in 45% of this sample was recorded, while 42% of patients reported a parent with RLS. Twenty-three % of RLS patients had never had any problems with sleep, while 21% had had sleep problems in the past 10 years. Among patients who had had sleep disturbances before the onset of RLS (57%), 85% suffered from insomnia. Thirty-seven % of subjects reported symptoms of RLS to be “sporadic” at onset, 30% “fluctuating”, and 15% “intermittent”. At onset, 46% of subjects reported the severity of RLS symptoms to be ”mild”. The frequency of symptoms at onset was reported to be ⩽ 1/week in 65% of patients, 2–3/week in 23%, and more than 3 times/week in 12% of patients. In 73% of patients symptoms tended to worsen over time and only in 19% they were stable. In 29% of patients, approximately 3–5 years occurred between RLS onset and diagnosis/treatment. In 73% of subjects therapy remained stable. Thirty-five % of subjects took only 1 drug for RLS treatment, 29% 2 drugs, ⩾ 3 drugs were used by 22% of patients. At the time of this study, 69% of subjects reported RLS symptoms more than 3 times/week. The intensity of the symptoms was ”moderate” in 55% and ”severe” in 28%. Forty % of women had no pregnancies, 27% had one pregnancy and 29% had two pregnancies; 66% of women reported no variations on RLS symptoms during pregnancy, 10% a “mild” worsening, another 10% a “moderate” worsening while 6% complained a “severe” worsening. Conclusion Despite the availability of drugs believed to be effective in RLS and their regular use in the majority of patients the RLS symptoms tend to persist. This points to the need of the development of new and more effective therapeutic strategies. Acknowledgements We thanks RLS patients for their availability in detailing their sleep and ill history." @default.
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• W2004646572 date "2013-12-01" @default.
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• W2004646572 title "The natural history of restless legs syndrome: retrospective data on a clinical sample" @default.
• W2004646572 doi "https://doi.org/10.1016/j.sleep.2013.11.080" @default.
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