FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004646581> ?p ?o ?g. }

• W2004646581 endingPage "608" @default.
• W2004646581 startingPage "599" @default.
• W2004646581 abstract "The formation of reactive oxygen intermediates (ROI) during redox cycling of newly synthetized potential antitumor 2,5-bis (1-aziridinyl)-1,4-benzoquinone (BABQ) derivatives has been studied by assaying the production of ROI (superoxide, hydroxyl radical, and hydrogen peroxide) by xanthine oxidase in the presence of BABQ derivatives. At low concentrations (< μM) some BABQ derivatives turned out to inhibit the production of superoxide and hydroxyl radicals by xanthine oxidase, while the effect on the xanthine-oxidase-induced production of hydrogen peroxide was much less pronounced. Induction of DNA strand breaks by reactive oxygen species generated by xanthine oxidase was also inhibited by BABQ derivatives. The DNA damage was comparable to the amount of hydroxyl radicals produced. The inhibiting effect on hydroxyl radical production can be explained as a consequence of the lowered level of superoxidase, which disrupts the Haber-Weiss reaction sequence. The inhibitory effect of BABQ derivatives on superoxide formation correlated with their one-electron reduction potentials: BABQ derivatives with a high reduction potential scavenge superoxide anion radicals produced by xanthine oxidase, leading to reduced BABQ species and production of hydrogen peroxide from reoxidation of reduced BABQ. This study, using a unique series of BABQ derivatives with an extended range of reduction potentials, demonstrates that the formation of superoxide and hydroxyl radicals by bioreductively activated antitumor quinones can in principle be uncoupled from alkylating activity." @default.
• W2004646581 created "2016-06-24" @default.
• W2004646581 creator A5012851826 @default.
• W2004646581 creator A5015432436 @default.
• W2004646581 creator A5040753908 @default.
• W2004646581 creator A5045120040 @default.
• W2004646581 creator A5054594631 @default.
• W2004646581 creator A5069941279 @default.
• W2004646581 creator A5071591596 @default.
• W2004646581 creator A5076267073 @default.
• W2004646581 date "1992-12-01" @default.
• W2004646581 modified "2023-10-14" @default.
• W2004646581 title "Redox cycling of potential antitumor aziridinyl quinones" @default.
• W2004646581 cites W112949929 @default.
• W2004646581 cites W1513967973 @default.
• W2004646581 cites W1553328291 @default.
• W2004646581 cites W1809574325 @default.
• W2004646581 cites W1820406695 @default.
• W2004646581 cites W1879184430 @default.
• W2004646581 cites W1969887535 @default.
• W2004646581 cites W1972434884 @default.
• W2004646581 cites W1978455727 @default.
• W2004646581 cites W1979430318 @default.
• W2004646581 cites W1980022601 @default.
• W2004646581 cites W1985348295 @default.
• W2004646581 cites W1992437051 @default.
• W2004646581 cites W1996283445 @default.
• W2004646581 cites W2010304889 @default.
• W2004646581 cites W2011727704 @default.
• W2004646581 cites W2014300288 @default.
• W2004646581 cites W2021715591 @default.
• W2004646581 cites W2023286233 @default.
• W2004646581 cites W2027403336 @default.
• W2004646581 cites W2028585334 @default.
• W2004646581 cites W2054126792 @default.
• W2004646581 cites W2055829143 @default.
• W2004646581 cites W2057442686 @default.
• W2004646581 cites W2058000339 @default.
• W2004646581 cites W2060013516 @default.
• W2004646581 cites W2064179734 @default.
• W2004646581 cites W2071458498 @default.
• W2004646581 cites W2073345848 @default.
• W2004646581 cites W2076052186 @default.
• W2004646581 cites W2087058128 @default.
• W2004646581 cites W2090456031 @default.
• W2004646581 cites W2117476853 @default.
• W2004646581 cites W2130301472 @default.
• W2004646581 cites W2149855017 @default.
• W2004646581 cites W2165884308 @default.
• W2004646581 cites W2206183556 @default.
• W2004646581 cites W4234762889 @default.
• W2004646581 cites W62688098 @default.
• W2004646581 doi "https://doi.org/10.1016/0891-5849(92)90034-e" @default.
• W2004646581 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1334033" @default.
• W2004646581 hasPublicationYear "1992" @default.
• W2004646581 type Work @default.
• W2004646581 sameAs 2004646581 @default.
• W2004646581 citedByCount "11" @default.
• W2004646581 crossrefType "journal-article" @default.
• W2004646581 hasAuthorship W2004646581A5012851826 @default.
• W2004646581 hasAuthorship W2004646581A5015432436 @default.
• W2004646581 hasAuthorship W2004646581A5040753908 @default.
• W2004646581 hasAuthorship W2004646581A5045120040 @default.
• W2004646581 hasAuthorship W2004646581A5054594631 @default.
• W2004646581 hasAuthorship W2004646581A5069941279 @default.
• W2004646581 hasAuthorship W2004646581A5071591596 @default.
• W2004646581 hasAuthorship W2004646581A5076267073 @default.
• W2004646581 hasBestOaLocation W20046465812 @default.
• W2004646581 hasConcept C139066938 @default.
• W2004646581 hasConcept C178790620 @default.
• W2004646581 hasConcept C181199279 @default.
• W2004646581 hasConcept C185592680 @default.
• W2004646581 hasConcept C2776778087 @default.
• W2004646581 hasConcept C2778102346 @default.
• W2004646581 hasConcept C2779470414 @default.
• W2004646581 hasConcept C2780795997 @default.
• W2004646581 hasConcept C38485361 @default.
• W2004646581 hasConcept C48349386 @default.
• W2004646581 hasConcept C533411734 @default.
• W2004646581 hasConcept C55493867 @default.
• W2004646581 hasConcept C55904794 @default.
• W2004646581 hasConcept C75473681 @default.
• W2004646581 hasConceptScore W2004646581C139066938 @default.
• W2004646581 hasConceptScore W2004646581C178790620 @default.
• W2004646581 hasConceptScore W2004646581C181199279 @default.
• W2004646581 hasConceptScore W2004646581C185592680 @default.
• W2004646581 hasConceptScore W2004646581C2776778087 @default.
• W2004646581 hasConceptScore W2004646581C2778102346 @default.
• W2004646581 hasConceptScore W2004646581C2779470414 @default.
• W2004646581 hasConceptScore W2004646581C2780795997 @default.
• W2004646581 hasConceptScore W2004646581C38485361 @default.
• W2004646581 hasConceptScore W2004646581C48349386 @default.
• W2004646581 hasConceptScore W2004646581C533411734 @default.
• W2004646581 hasConceptScore W2004646581C55493867 @default.
• W2004646581 hasConceptScore W2004646581C55904794 @default.
• W2004646581 hasConceptScore W2004646581C75473681 @default.
• W2004646581 hasIssue "6" @default.
• W2004646581 hasLocation W20046465811 @default.

• next