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• W2004647712 abstract "A novel prophylactic regimen is demanded for preventing bladder cancer recurrence, because of the high side-effect tolls of conventional adjuvant Bacillus Calmette-Guérin (BCG) immunotherapy, in addition to its only moderate efficacy. In vitro and animal studies have demonstrated the anti-cancer properties of a medicinal mushroom called Ganoderma lucidum (GL). In this study, a pre-malignant human uroepithelial cells (HUC-PC) model was utilized to compare the effectiveness between ethanol extract of GL (GLe) and BCG on interleukin-6 (IL-6) secretion and lactate dehydrogenase (LDH) cytotoxicity. Additionally, parameters relevant to the BCG efficacy and safety, including free soluble fibronectin (FN) and cell-surface glycosaminoglycans (GAGs) levels were tested, following the exposure of GLe to the cells. GLe at 100 μg/ml and BCG at 4.8 × 107 CFU were shown to induce equivalent levels of IL-6, suggesting the potential synergism, while the tested concentrations of GLe were non-cytotoxic. During the initial four hours of GLe exposure, the free FN concentrations in harvested media were significantly reduced that might facilitate the binding of BCG for uroepithelial internalization to enhance BCG efficacy. Furthermore, the cell membrane-bound GAGs levels of HUC-PC cells were significant increased in response to GLe to suggest cellular protection from BCG infection. In summary, current findings suggest the potential additive synergism of GLe with the BCG efficacy, as well as its protective effects, and thus reducing the BCG toxicity." @default.
• W2004647712 created "2016-06-24" @default.
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• W2004647712 creator A5049812548 @default.
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• W2004647712 date "2013-01-01" @default.
• W2004647712 modified "2023-10-01" @default.
• W2004647712 title "The Effects of <i>Ganoderma lucidum</i> on Initial Events Related to the <i>Bacillus Calmette-Gu&#233;rin</i> Efficacy and Toxicity on High-Risk Uroepithelial Cells: An <i>in Vitro</i> Preliminary Study" @default.
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• W2004647712 doi "https://doi.org/10.4236/cm.2013.42009" @default.
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