Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004648421> ?p ?o ?g. }
- W2004648421 endingPage "14" @default.
- W2004648421 startingPage "1" @default.
- W2004648421 abstract "Peripheral neuropathies are heterogeneous disorders presenting often with hyperalgesia and allodynia. This study has assessed if chronic constriction injury (CCI) of sciatic nerve is accompanied by increased oxidative stress and central nervous system (CNS) changes and if these changes are sensitive to treatment with thioctic acid. Thioctic acid is a naturally occurring antioxidant existing in two optical isomers (+)- and (−)-thioctic acid and in the racemic form. It has been proposed for treating disorders associated with increased oxidative stress. Sciatic nerve CCI was made in spontaneously hypertensive rats (SHRs) and in normotensive reference cohorts. Rats were untreated or treated intraperitoneally for 14 days with (+/−)-, (+)-, or (−)-thioctic acid. Oxidative stress, astrogliosis, myelin sheets status, and neuronal injury in motor and sensory cerebrocortical areas were assessed. Increase of oxidative stress markers, astrogliosis, and neuronal damage accompanied by a decreased expression of neurofilament were observed in SHR. This phenomenon was more pronounced after CCI. Thioctic acid countered astrogliosis and neuronal damage, (+)-thioctic acid being more active than (+/−)- or (−)-enantiomers. These findings suggest a neuroprotective activity of thioctic acid on CNS lesions consequent to CCI and that the compound may represent a therapeutic option for entrapment neuropathies." @default.
- W2004648421 created "2016-06-24" @default.
- W2004648421 creator A5007869905 @default.
- W2004648421 creator A5013590235 @default.
- W2004648421 creator A5014325411 @default.
- W2004648421 creator A5017358008 @default.
- W2004648421 creator A5049261961 @default.
- W2004648421 creator A5053045013 @default.
- W2004648421 creator A5089810177 @default.
- W2004648421 date "2013-01-01" @default.
- W2004648421 modified "2023-10-02" @default.
- W2004648421 title "Neuroprotective Activity of Thioctic Acid in Central Nervous System Lesions Consequent to Peripheral Nerve Injury" @default.
- W2004648421 cites W1935855454 @default.
- W2004648421 cites W1965696818 @default.
- W2004648421 cites W1966351672 @default.
- W2004648421 cites W1969305530 @default.
- W2004648421 cites W1970008312 @default.
- W2004648421 cites W1977611114 @default.
- W2004648421 cites W1983013119 @default.
- W2004648421 cites W1992670283 @default.
- W2004648421 cites W1994536765 @default.
- W2004648421 cites W1997515903 @default.
- W2004648421 cites W2011426419 @default.
- W2004648421 cites W2013221973 @default.
- W2004648421 cites W2019021013 @default.
- W2004648421 cites W2026657037 @default.
- W2004648421 cites W2028043291 @default.
- W2004648421 cites W2032832927 @default.
- W2004648421 cites W2038148370 @default.
- W2004648421 cites W2049292692 @default.
- W2004648421 cites W2051727801 @default.
- W2004648421 cites W2056565769 @default.
- W2004648421 cites W2058020736 @default.
- W2004648421 cites W2066946504 @default.
- W2004648421 cites W2070081929 @default.
- W2004648421 cites W2070953518 @default.
- W2004648421 cites W2072579585 @default.
- W2004648421 cites W2073902046 @default.
- W2004648421 cites W2077864446 @default.
- W2004648421 cites W2079403841 @default.
- W2004648421 cites W2082267072 @default.
- W2004648421 cites W2084335181 @default.
- W2004648421 cites W2092601978 @default.
- W2004648421 cites W2095901107 @default.
- W2004648421 cites W2101182270 @default.
- W2004648421 cites W2101243709 @default.
- W2004648421 cites W2108536798 @default.
- W2004648421 cites W2112502671 @default.
- W2004648421 cites W2112690253 @default.
- W2004648421 cites W2130312501 @default.
- W2004648421 cites W2131165483 @default.
- W2004648421 cites W2131410124 @default.
- W2004648421 cites W2136230933 @default.
- W2004648421 cites W2139635582 @default.
- W2004648421 cites W2149608846 @default.
- W2004648421 cites W2156813826 @default.
- W2004648421 cites W2158843422 @default.
- W2004648421 cites W2167749443 @default.
- W2004648421 cites W4235885965 @default.
- W2004648421 doi "https://doi.org/10.1155/2013/985093" @default.
- W2004648421 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3914604" @default.
- W2004648421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24527432" @default.
- W2004648421 hasPublicationYear "2013" @default.
- W2004648421 type Work @default.
- W2004648421 sameAs 2004648421 @default.
- W2004648421 citedByCount "20" @default.
- W2004648421 countsByYear W20046484212014 @default.
- W2004648421 countsByYear W20046484212015 @default.
- W2004648421 countsByYear W20046484212016 @default.
- W2004648421 countsByYear W20046484212017 @default.
- W2004648421 countsByYear W20046484212018 @default.
- W2004648421 countsByYear W20046484212019 @default.
- W2004648421 countsByYear W20046484212020 @default.
- W2004648421 countsByYear W20046484212021 @default.
- W2004648421 countsByYear W20046484212022 @default.
- W2004648421 countsByYear W20046484212023 @default.
- W2004648421 crossrefType "journal-article" @default.
- W2004648421 hasAuthorship W2004648421A5007869905 @default.
- W2004648421 hasAuthorship W2004648421A5013590235 @default.
- W2004648421 hasAuthorship W2004648421A5014325411 @default.
- W2004648421 hasAuthorship W2004648421A5017358008 @default.
- W2004648421 hasAuthorship W2004648421A5049261961 @default.
- W2004648421 hasAuthorship W2004648421A5053045013 @default.
- W2004648421 hasAuthorship W2004648421A5089810177 @default.
- W2004648421 hasBestOaLocation W20046484211 @default.
- W2004648421 hasConcept C126322002 @default.
- W2004648421 hasConcept C185592680 @default.
- W2004648421 hasConcept C25498285 @default.
- W2004648421 hasConcept C2776151105 @default.
- W2004648421 hasConcept C2778004101 @default.
- W2004648421 hasConcept C2779491571 @default.
- W2004648421 hasConcept C2779965356 @default.
- W2004648421 hasConcept C2781149210 @default.
- W2004648421 hasConcept C2908636690 @default.
- W2004648421 hasConcept C42219234 @default.
- W2004648421 hasConcept C529278444 @default.
- W2004648421 hasConcept C55493867 @default.
- W2004648421 hasConcept C71924100 @default.