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- W2004648579 startingPage "79" @default.
- W2004648579 abstract "Protein inhalation is a delivery route which offers high potential for direct local lung application of proteins. Liquid formulations are usually available in early stages of biopharmaceutical development and nebulizers are the device of choice for atomization avoiding additional process steps like drying and enabling fast progression to clinical trials. While some proteins were proven to remain stable throughout aerosolization e.g. DNase, many biopharmaceuticals are more susceptible towards the stresses encountered during nebulization. The main reason for protein instability is unfolding and aggregation at the air-liquid interface, a problem which is of particular challenge in the case of ultrasound and jet nebulizers due to recirculation of much of the generated droplets. Surfactants are an important formulation component to protect the sensitive biomolecules. A second important challenge is warming of ultrasound and vibrating mesh devices, which can be overcome by overfilling, precooled solutions or cooling of the reservoir. Ultimately, formulation development has to go hand in hand with device evaluation." @default.
- W2004648579 created "2016-06-24" @default.
- W2004648579 creator A5016601141 @default.
- W2004648579 creator A5017684985 @default.
- W2004648579 creator A5027191616 @default.
- W2004648579 date "2015-10-01" @default.
- W2004648579 modified "2023-10-18" @default.
- W2004648579 title "Protein stability in pulmonary drug delivery via nebulization" @default.
- W2004648579 cites W100505031 @default.
- W2004648579 cites W129066762 @default.
- W2004648579 cites W140093203 @default.
- W2004648579 cites W1493274789 @default.
- W2004648579 cites W1551446381 @default.
- W2004648579 cites W1557288505 @default.
- W2004648579 cites W1565091296 @default.
- W2004648579 cites W1575908580 @default.
- W2004648579 cites W158602015 @default.
- W2004648579 cites W1700796997 @default.
- W2004648579 cites W1963657239 @default.
- W2004648579 cites W1963873137 @default.
- W2004648579 cites W1963925934 @default.
- W2004648579 cites W1964280098 @default.
- W2004648579 cites W1968956992 @default.
- W2004648579 cites W1969266865 @default.
- W2004648579 cites W1970276133 @default.
- W2004648579 cites W1970869438 @default.
- W2004648579 cites W1970898345 @default.
- W2004648579 cites W1976902210 @default.
- W2004648579 cites W1977197389 @default.
- W2004648579 cites W1978285198 @default.
- W2004648579 cites W1982052228 @default.
- W2004648579 cites W1982999905 @default.
- W2004648579 cites W1983387292 @default.
- W2004648579 cites W1985941856 @default.
- W2004648579 cites W1986397390 @default.
- W2004648579 cites W1986773457 @default.
- W2004648579 cites W1987568133 @default.
- W2004648579 cites W1987999251 @default.
- W2004648579 cites W1988471692 @default.
- W2004648579 cites W1988834123 @default.
- W2004648579 cites W1989769337 @default.
- W2004648579 cites W1991722650 @default.
- W2004648579 cites W1992919122 @default.
- W2004648579 cites W1993628493 @default.
- W2004648579 cites W1993898178 @default.
- W2004648579 cites W1994077631 @default.
- W2004648579 cites W1994427475 @default.
- W2004648579 cites W1994653620 @default.
- W2004648579 cites W1995320060 @default.
- W2004648579 cites W2001622142 @default.
- W2004648579 cites W2003542709 @default.
- W2004648579 cites W2003890969 @default.
- W2004648579 cites W2007510413 @default.
- W2004648579 cites W2013827851 @default.
- W2004648579 cites W2014437910 @default.
- W2004648579 cites W2014864286 @default.
- W2004648579 cites W2016565975 @default.
- W2004648579 cites W2016941225 @default.
- W2004648579 cites W2018554988 @default.
- W2004648579 cites W2019188597 @default.
- W2004648579 cites W2019364338 @default.
- W2004648579 cites W2027173654 @default.
- W2004648579 cites W2029833886 @default.
- W2004648579 cites W2031379784 @default.
- W2004648579 cites W2032739411 @default.
- W2004648579 cites W2033551149 @default.
- W2004648579 cites W2035551749 @default.
- W2004648579 cites W2037028025 @default.
- W2004648579 cites W2038526590 @default.
- W2004648579 cites W2039915169 @default.
- W2004648579 cites W2040116689 @default.
- W2004648579 cites W2041095980 @default.
- W2004648579 cites W2041286264 @default.
- W2004648579 cites W2042612658 @default.
- W2004648579 cites W2043105290 @default.
- W2004648579 cites W2043768346 @default.
- W2004648579 cites W2044393380 @default.
- W2004648579 cites W2044735066 @default.
- W2004648579 cites W2048251717 @default.
- W2004648579 cites W2051347938 @default.
- W2004648579 cites W2051352003 @default.
- W2004648579 cites W2052559439 @default.
- W2004648579 cites W2053727980 @default.
- W2004648579 cites W2056068893 @default.
- W2004648579 cites W2056830287 @default.
- W2004648579 cites W2058265235 @default.
- W2004648579 cites W2060320635 @default.
- W2004648579 cites W2061480740 @default.
- W2004648579 cites W2061932771 @default.
- W2004648579 cites W2062995866 @default.
- W2004648579 cites W2063061036 @default.
- W2004648579 cites W2065160323 @default.
- W2004648579 cites W2066194890 @default.
- W2004648579 cites W2067175985 @default.
- W2004648579 cites W2069125274 @default.
- W2004648579 cites W2069893631 @default.
- W2004648579 cites W2070718073 @default.
- W2004648579 cites W2071944517 @default.