FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004650064> ?p ?o ?g. }

• W2004650064 endingPage "310" @default.
• W2004650064 startingPage "303" @default.
• W2004650064 abstract "In this study we characterised the in vitro antitumour and hepatotoxicity profiles of a series of Au(I) and Ag(I) bidentate phenyl and pyridyl complexes in a panel of cisplatin-resistant human ovarian cancer cell-lines, and in isolated rat hepatocytes. The gold and silver compounds overcame cisplatin-resistance in the CH1-cisR, 41M-cisR and SKOV-3 cell-lines, and showed cytotoxic potencies strongly correlated with their lipophilicity. Complexes with phenyl or 2-pyridyl ligands had high antitumour and hepatotoxic potency and low selectivity between different cell-lines. Their cytotoxicity profiles were similar to classic mitochondrial poisons and an example of this type of compound was shown to accumulate preferentially in the mitochondria of cancer cells in a manner that depended upon the mitochondrial membrane potential. In contrast, complexes with 3- or 4-pyridyl ligands had low antitumour and hepatotoxic potency and cytotoxicity profiles similar to 2-deoxy-D-glucose. In addition, they showed high selectivity between different cell-lines that was not attributable to variation in uptake in different cell-types. The in vitro hepatotoxic potency of the series of gold and silver compounds varied by over 61-fold and was closely related to their lipophilicity and hepatocyte uptake. In conclusion, Au(I) and Ag(I) bidendate pyridyl phosphine complexes demonstrate activity against cisplatin-resistant human cancer cells and in vitro cytotoxicity that strongly depends upon their lipophilicity." @default.
• W2004650064 created "2016-06-24" @default.
• W2004650064 creator A5000208785 @default.
• W2004650064 creator A5025783509 @default.
• W2004650064 creator A5038498358 @default.
• W2004650064 creator A5048269061 @default.
• W2004650064 creator A5056481563 @default.
• W2004650064 creator A5061684371 @default.
• W2004650064 creator A5074741791 @default.
• W2004650064 creator A5081761546 @default.
• W2004650064 creator A5084661473 @default.
• W2004650064 creator A5088930878 @default.
• W2004650064 date "2008-02-01" @default.
• W2004650064 modified "2023-10-16" @default.
• W2004650064 title "In vitro antitumour and hepatotoxicity profiles of Au(I) and Ag(I) bidentate pyridyl phosphine complexes and relationships to cellular uptake" @default.
• W2004650064 cites W1491081581 @default.
• W2004650064 cites W1968841015 @default.
• W2004650064 cites W1974945118 @default.
• W2004650064 cites W1977064754 @default.
• W2004650064 cites W1978674137 @default.
• W2004650064 cites W1983114685 @default.
• W2004650064 cites W1984799406 @default.
• W2004650064 cites W1987158405 @default.
• W2004650064 cites W1987437563 @default.
• W2004650064 cites W1996509473 @default.
• W2004650064 cites W1998650088 @default.
• W2004650064 cites W2004875516 @default.
• W2004650064 cites W2006149546 @default.
• W2004650064 cites W2011499007 @default.
• W2004650064 cites W2019267635 @default.
• W2004650064 cites W2023461311 @default.
• W2004650064 cites W2024032328 @default.
• W2004650064 cites W2029463436 @default.
• W2004650064 cites W2035193450 @default.
• W2004650064 cites W2072482644 @default.
• W2004650064 cites W2074966669 @default.
• W2004650064 cites W2232233927 @default.
• W2004650064 cites W64341082 @default.
• W2004650064 doi "https://doi.org/10.1016/j.jinorgbio.2007.09.003" @default.
• W2004650064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18029019" @default.
• W2004650064 hasPublicationYear "2008" @default.
• W2004650064 type Work @default.
• W2004650064 sameAs 2004650064 @default.
• W2004650064 citedByCount "164" @default.
• W2004650064 countsByYear W20046500642012 @default.
• W2004650064 countsByYear W20046500642013 @default.
• W2004650064 countsByYear W20046500642014 @default.
• W2004650064 countsByYear W20046500642015 @default.
• W2004650064 countsByYear W20046500642016 @default.
• W2004650064 countsByYear W20046500642017 @default.
• W2004650064 countsByYear W20046500642018 @default.
• W2004650064 countsByYear W20046500642019 @default.
• W2004650064 countsByYear W20046500642020 @default.
• W2004650064 countsByYear W20046500642021 @default.
• W2004650064 countsByYear W20046500642022 @default.
• W2004650064 crossrefType "journal-article" @default.
• W2004650064 hasAuthorship W2004650064A5000208785 @default.
• W2004650064 hasAuthorship W2004650064A5025783509 @default.
• W2004650064 hasAuthorship W2004650064A5038498358 @default.
• W2004650064 hasAuthorship W2004650064A5048269061 @default.
• W2004650064 hasAuthorship W2004650064A5056481563 @default.
• W2004650064 hasAuthorship W2004650064A5061684371 @default.
• W2004650064 hasAuthorship W2004650064A5074741791 @default.
• W2004650064 hasAuthorship W2004650064A5081761546 @default.
• W2004650064 hasAuthorship W2004650064A5084661473 @default.
• W2004650064 hasAuthorship W2004650064A5088930878 @default.
• W2004650064 hasConcept C109316439 @default.
• W2004650064 hasConcept C115624301 @default.
• W2004650064 hasConcept C121608353 @default.
• W2004650064 hasConcept C178516000 @default.
• W2004650064 hasConcept C178790620 @default.
• W2004650064 hasConcept C185592680 @default.
• W2004650064 hasConcept C190283241 @default.
• W2004650064 hasConcept C201399114 @default.
• W2004650064 hasConcept C202751555 @default.
• W2004650064 hasConcept C2776200302 @default.
• W2004650064 hasConcept C2776694085 @default.
• W2004650064 hasConcept C2778239845 @default.
• W2004650064 hasConcept C54355233 @default.
• W2004650064 hasConcept C55493867 @default.
• W2004650064 hasConcept C57992300 @default.
• W2004650064 hasConcept C71240020 @default.
• W2004650064 hasConcept C81885089 @default.
• W2004650064 hasConcept C86803240 @default.
• W2004650064 hasConcept C96232424 @default.
• W2004650064 hasConceptScore W2004650064C109316439 @default.
• W2004650064 hasConceptScore W2004650064C115624301 @default.
• W2004650064 hasConceptScore W2004650064C121608353 @default.
• W2004650064 hasConceptScore W2004650064C178516000 @default.
• W2004650064 hasConceptScore W2004650064C178790620 @default.
• W2004650064 hasConceptScore W2004650064C185592680 @default.
• W2004650064 hasConceptScore W2004650064C190283241 @default.
• W2004650064 hasConceptScore W2004650064C201399114 @default.
• W2004650064 hasConceptScore W2004650064C202751555 @default.
• W2004650064 hasConceptScore W2004650064C2776200302 @default.
• W2004650064 hasConceptScore W2004650064C2776694085 @default.
• W2004650064 hasConceptScore W2004650064C2778239845 @default.
• W2004650064 hasConceptScore W2004650064C54355233 @default.

• next