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- W2004651565 abstract "Agmatine (4-aminobutyl guanidine) is one of the metabolites of L-arginine. It is synthesized by arginine decarboxylase (ADC) and hydrolysed by agmatinase. Agmatine is widely distributed in the brain and its concentration is similar to the other neurotransmitters concentrations. Because agmatine is synthesized in the brain, stored in synaptic vesicles, accumulated by uptake, released by depolarization and inactivated by agmatinase, it is considered to be a putative neurotransmitter. It is reported recently that agmatine improves memory but its mechanism of action is not elucidated yet. Agmatine is suggested to modulate nitric oxide synthesis by affecting nitric oxide synthase (NOS); it inhibits neuronal (nNOS) and inducible (iNOS) NOS, while stimulates endothelial (eNOS) type and elevates nitric oxide (NO) and cyclic GMP levels. NO is the key link between NMDA-mediated increases in cytoplasmic Ca 2+, LTP and synaptic plasticity which are essential for memory formation. Then the aim of this study was to assess if nitric oxide synthesis inhibition prevents agmatine improving effect on memory. Adult male Sprague-Dawely rats weighing 200-300 g were trained in a single session consisting of 8 trials. The probe test was done 24 hours later to assess memory retention. Saline, agmatine (40 mg/kg) and/or L-NAME (3 mg/kg) was administered immediately after training. While agmatine improved animals' performance in probe trial, L-NAME prevented that improving effect. The results showed that L-NAME (the inhibitor of nitric oxide synthesis) prevents agmatine-induced improving effect on memory. It seems that nitric oxide is involved in agmatine-induced memory improvement." @default.
- W2004651565 created "2016-06-24" @default.
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- W2004651565 date "2012-07-01" @default.
- W2004651565 modified "2023-10-16" @default.
- W2004651565 title "P4-232: Nitric oxide mediates agmatine-induced improvements in memory" @default.
- W2004651565 doi "https://doi.org/10.1016/j.jalz.2012.05.1937" @default.
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