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• W2004653921 abstract "alpha-Synuclein (SYN) is the major component of Lewy bodies, the neuropathological hallmarks of Parkinson's disease (PD). Missense mutations and multiplications of the SYN gene cause autosomal dominant inherited PD. Thus, SYN is implicated in the pathogenesis of PD. However, the mechanism whereby SYN promotes neurodegeneration remains unclear. Familial PD with SYN gene mutations are rare because the majority of PD is sporadic and emerging evidence indicates that sporadic PD may result from genetic and environmental risk factors including neuroinflammation. Hence, we examined the relationship between SYN dysfunction and neuroinflammation in mediating dopaminergic neurodegeneration in mice and dopaminergic neuronal cultures derived from wild-type SYN and mutant A53T SYN transgenic mice in a murine SYN-null (SYNKO) background (M7KO and M83KO, respectively). Stereotaxic injection of an inflammagen, lipopolysaccharide, into substantia nigra of these SYN genetically engineered mice induced similar inflammatory reactions. In M7KO and M83KO, but not in SYNKO mice, the neuroinflammation was associated with dopaminergic neuronal death and the accumulation of insoluble aggregated SYN as cytoplasmic inclusions in nigral neurons. Nitrated/oxidized SYN was detected in these inclusions and abatement of microglia-derived nitric oxide and superoxide provided significant neuroprotection in neuron-glia cultures from M7KO mice. These data suggest that nitric oxide and superoxide released by activated microglia may be mediators that link inflammation and abnormal SYN in mechanisms of PD neurodegeneration. This study advances understanding of the role of neuroinflammation and abnormal SYN in the pathogenesis of PD and opens new avenues for the discovery of more effective therapies for PD." @default.
• W2004653921 created "2016-06-24" @default.
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• W2004653921 date "2008-07-23" @default.
• W2004653921 modified "2023-09-30" @default.
• W2004653921 title "Neuroinflammation and Oxidation/Nitration of α-Synuclein Linked to Dopaminergic Neurodegeneration" @default.
• W2004653921 cites W1496790952 @default.
• W2004653921 cites W1500418512 @default.
• W2004653921 cites W1527671059 @default.
• W2004653921 cites W1530199299 @default.
• W2004653921 cites W1550083773 @default.
• W2004653921 cites W1561951468 @default.
• W2004653921 cites W1587360940 @default.
• W2004653921 cites W1626086977 @default.
• W2004653921 cites W1668344921 @default.
• W2004653921 cites W1823487357 @default.
• W2004653921 cites W1965111978 @default.
• W2004653921 cites W1965778124 @default.
• W2004653921 cites W1968800738 @default.
• W2004653921 cites W1971300927 @default.
• W2004653921 cites W1973703480 @default.
• W2004653921 cites W1974924674 @default.
• W2004653921 cites W1975722154 @default.
• W2004653921 cites W1976148085 @default.
• W2004653921 cites W1976316003 @default.
• W2004653921 cites W1978900128 @default.
• W2004653921 cites W1979216870 @default.
• W2004653921 cites W1979527613 @default.
• W2004653921 cites W1982233965 @default.
• W2004653921 cites W1989522802 @default.
• W2004653921 cites W1991805788 @default.
• W2004653921 cites W1994583626 @default.
• W2004653921 cites W1996355944 @default.
• W2004653921 cites W1997294033 @default.
• W2004653921 cites W2010612415 @default.
• W2004653921 cites W2010623074 @default.
• W2004653921 cites W2017476220 @default.
• W2004653921 cites W2021899761 @default.
• W2004653921 cites W2024041381 @default.
• W2004653921 cites W2025922492 @default.
• W2004653921 cites W2032247291 @default.
• W2004653921 cites W2039190334 @default.
• W2004653921 cites W2043676089 @default.
• W2004653921 cites W2049392449 @default.
• W2004653921 cites W2055094010 @default.
• W2004653921 cites W2056675110 @default.
• W2004653921 cites W2061154270 @default.
• W2004653921 cites W2061995199 @default.
• W2004653921 cites W2062024327 @default.
• W2004653921 cites W2080612740 @default.
• W2004653921 cites W2080949995 @default.
• W2004653921 cites W2084334114 @default.
• W2004653921 cites W2089900719 @default.
• W2004653921 cites W2090905739 @default.
• W2004653921 cites W2091265794 @default.
• W2004653921 cites W2092791231 @default.
• W2004653921 cites W2093412414 @default.
• W2004653921 cites W2100039520 @default.
• W2004653921 cites W2101371798 @default.
• W2004653921 cites W2102885748 @default.
• W2004653921 cites W2103738800 @default.
• W2004653921 cites W2105482032 @default.
• W2004653921 cites W2111442935 @default.
• W2004653921 cites W2113717530 @default.
• W2004653921 cites W2117442313 @default.
• W2004653921 cites W2120867735 @default.
• W2004653921 cites W2121272065 @default.
• W2004653921 cites W2122113931 @default.
• W2004653921 cites W2122291732 @default.
• W2004653921 cites W2123431154 @default.
• W2004653921 cites W2123548739 @default.
• W2004653921 cites W2124405216 @default.
• W2004653921 cites W2128631317 @default.
• W2004653921 cites W2142360514 @default.
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• W2004653921 cites W2148726772 @default.
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• W2004653921 cites W2154737306 @default.
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• W2004653921 cites W2165738847 @default.
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• W2004653921 doi "https://doi.org/10.1523/jneurosci.0143-07.2008" @default.
• W2004653921 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2702093" @default.
• W2004653921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18650345" @default.
• W2004653921 hasPublicationYear "2008" @default.
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