Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004656905> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2004656905 endingPage "4473" @default.
- W2004656905 startingPage "4463" @default.
- W2004656905 abstract "The oxidative cross-coupling of sulfonamide antimicrobials to constituents of natural organic matter was investigated. Sulfonamide antimicrobials were incubated with surrogate humic constituents in the absence and presence of phenoloxidases (viz., peroxidase, laccase, and tyrosinase) or acid birnessite. Substituted phenols were chosen as simple model constituents to determine the structures in humic substances important for cross-coupling reactions. The extent of sulfonamide transformation was evaluated by the disappearance of the parent compound from solution. Incubation with phenoloxidases in the absence of substituted phenols resulted in little or no sulfonamide transformation. In contrast to this, direct oxidation of sulfonamides by acid birnessite was significant. Inclusion of o-diphenols and 2,6-dimethoxyphenols in reaction mixtures resulted in significant phenoloxidase-mediated transformation of sulfonamides and enhanced antimicrobial transformation in the presence of acid birnessite. Phenolic compounds with other substitution patterns were less effective in promoting sulfonamide transformation. Nuclear magnetic resonance spectroscopy experiments provided direct evidence of peroxidase-mediated covalent cross-coupling of sulfamethazine with syringic and protocatechuic acids. Our results indicate that sulfonamide antimicrobials may be chemically incorporated into humic substances. This may result in their diminished mobility, bioavailability, and biological activity." @default.
- W2004656905 created "2016-06-24" @default.
- W2004656905 creator A5002625725 @default.
- W2004656905 creator A5006221583 @default.
- W2004656905 creator A5056404178 @default.
- W2004656905 date "2005-05-13" @default.
- W2004656905 modified "2023-10-03" @default.
- W2004656905 title "Cross-Coupling of Sulfonamide Antimicrobial Agents with Model Humic Constituents" @default.
- W2004656905 cites W1593881160 @default.
- W2004656905 cites W1977592347 @default.
- W2004656905 cites W1981182639 @default.
- W2004656905 cites W1985935637 @default.
- W2004656905 cites W1986007656 @default.
- W2004656905 cites W1988534433 @default.
- W2004656905 cites W1990067863 @default.
- W2004656905 cites W1993454504 @default.
- W2004656905 cites W1999685824 @default.
- W2004656905 cites W2003216555 @default.
- W2004656905 cites W2029162372 @default.
- W2004656905 cites W2051685049 @default.
- W2004656905 cites W2055458532 @default.
- W2004656905 cites W2057104903 @default.
- W2004656905 cites W2062156536 @default.
- W2004656905 cites W2064370066 @default.
- W2004656905 cites W2073534754 @default.
- W2004656905 cites W2095814927 @default.
- W2004656905 cites W2116281974 @default.
- W2004656905 cites W2152825159 @default.
- W2004656905 cites W4244806755 @default.
- W2004656905 cites W4255475194 @default.
- W2004656905 cites W4302447287 @default.
- W2004656905 doi "https://doi.org/10.1021/es0500916" @default.
- W2004656905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16047782" @default.
- W2004656905 hasPublicationYear "2005" @default.
- W2004656905 type Work @default.
- W2004656905 sameAs 2004656905 @default.
- W2004656905 citedByCount "166" @default.
- W2004656905 countsByYear W20046569052012 @default.
- W2004656905 countsByYear W20046569052013 @default.
- W2004656905 countsByYear W20046569052014 @default.
- W2004656905 countsByYear W20046569052015 @default.
- W2004656905 countsByYear W20046569052016 @default.
- W2004656905 countsByYear W20046569052017 @default.
- W2004656905 countsByYear W20046569052018 @default.
- W2004656905 countsByYear W20046569052019 @default.
- W2004656905 countsByYear W20046569052020 @default.
- W2004656905 countsByYear W20046569052021 @default.
- W2004656905 countsByYear W20046569052022 @default.
- W2004656905 countsByYear W20046569052023 @default.
- W2004656905 crossrefType "journal-article" @default.
- W2004656905 hasAuthorship W2004656905A5002625725 @default.
- W2004656905 hasAuthorship W2004656905A5006221583 @default.
- W2004656905 hasAuthorship W2004656905A5056404178 @default.
- W2004656905 hasConcept C178790620 @default.
- W2004656905 hasConcept C185592680 @default.
- W2004656905 hasConcept C2777728882 @default.
- W2004656905 hasConcept C2781039511 @default.
- W2004656905 hasConcept C4937899 @default.
- W2004656905 hasConceptScore W2004656905C178790620 @default.
- W2004656905 hasConceptScore W2004656905C185592680 @default.
- W2004656905 hasConceptScore W2004656905C2777728882 @default.
- W2004656905 hasConceptScore W2004656905C2781039511 @default.
- W2004656905 hasConceptScore W2004656905C4937899 @default.
- W2004656905 hasIssue "12" @default.
- W2004656905 hasLocation W20046569051 @default.
- W2004656905 hasLocation W20046569052 @default.
- W2004656905 hasOpenAccess W2004656905 @default.
- W2004656905 hasPrimaryLocation W20046569051 @default.
- W2004656905 hasRelatedWork W1981870462 @default.
- W2004656905 hasRelatedWork W1996711136 @default.
- W2004656905 hasRelatedWork W2095212420 @default.
- W2004656905 hasRelatedWork W2317452413 @default.
- W2004656905 hasRelatedWork W2396822601 @default.
- W2004656905 hasRelatedWork W2403580444 @default.
- W2004656905 hasRelatedWork W2951803252 @default.
- W2004656905 hasRelatedWork W2952186766 @default.
- W2004656905 hasRelatedWork W4252524260 @default.
- W2004656905 hasRelatedWork W4313409759 @default.
- W2004656905 hasVolume "39" @default.
- W2004656905 isParatext "false" @default.
- W2004656905 isRetracted "false" @default.
- W2004656905 magId "2004656905" @default.
- W2004656905 workType "article" @default.