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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004657066> ?p ?o ?g. }

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• W2004657066 abstract "Cultured human umbilical vein endothelial cells inhibited the platelet aggregating activity of thrombin in the absence of plasma. Using a new method in which thrombin-induced platelet aggregation was measured in the presence of endothelial cells, we showed that aspirin-treated endothelial cells inhibited platelet aggregating activity of thrombin in an incubation time- and cell number-dependent manner. This inhibitory effect of endothelial cells was partially blocked by the pretreatment of endothelial cells with monoclonal anti-thrombomodulin IgG (anti-TMIgG). It is suggested that (1) endothelial cells play a role in the clearance of thrombin by binding and inactivating this enzyme and that (2) thrombomodulin on endothelial cells, apart from its role for protein C activation, may be involved in this endothelial function." @default.
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• W2004657066 date "1988-06-01" @default.
• W2004657066 modified "2023-10-16" @default.
• W2004657066 title "Inhibition by endothelial cells of platelet aggregating activity of thrombin - role of thrombomodulin" @default.
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• W2004657066 doi "https://doi.org/10.1016/0049-3848(88)90323-4" @default.
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