FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004657239> ?p ?o ?g. }

• W2004657239 endingPage "672" @default.
• W2004657239 startingPage "665" @default.
• W2004657239 abstract "The immunological parameters leading to viral persistence in chronic hepatitis B (CHB) are not clearly established. We analyzed HBV-specific immunoregulatory mechanisms in HIV-infected and HIV-uninfected HBeAg+ CHB patients to determine (1) the roles of immunoregulatory pathways, (2) the effect of anti-HBV therapy on immunoregulatory pathways, and (3) the role of immunomodulatory therapy to overcome the effect of T regulatory cells (Tregs, CD4+CD25+FoxP3+) in HBV-infected individuals. A prospective, double blind, randomized, placebo-controlled trial treated HBV (HIV+/–)-infected patients with adefovir 10 mg daily or placebo for 48 weeks. HBV viral load (VL), immunophenotying, and functional studies were performed at multiple time points. Suppression of HBV VL with adefovir leads to decreased peripheral expansion of Tregs. While declining, Tregs significantly inhibit cytokine-secreting HBV-specific CD8+ T cell responses over 48 weeks of anti-HBV adefovir therapy (p<0.05). A large proportion of these Tregs express programmed death receptor-1 (PD-1), blockade of which in vitro leads to improved cytokine-secreting HBV-specific CD8+ T cell responses, particularly in HIV/HBV-coinfected patients (p<0.05). Peripheral expansion of Treg levels correlated with HBV viral load and decreased HBV-specific CD8+ T cells. PD-1 blockade increased survival of HBV-specific CD8+ T cells, removing the inhibitory effect of PD-1+ peripheral Tregs. Hence therapies involving PD-1 blockade in combination with directly acting antivirals should be investigated to reduce the need for life-long directly acting antiviral therapy." @default.
• W2004657239 created "2016-06-24" @default.
• W2004657239 creator A5026415059 @default.
• W2004657239 creator A5031884118 @default.
• W2004657239 creator A5033188792 @default.
• W2004657239 creator A5043752885 @default.
• W2004657239 creator A5044817385 @default.
• W2004657239 creator A5050849376 @default.
• W2004657239 creator A5050880173 @default.
• W2004657239 creator A5068358102 @default.
• W2004657239 date "2013-04-01" @default.
• W2004657239 modified "2023-09-30" @default.
• W2004657239 title "Augmentation of Hepatitis B Virus-Specific Cellular Immunity with Programmed Death Receptor-1/Programmed Death Receptor-L1 Blockade in Hepatitis B Virus and HIV/Hepatitis B Virus Coinfected Patients Treated with Adefovir" @default.
• W2004657239 cites W1494034388 @default.
• W2004657239 cites W1976347185 @default.
• W2004657239 cites W1977583523 @default.
• W2004657239 cites W1983251878 @default.
• W2004657239 cites W2003197307 @default.
• W2004657239 cites W2003787000 @default.
• W2004657239 cites W2004054613 @default.
• W2004657239 cites W2007202675 @default.
• W2004657239 cites W2011022219 @default.
• W2004657239 cites W2013013791 @default.
• W2004657239 cites W2013601398 @default.
• W2004657239 cites W2013844300 @default.
• W2004657239 cites W2015035059 @default.
• W2004657239 cites W2027355270 @default.
• W2004657239 cites W2038669470 @default.
• W2004657239 cites W2048056516 @default.
• W2004657239 cites W2050607746 @default.
• W2004657239 cites W2053325353 @default.
• W2004657239 cites W2053746998 @default.
• W2004657239 cites W2055270948 @default.
• W2004657239 cites W2058636963 @default.
• W2004657239 cites W2062563125 @default.
• W2004657239 cites W2069138927 @default.
• W2004657239 cites W2078891362 @default.
• W2004657239 cites W2096094255 @default.
• W2004657239 cites W2103529803 @default.
• W2004657239 cites W2149748445 @default.
• W2004657239 cites W2152664737 @default.
• W2004657239 cites W2158393416 @default.
• W2004657239 cites W2166889324 @default.
• W2004657239 cites W2167390007 @default.
• W2004657239 cites W2167590969 @default.
• W2004657239 cites W4251604809 @default.
• W2004657239 doi "https://doi.org/10.1089/aid.2012.0320" @default.
• W2004657239 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3607907" @default.
• W2004657239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23259453" @default.
• W2004657239 hasPublicationYear "2013" @default.
• W2004657239 type Work @default.
• W2004657239 sameAs 2004657239 @default.
• W2004657239 citedByCount "28" @default.
• W2004657239 countsByYear W20046572392013 @default.
• W2004657239 countsByYear W20046572392014 @default.
• W2004657239 countsByYear W20046572392015 @default.
• W2004657239 countsByYear W20046572392016 @default.
• W2004657239 countsByYear W20046572392017 @default.
• W2004657239 countsByYear W20046572392019 @default.
• W2004657239 countsByYear W20046572392020 @default.
• W2004657239 countsByYear W20046572392022 @default.
• W2004657239 crossrefType "journal-article" @default.
• W2004657239 hasAuthorship W2004657239A5026415059 @default.
• W2004657239 hasAuthorship W2004657239A5031884118 @default.
• W2004657239 hasAuthorship W2004657239A5033188792 @default.
• W2004657239 hasAuthorship W2004657239A5043752885 @default.
• W2004657239 hasAuthorship W2004657239A5044817385 @default.
• W2004657239 hasAuthorship W2004657239A5050849376 @default.
• W2004657239 hasAuthorship W2004657239A5050880173 @default.
• W2004657239 hasAuthorship W2004657239A5068358102 @default.
• W2004657239 hasBestOaLocation W20046572392 @default.
• W2004657239 hasConcept C142462285 @default.
• W2004657239 hasConcept C159047783 @default.
• W2004657239 hasConcept C167672396 @default.
• W2004657239 hasConcept C203014093 @default.
• W2004657239 hasConcept C2522874641 @default.
• W2004657239 hasConcept C2777382497 @default.
• W2004657239 hasConcept C2777869810 @default.
• W2004657239 hasConcept C2779517838 @default.
• W2004657239 hasConcept C2779727006 @default.
• W2004657239 hasConcept C2780593183 @default.
• W2004657239 hasConcept C71924100 @default.
• W2004657239 hasConcept C8891405 @default.
• W2004657239 hasConceptScore W2004657239C142462285 @default.
• W2004657239 hasConceptScore W2004657239C159047783 @default.
• W2004657239 hasConceptScore W2004657239C167672396 @default.
• W2004657239 hasConceptScore W2004657239C203014093 @default.
• W2004657239 hasConceptScore W2004657239C2522874641 @default.
• W2004657239 hasConceptScore W2004657239C2777382497 @default.
• W2004657239 hasConceptScore W2004657239C2777869810 @default.
• W2004657239 hasConceptScore W2004657239C2779517838 @default.
• W2004657239 hasConceptScore W2004657239C2779727006 @default.
• W2004657239 hasConceptScore W2004657239C2780593183 @default.
• W2004657239 hasConceptScore W2004657239C71924100 @default.
• W2004657239 hasConceptScore W2004657239C8891405 @default.
• W2004657239 hasIssue "4" @default.
• W2004657239 hasLocation W20046572391 @default.
• W2004657239 hasLocation W20046572392 @default.

• next