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- W2004659260 abstract "A bicycle built for Grb2: We report a strategy for stabilizing peptide macrocycles by introducing side-chain-to-side-chain staples, producing peptide bicycles with higher affinity, selectivity, and resistance to degradation. We have applied this strategy to develop a small, serum-stable peptide bicycle that inhibits Grb2-SH2 60-fold more potently and 200-fold more selectively than a parent peptide." @default.
- W2004659260 created "2016-06-24" @default.
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- W2004659260 date "2012-06-11" @default.
- W2004659260 modified "2023-09-23" @default.
- W2004659260 title "Peptide Bicycles that Inhibit the Grb2 SH2 Domain" @default.
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- W2004659260 doi "https://doi.org/10.1002/cbic.201200175" @default.
- W2004659260 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3516885" @default.
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