FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004661177> ?p ?o ?g. }

• W2004661177 endingPage "433" @default.
• W2004661177 startingPage "422" @default.
• W2004661177 abstract "This report describes a genetic locus associated with siderophore biosynthesis and transport in Corynebacterium diphtheriae. A BLAST search of the C. diphtheriae genome identified a seven-gene cluster that included four genes, designated ciuA, ciuB, ciuC, and ciuD, whose predicted products are related to ABC-type iron transporters. Downstream from ciuD is the ciuE gene, whose predicted product is similar to the aerobactin biosynthetic enzymes IucA and IucC. The CiuE protein, which has a predicted mass of 121,582 Da and is approximately twice the size of either IucC or IucA, is homologous to each of these proteins in both its N- and C-terminal regions. C. diphtheriae ciuE deletion mutants exhibited a defect in siderophore production, iron uptake, and growth in low-iron medium. Mutations in the ciuA gene, whose predicted product is a lipoprotein component of an iron transport system, resulted in a severe defect in iron uptake and reduced ability to use the C. diphtheriae siderophore as an iron source. Site-directed mutations in irp6A, a gene previously reported to be associated with siderophore transport, had no effect on iron uptake or the utilization of the C. diphtheriae siderophore as an iron source. Transcriptional analysis demonstrated that expression of ciuA and ciuE is DtxR and iron regulated, and DNase I protection experiments confirmed the presence of DtxR binding sites upstream from each of these genes. Thus, this iron- and DtxR-regulated gene cluster is involved in the synthesis and transport of the C. diphtheriae siderophore." @default.
• W2004661177 created "2016-06-24" @default.
• W2004661177 creator A5055566096 @default.
• W2004661177 creator A5083556239 @default.
• W2004661177 date "2005-01-15" @default.
• W2004661177 modified "2023-10-13" @default.
• W2004661177 title "Analysis of a DtxR-Regulated Iron Transport and Siderophore Biosynthesis Gene Cluster in <i>Corynebacterium diphtheriae</i>" @default.
• W2004661177 cites W1485153163 @default.
• W2004661177 cites W1515226138 @default.
• W2004661177 cites W1549021910 @default.
• W2004661177 cites W1561893393 @default.
• W2004661177 cites W1624613149 @default.
• W2004661177 cites W1820859920 @default.
• W2004661177 cites W1876284681 @default.
• W2004661177 cites W1931700765 @default.
• W2004661177 cites W1963029721 @default.
• W2004661177 cites W1967073350 @default.
• W2004661177 cites W1969043511 @default.
• W2004661177 cites W1978156984 @default.
• W2004661177 cites W1987329985 @default.
• W2004661177 cites W1995580146 @default.
• W2004661177 cites W1997221462 @default.
• W2004661177 cites W1998561479 @default.
• W2004661177 cites W2013740990 @default.
• W2004661177 cites W2015473213 @default.
• W2004661177 cites W2016361506 @default.
• W2004661177 cites W2019600378 @default.
• W2004661177 cites W2027229485 @default.
• W2004661177 cites W2033377436 @default.
• W2004661177 cites W2041491105 @default.
• W2004661177 cites W2049297824 @default.
• W2004661177 cites W2055043387 @default.
• W2004661177 cites W2069128869 @default.
• W2004661177 cites W2088167775 @default.
• W2004661177 cites W2095979534 @default.
• W2004661177 cites W2104289834 @default.
• W2004661177 cites W2107991524 @default.
• W2004661177 cites W2108988287 @default.
• W2004661177 cites W2110299699 @default.
• W2004661177 cites W2121925112 @default.
• W2004661177 cites W2128022667 @default.
• W2004661177 cites W2129436100 @default.
• W2004661177 cites W2129551736 @default.
• W2004661177 cites W2138059206 @default.
• W2004661177 cites W2147044065 @default.
• W2004661177 cites W2151863305 @default.
• W2004661177 cites W2153076508 @default.
• W2004661177 cites W2176699307 @default.
• W2004661177 cites W2178477917 @default.
• W2004661177 cites W2235355521 @default.
• W2004661177 cites W258326343 @default.
• W2004661177 doi "https://doi.org/10.1128/jb.187.2.422-433.2005" @default.
• W2004661177 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/543566" @default.
• W2004661177 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15629913" @default.
• W2004661177 hasPublicationYear "2005" @default.
• W2004661177 type Work @default.
• W2004661177 sameAs 2004661177 @default.
• W2004661177 citedByCount "55" @default.
• W2004661177 countsByYear W20046611772012 @default.
• W2004661177 countsByYear W20046611772013 @default.
• W2004661177 countsByYear W20046611772014 @default.
• W2004661177 countsByYear W20046611772015 @default.
• W2004661177 countsByYear W20046611772016 @default.
• W2004661177 countsByYear W20046611772017 @default.
• W2004661177 countsByYear W20046611772018 @default.
• W2004661177 countsByYear W20046611772019 @default.
• W2004661177 countsByYear W20046611772020 @default.
• W2004661177 countsByYear W20046611772021 @default.
• W2004661177 countsByYear W20046611772022 @default.
• W2004661177 countsByYear W20046611772023 @default.
• W2004661177 crossrefType "journal-article" @default.
• W2004661177 hasAuthorship W2004661177A5055566096 @default.
• W2004661177 hasAuthorship W2004661177A5083556239 @default.
• W2004661177 hasBestOaLocation W20046611771 @default.
• W2004661177 hasConcept C104317684 @default.
• W2004661177 hasConcept C108319773 @default.
• W2004661177 hasConcept C143065580 @default.
• W2004661177 hasConcept C149011108 @default.
• W2004661177 hasConcept C203014093 @default.
• W2004661177 hasConcept C22070199 @default.
• W2004661177 hasConcept C2780572238 @default.
• W2004661177 hasConcept C2781288345 @default.
• W2004661177 hasConcept C36857842 @default.
• W2004661177 hasConcept C44312359 @default.
• W2004661177 hasConcept C54355233 @default.
• W2004661177 hasConcept C55493867 @default.
• W2004661177 hasConcept C86803240 @default.
• W2004661177 hasConcept C89423630 @default.
• W2004661177 hasConceptScore W2004661177C104317684 @default.
• W2004661177 hasConceptScore W2004661177C108319773 @default.
• W2004661177 hasConceptScore W2004661177C143065580 @default.
• W2004661177 hasConceptScore W2004661177C149011108 @default.
• W2004661177 hasConceptScore W2004661177C203014093 @default.
• W2004661177 hasConceptScore W2004661177C22070199 @default.
• W2004661177 hasConceptScore W2004661177C2780572238 @default.
• W2004661177 hasConceptScore W2004661177C2781288345 @default.
• W2004661177 hasConceptScore W2004661177C36857842 @default.
• W2004661177 hasConceptScore W2004661177C44312359 @default.

• next