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- W2004664535 abstract "The effects of bombesin on hypothalamic suprachiasmatic (SCN) neurons were tested in this study using extracellular single-unit recording in brain tissue slices. Fresh slices containing the SCN were obtained from adult ovariectomized Sprague-Dawley rats. Bombesin in pmol ranges stimulated 75% of irregular firing SCN neurons (n = 113), while it stimulated and inhibited 17% and 34% of regular firing units, respectively. Half of the regular firing SCN units, however, were not responsive to bombesin (49% of 61 units). A dose-dependent (from 5 to 500 pmol) excitatory effect of bombesin on SCN neurons was also observed. Pretreatment with [Leu13-ψ(CH2NH)-Leu14]-bombesin, a bombesin receptor antagonist, blocked the action of bombesin in 67% of 18 units responded to bombesin, indicating a specific receptor is involved in the action. Gastrin-releasing peptide, a well-recognized bombesin-like peptide in mammals, behaved almost the same as bombesin did in most SCN neurons tested (same responses in 24 of 25 units). The present finding indicates that bombesin-like peptides may play a significant role in the SCN for the rhythmic control mechanism." @default.
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- W2004664535 title "Stimulatory effects of bombesin-like peptides on suprachiasmatic neurons in brain slices" @default.
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- W2004664535 doi "https://doi.org/10.1016/0006-8993(93)91025-n" @default.
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