Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004665631> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2004665631 endingPage "421" @default.
- W2004665631 startingPage "415" @default.
- W2004665631 abstract "Abstract The in-vitro selectivity of a group of substituted benzamide drugs for brain neurotransmitter receptors was determined to assess the most appropriate drugs for use in human PET studies. All substituted benzamide drugs studied inhibited [3H]haloperidol and [3H]spiperone binding to rat striatal membranes. The most potent compounds were YM 09151-2, clebopride and raclopride. However, these substances also interacted in differing degrees with α-l, α-2, β-adrenergic, 5-HT-1, 5-HT-2, and opiate sites. Sulpiride, alizapride, SL 74205, TER 1546 and tiapride were specific for D-2 receptors, but these drugs were active only in the 10−7–10−6 M range. Raclopride, amisulpiride and sultopride showed a 100–1000 differentiation between action on dopamine sites compared with other neurotransmitter receptors. No such selectivity was observed for clebopride or YM 09151-2. Specific substituted benzamides such as alizapride, may be appropriate in high concentrations for defining the interaction of PET ligands with brain dopamine receptors. More potent, but selective, drugs such as raclopride and amisulpiride, may be effective in low concentrations as ligands for labelling dopamine receptor sites. However, the ability of these various substituted benzamide drugs to penetrate into brain and in-vivo to identify dopamine receptors in all brain areas must be assessed." @default.
- W2004665631 created "2016-06-24" @default.
- W2004665631 creator A5030909442 @default.
- W2004665631 creator A5036018066 @default.
- W2004665631 creator A5056222385 @default.
- W2004665631 creator A5066146195 @default.
- W2004665631 creator A5085926729 @default.
- W2004665631 date "1988-06-01" @default.
- W2004665631 modified "2023-10-03" @default.
- W2004665631 title "Comparison of the In-vitro Receptor Selectivity of Substituted Benzamide Drugs for Brain Neurotransmitter Receptors" @default.
- W2004665631 cites W1501384344 @default.
- W2004665631 cites W2017620204 @default.
- W2004665631 cites W2022859491 @default.
- W2004665631 cites W2042592920 @default.
- W2004665631 cites W2044706500 @default.
- W2004665631 cites W2057298318 @default.
- W2004665631 cites W2064401216 @default.
- W2004665631 cites W2066735646 @default.
- W2004665631 cites W2073711860 @default.
- W2004665631 cites W2074830397 @default.
- W2004665631 cites W2077760177 @default.
- W2004665631 cites W2091516479 @default.
- W2004665631 cites W2140365112 @default.
- W2004665631 cites W2319541300 @default.
- W2004665631 cites W2483212900 @default.
- W2004665631 cites W4240989473 @default.
- W2004665631 doi "https://doi.org/10.1111/j.2042-7158.1988.tb06306.x" @default.
- W2004665631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2901473" @default.
- W2004665631 hasPublicationYear "1988" @default.
- W2004665631 type Work @default.
- W2004665631 sameAs 2004665631 @default.
- W2004665631 citedByCount "55" @default.
- W2004665631 countsByYear W20046656312014 @default.
- W2004665631 countsByYear W20046656312017 @default.
- W2004665631 countsByYear W20046656312018 @default.
- W2004665631 countsByYear W20046656312020 @default.
- W2004665631 countsByYear W20046656312022 @default.
- W2004665631 countsByYear W20046656312023 @default.
- W2004665631 crossrefType "journal-article" @default.
- W2004665631 hasAuthorship W2004665631A5030909442 @default.
- W2004665631 hasAuthorship W2004665631A5036018066 @default.
- W2004665631 hasAuthorship W2004665631A5056222385 @default.
- W2004665631 hasAuthorship W2004665631A5066146195 @default.
- W2004665631 hasAuthorship W2004665631A5085926729 @default.
- W2004665631 hasConcept C120069818 @default.
- W2004665631 hasConcept C126322002 @default.
- W2004665631 hasConcept C156927020 @default.
- W2004665631 hasConcept C170493617 @default.
- W2004665631 hasConcept C185592680 @default.
- W2004665631 hasConcept C2776219046 @default.
- W2004665631 hasConcept C2779271588 @default.
- W2004665631 hasConcept C2780231548 @default.
- W2004665631 hasConcept C2781069445 @default.
- W2004665631 hasConcept C2781073084 @default.
- W2004665631 hasConcept C44208683 @default.
- W2004665631 hasConcept C513476851 @default.
- W2004665631 hasConcept C55493867 @default.
- W2004665631 hasConcept C71240020 @default.
- W2004665631 hasConcept C71924100 @default.
- W2004665631 hasConcept C86803240 @default.
- W2004665631 hasConcept C98274493 @default.
- W2004665631 hasConceptScore W2004665631C120069818 @default.
- W2004665631 hasConceptScore W2004665631C126322002 @default.
- W2004665631 hasConceptScore W2004665631C156927020 @default.
- W2004665631 hasConceptScore W2004665631C170493617 @default.
- W2004665631 hasConceptScore W2004665631C185592680 @default.
- W2004665631 hasConceptScore W2004665631C2776219046 @default.
- W2004665631 hasConceptScore W2004665631C2779271588 @default.
- W2004665631 hasConceptScore W2004665631C2780231548 @default.
- W2004665631 hasConceptScore W2004665631C2781069445 @default.
- W2004665631 hasConceptScore W2004665631C2781073084 @default.
- W2004665631 hasConceptScore W2004665631C44208683 @default.
- W2004665631 hasConceptScore W2004665631C513476851 @default.
- W2004665631 hasConceptScore W2004665631C55493867 @default.
- W2004665631 hasConceptScore W2004665631C71240020 @default.
- W2004665631 hasConceptScore W2004665631C71924100 @default.
- W2004665631 hasConceptScore W2004665631C86803240 @default.
- W2004665631 hasConceptScore W2004665631C98274493 @default.
- W2004665631 hasIssue "6" @default.
- W2004665631 hasLocation W20046656311 @default.
- W2004665631 hasLocation W20046656312 @default.
- W2004665631 hasOpenAccess W2004665631 @default.
- W2004665631 hasPrimaryLocation W20046656311 @default.
- W2004665631 hasRelatedWork W187595635 @default.
- W2004665631 hasRelatedWork W1963961674 @default.
- W2004665631 hasRelatedWork W2004665631 @default.
- W2004665631 hasRelatedWork W2032818185 @default.
- W2004665631 hasRelatedWork W2037845946 @default.
- W2004665631 hasRelatedWork W2073811833 @default.
- W2004665631 hasRelatedWork W2095529697 @default.
- W2004665631 hasRelatedWork W2097260594 @default.
- W2004665631 hasRelatedWork W2122991783 @default.
- W2004665631 hasRelatedWork W4224302975 @default.
- W2004665631 hasVolume "40" @default.
- W2004665631 isParatext "false" @default.
- W2004665631 isRetracted "false" @default.
- W2004665631 magId "2004665631" @default.
- W2004665631 workType "article" @default.