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- W2004666525 endingPage "455" @default.
- W2004666525 startingPage "445" @default.
- W2004666525 abstract "Transforming growth factor-β (TGF-β) has roles in embryonic development, the prevention of inappropriate inflammation and tumour suppression. However, TGF-β signalling also regulates pathological epithelial-to-mesenchymal transition (EMT), inducing or progressing a number of diseases ranging from inflammatory disorders, to fibrosis and cancer. However, TGF-β signalling does not proceed linearly but rather induces a complex network of cascades that mutually influence each other and cross-talk with other pathways to successfully induce EMT. Particularly, there is substantial evidence for cross-talk between αV integrins and TGF-β during EMT, and anti-integrin therapeutics are under development as treatments for TGF-β-related disorders. However, TGF-β's complex signalling network makes the development of therapeutics to block TGF-β-mediated pathology challenging. Moreover, despite our current understanding of integrins and TGF-β function during EMT, the precise mechanism of their role during physiological versus pathological EMT is not fully understood. This review focuses on the circle of regulation between αV integrin and TGF-β signalling during TGF-β induced EMT, which pose as a significant driver to many known TGF-β-mediated disorders." @default.
- W2004666525 created "2016-06-24" @default.
- W2004666525 creator A5010301642 @default.
- W2004666525 creator A5017300601 @default.
- W2004666525 date "2012-02-28" @default.
- W2004666525 modified "2023-09-29" @default.
- W2004666525 title "aV integrins and TGF-β-induced EMT: a circle of regulation" @default.
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