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- W2004669097 abstract "Antineoplastic agents of the nitrosourea class also have antisickling properties. It has been shown that compounds such as BCNU (1,3-bis-(2-chloroethyl)-1-nitrosourea) decompose under physiological conditions and give rise to substituted isocyanates. The latter are carbamylating agents and, presumably, through such activity have antisickling and antineoplastic activity. In fresh liver homogenates (at 0–4°C) cyanate and 2-chloroethyl isocyanate caused conversion of tyrosine aminotransferase form I to form III. This did not occur with the parent compound BCNU. However, liver homogenates prepared from rats pretreated with BCNU contained significantly more tyrosine aminotransferase form III than controls. Considering the effects that cyanate and isocyanate have on hemoglobin and tyrosine aminotransferase, it is possible that the antineoplastic activity of the nitrosoureas is due to carbamylation of specific regulators of cell division." @default.
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- W2004669097 date "1974-08-01" @default.
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- W2004669097 title "Alteration of tyrosine aminotransferase multiple form patterns by antisickling agents and a decomposition product of antitumor agents" @default.
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- W2004669097 doi "https://doi.org/10.1016/0006-291x(74)90447-1" @default.
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