FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004669541> ?p ?o ?g. }

• W2004669541 endingPage "1010" @default.
• W2004669541 startingPage "1002" @default.
• W2004669541 abstract "Background The aim of this study was to evaluate the endoscopic and the histologic effects of a balloon-based bipolar radiofrequency electrode for ablation of porcine and human esophageal epithelium. Methods All procedures were performed with a balloon-based, bipolar radiofrequency system that creates a circumferential, thin-layer epithelial ablation zone within the esophagus. In Phase I, multiple ablations were created in 10 farm swine, followed by acute euthanasia and histologic assessment for completeness of epithelial removal and ablation depth. In Phase II, multiple ablations were created in 19 farm swine, with varying power and energy density, followed by endoscopy at 2 and 4 weeks to assess stricture formation. In Phase III, 3 ablations were created in 12 farm swine, with varying energy density (5, 8, 10, 12, 15, or 20 J/cm2) at 350 W. Animals were euthanized at 48 hours. Histologic examination determined the percentage of epithelium removed and the ablation depth. In Phase IV, 3 patients underwent esophageal epithelial ablation before esophagectomy, creating separate lesions proximal to the tumor. Completeness of epithelial ablation and ablation depth was quantified histologically. Results In Phase I, complete removal of esophageal epithelium was achieved at energy density settings of 9.7 to 29.5 J/cm2. In Phase II, 9.7 and 10.6 J/cm2 produced no stricture, whereas more than 20 J/cm2 produced a stricture in every case. In Phase III, 8-20 J/cm2 resulted in 100% epithelial ablation. Five and 8 J/cm2 spared the muscularis mucosae, whereas 10 J/cm2 caused injury to the muscularis mucosae but preserved the submucosa. In Phase IV, histologic examination demonstrated full-thickness epithelial removal in areas of electrode contact. Ablation extended only to the muscularis mucosae, without injury to submucosa. Conclusions In the porcine and the human esophagus, circumferential, full-thickness ablation of epithelium without direct injury to the submucosa is possible and was well tolerated. In all cases, depth of ablation was linearly related to energy density of treatment. The aim of this study was to evaluate the endoscopic and the histologic effects of a balloon-based bipolar radiofrequency electrode for ablation of porcine and human esophageal epithelium. All procedures were performed with a balloon-based, bipolar radiofrequency system that creates a circumferential, thin-layer epithelial ablation zone within the esophagus. In Phase I, multiple ablations were created in 10 farm swine, followed by acute euthanasia and histologic assessment for completeness of epithelial removal and ablation depth. In Phase II, multiple ablations were created in 19 farm swine, with varying power and energy density, followed by endoscopy at 2 and 4 weeks to assess stricture formation. In Phase III, 3 ablations were created in 12 farm swine, with varying energy density (5, 8, 10, 12, 15, or 20 J/cm2) at 350 W. Animals were euthanized at 48 hours. Histologic examination determined the percentage of epithelium removed and the ablation depth. In Phase IV, 3 patients underwent esophageal epithelial ablation before esophagectomy, creating separate lesions proximal to the tumor. Completeness of epithelial ablation and ablation depth was quantified histologically. In Phase I, complete removal of esophageal epithelium was achieved at energy density settings of 9.7 to 29.5 J/cm2. In Phase II, 9.7 and 10.6 J/cm2 produced no stricture, whereas more than 20 J/cm2 produced a stricture in every case. In Phase III, 8-20 J/cm2 resulted in 100% epithelial ablation. Five and 8 J/cm2 spared the muscularis mucosae, whereas 10 J/cm2 caused injury to the muscularis mucosae but preserved the submucosa. In Phase IV, histologic examination demonstrated full-thickness epithelial removal in areas of electrode contact. Ablation extended only to the muscularis mucosae, without injury to submucosa. In the porcine and the human esophagus, circumferential, full-thickness ablation of epithelium without direct injury to the submucosa is possible and was well tolerated. In all cases, depth of ablation was linearly related to energy density of treatment." @default.
• W2004669541 created "2016-06-24" @default.
• W2004669541 creator A5009421635 @default.
• W2004669541 creator A5027802532 @default.
• W2004669541 creator A5042870776 @default.
• W2004669541 creator A5062610703 @default.
• W2004669541 creator A5077005929 @default.
• W2004669541 creator A5079695722 @default.
• W2004669541 date "2004-12-01" @default.
• W2004669541 modified "2023-09-30" @default.
• W2004669541 title "Complete ablation of esophageal epithelium with a balloon-based bipolar electrode: a phased evaluation in the porcine and in the human esophagus" @default.
• W2004669541 cites W1965504968 @default.
• W2004669541 cites W1970359463 @default.
• W2004669541 cites W1986179816 @default.
• W2004669541 cites W199331381 @default.
• W2004669541 cites W2017593085 @default.
• W2004669541 cites W2022840630 @default.
• W2004669541 cites W2047824989 @default.
• W2004669541 cites W2073696403 @default.
• W2004669541 cites W2141102775 @default.
• W2004669541 cites W2409395041 @default.
• W2004669541 doi "https://doi.org/10.1016/s0016-5107(04)02220-5" @default.
• W2004669541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15605025" @default.
• W2004669541 hasPublicationYear "2004" @default.
• W2004669541 type Work @default.
• W2004669541 sameAs 2004669541 @default.
• W2004669541 citedByCount "162" @default.
• W2004669541 countsByYear W20046695412012 @default.
• W2004669541 countsByYear W20046695412013 @default.
• W2004669541 countsByYear W20046695412014 @default.
• W2004669541 countsByYear W20046695412015 @default.
• W2004669541 countsByYear W20046695412016 @default.
• W2004669541 countsByYear W20046695412017 @default.
• W2004669541 countsByYear W20046695412018 @default.
• W2004669541 countsByYear W20046695412019 @default.
• W2004669541 countsByYear W20046695412020 @default.
• W2004669541 countsByYear W20046695412021 @default.
• W2004669541 countsByYear W20046695412022 @default.
• W2004669541 countsByYear W20046695412023 @default.
• W2004669541 crossrefType "journal-article" @default.
• W2004669541 hasAuthorship W2004669541A5009421635 @default.
• W2004669541 hasAuthorship W2004669541A5027802532 @default.
• W2004669541 hasAuthorship W2004669541A5042870776 @default.
• W2004669541 hasAuthorship W2004669541A5062610703 @default.
• W2004669541 hasAuthorship W2004669541A5077005929 @default.
• W2004669541 hasAuthorship W2004669541A5079695722 @default.
• W2004669541 hasConcept C126322002 @default.
• W2004669541 hasConcept C126838900 @default.
• W2004669541 hasConcept C139059822 @default.
• W2004669541 hasConcept C141071460 @default.
• W2004669541 hasConcept C142724271 @default.
• W2004669541 hasConcept C2777546739 @default.
• W2004669541 hasConcept C2777819096 @default.
• W2004669541 hasConcept C2778902805 @default.
• W2004669541 hasConcept C2911218072 @default.
• W2004669541 hasConcept C2989005 @default.
• W2004669541 hasConcept C2994415158 @default.
• W2004669541 hasConcept C529295009 @default.
• W2004669541 hasConcept C71924100 @default.
• W2004669541 hasConcept C76856502 @default.
• W2004669541 hasConceptScore W2004669541C126322002 @default.
• W2004669541 hasConceptScore W2004669541C126838900 @default.
• W2004669541 hasConceptScore W2004669541C139059822 @default.
• W2004669541 hasConceptScore W2004669541C141071460 @default.
• W2004669541 hasConceptScore W2004669541C142724271 @default.
• W2004669541 hasConceptScore W2004669541C2777546739 @default.
• W2004669541 hasConceptScore W2004669541C2777819096 @default.
• W2004669541 hasConceptScore W2004669541C2778902805 @default.
• W2004669541 hasConceptScore W2004669541C2911218072 @default.
• W2004669541 hasConceptScore W2004669541C2989005 @default.
• W2004669541 hasConceptScore W2004669541C2994415158 @default.
• W2004669541 hasConceptScore W2004669541C529295009 @default.
• W2004669541 hasConceptScore W2004669541C71924100 @default.
• W2004669541 hasConceptScore W2004669541C76856502 @default.
• W2004669541 hasIssue "6" @default.
• W2004669541 hasLocation W20046695411 @default.
• W2004669541 hasLocation W20046695412 @default.
• W2004669541 hasOpenAccess W2004669541 @default.
• W2004669541 hasPrimaryLocation W20046695411 @default.
• W2004669541 hasRelatedWork W1970456268 @default.
• W2004669541 hasRelatedWork W2004669541 @default.
• W2004669541 hasRelatedWork W2060252924 @default.
• W2004669541 hasRelatedWork W2170444883 @default.
• W2004669541 hasRelatedWork W2391855898 @default.
• W2004669541 hasRelatedWork W2734513505 @default.
• W2004669541 hasRelatedWork W2913786724 @default.
• W2004669541 hasRelatedWork W2993433726 @default.
• W2004669541 hasRelatedWork W3112107043 @default.
• W2004669541 hasRelatedWork W4324132380 @default.
• W2004669541 hasVolume "60" @default.
• W2004669541 isParatext "false" @default.
• W2004669541 isRetracted "false" @default.
• W2004669541 magId "2004669541" @default.
• W2004669541 workType "article" @default.