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• W2004671175 abstract "The Stereotypic head-down sniffing response to systemically administered apomorphine (0.65 μmol/kg) was assessed in rats 48 h after the bilateral injection of 0.2–0.5 μl of the irreversible receptor antagonistN-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (60 μg/μl) into the caudate-putamen and nucleus accumbens. This response was significantly attenuated in animals that had received injections ofN-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline into the anterior/ventral part of the caudate-putamen but not in those that received injections into regions more dorsal/posterior. Animals were killed after apomorphine challenge and the region of dopamine D1 or D2 receptor reduction due toN-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline mapped and quantified. This analysis revealed that the dopamine receptors involved in the apomorphine-induced stereotyped head-down sniffing response were located in a discrete region of the ventrolateral caudate-putamen and the dorsolateral nucleus accumbens. Animals that were pretreated with the selective dopamine D2 receptor antagonist raclopride (0–20 μmol/kg, i.p.) 20 min prior to central injection ofN-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline into this area showed a dose-dependent protection of the stereotyped sniffing response to systemic apomorphine 48 h later. This combination of techniques constitutes a novel way to investigate striatal function and the results obtained support the concept of a functional subdivision of both the caudate-putamen and the nucleus accumbens." @default.
• W2004671175 created "2016-06-24" @default.
• W2004671175 creator A5014698220 @default.
• W2004671175 creator A5046699521 @default.
• W2004671175 date "1989-01-01" @default.
• W2004671175 modified "2023-09-28" @default.
• W2004671175 title "Localization of striatal dopamine receptor function by central injection of an irreversible receptor antagonist" @default.
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• W2004671175 doi "https://doi.org/10.1016/0306-4522(89)90297-2" @default.
• W2004671175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2601845" @default.
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