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• W2004671192 endingPage "651" @default.
• W2004671192 startingPage "638" @default.
• W2004671192 abstract "The rate and association constants (kinetic constants) which comprise a seven state cross-bridge scheme were deduced by sinusoidal analysis in chemically skinned rabbit psoas muscle fibers at 20 degrees C, 200 mM ionic strength, and during maximal Ca2+ activation (pCa 4.54-4.82). The kinetic constants were then used to calculate the steady state probability of cross-bridges in each state as the function of MgATP, MgADP, and phosphate (Pi) concentrations. This calculation showed that 72% of available cross-bridges were (strongly) attached during our control activation (5 mM MgATP, 8 mM Pi), which agreed approximately with the stiffness ratio (active:rigor, 69 +/- 3%); active stiffness was measured during the control activation, and rigor stiffness after an induction of the rigor state. By assuming that isometric tension is a linear combination of probabilities of cross-bridges in each state, and by measuring tension as the function of MgATP, MgADP, and Pi concentrations, we deduced the force associated with each cross-bridge state. Data from the osmotic compression of muscle fibers by dextran T500 were used to deduce the force associated with one of the cross-bridge states. Our results show that force is highest in the AM*ADP.Pi state (A = actin, M = myosin). Since the state which leads into the AM*ADP.Pi state is the weakly attached AM.ADP.Pi state, we confirm that the force development occurs on Pi isomerization (AM.ADP.Pi --> AM*ADP.Pi). Our results also show that a minimal force change occurs with the release of Pi or MgADP, and that force declines gradually with ADP isomerization (AM*ADP -->AM.ADP), ATP isomerization (AM+ATP-->AM*ATP), and with cross-bridge detachment. Force of the AM state agreed well with force measured after induction of the rigor state, indicating that the AM state is a close approximation of the rigor state. The stiffness results obtained as functions of MgATP, MgADP, and Pi concentrations were generally consistent with the cross-bridge scheme." @default.
• W2004671192 created "2016-06-24" @default.
• W2004671192 creator A5064087943 @default.
• W2004671192 creator A5081146593 @default.
• W2004671192 date "1993-08-01" @default.
• W2004671192 modified "2023-10-18" @default.
• W2004671192 title "Cross-bridge scheme and force per cross-bridge state in skinned rabbit psoas muscle fibers" @default.
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• W2004671192 doi "https://doi.org/10.1016/s0006-3495(93)81109-3" @default.
• W2004671192 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1225766" @default.
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• W2004671192 hasPublicationYear "1993" @default.
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